Acute necrotizing encephalopathy of childhood: a severe case with fatal outcome
Acute necrotizing encephalopathy of childhood (ANEC) is a rare condition which is important for clinicians to recognize as it has a high mortality rate and can result in significant neurological morbidities. It presents as acute encephalopathy with radiological findings of symmetrical brain lesions...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/77949/ http://psasir.upm.edu.my/id/eprint/77949/1/2020042012144646_MJMHS_0455.pdf |
| _version_ | 1848858370893676544 |
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| author | Lee, Yee Lin Abu Hassan, Hasyma Ismail, Intan Hakimah |
| author_facet | Lee, Yee Lin Abu Hassan, Hasyma Ismail, Intan Hakimah |
| author_sort | Lee, Yee Lin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Acute necrotizing encephalopathy of childhood (ANEC) is a rare condition which is important for clinicians to recognize as it has a high mortality rate and can result in significant neurological morbidities. It presents as acute encephalopathy with radiological findings of symmetrical brain lesions in bilateral thalami, putamen, brain stem tegmentum, internal capsule, periventricular white matter and cerebellar medulla. Intravenous methylprednisolone is the mainstay of treatment. Immunoglobulin therapy and therapeutic hypothermia may be used as adjunctive therapy in cases with severe clinical and neuroradiological presentation. We present a case of severe ANEC and discuss the clinical manifestations, neuroimaging and management options. |
| first_indexed | 2025-11-15T12:12:22Z |
| format | Article |
| id | upm-77949 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:12:22Z |
| publishDate | 2020 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-779492020-05-04T17:49:28Z http://psasir.upm.edu.my/id/eprint/77949/ Acute necrotizing encephalopathy of childhood: a severe case with fatal outcome Lee, Yee Lin Abu Hassan, Hasyma Ismail, Intan Hakimah Acute necrotizing encephalopathy of childhood (ANEC) is a rare condition which is important for clinicians to recognize as it has a high mortality rate and can result in significant neurological morbidities. It presents as acute encephalopathy with radiological findings of symmetrical brain lesions in bilateral thalami, putamen, brain stem tegmentum, internal capsule, periventricular white matter and cerebellar medulla. Intravenous methylprednisolone is the mainstay of treatment. Immunoglobulin therapy and therapeutic hypothermia may be used as adjunctive therapy in cases with severe clinical and neuroradiological presentation. We present a case of severe ANEC and discuss the clinical manifestations, neuroimaging and management options. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/77949/1/2020042012144646_MJMHS_0455.pdf Lee, Yee Lin and Abu Hassan, Hasyma and Ismail, Intan Hakimah (2020) Acute necrotizing encephalopathy of childhood: a severe case with fatal outcome. Malaysian Journal of Medicine and Health Sciences, 16 (2). pp. 323-325. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2020042012144646_MJMHS_0455.pdf |
| spellingShingle | Lee, Yee Lin Abu Hassan, Hasyma Ismail, Intan Hakimah Acute necrotizing encephalopathy of childhood: a severe case with fatal outcome |
| title | Acute necrotizing encephalopathy of childhood: a severe case with fatal outcome |
| title_full | Acute necrotizing encephalopathy of childhood: a severe case with fatal outcome |
| title_fullStr | Acute necrotizing encephalopathy of childhood: a severe case with fatal outcome |
| title_full_unstemmed | Acute necrotizing encephalopathy of childhood: a severe case with fatal outcome |
| title_short | Acute necrotizing encephalopathy of childhood: a severe case with fatal outcome |
| title_sort | acute necrotizing encephalopathy of childhood: a severe case with fatal outcome |
| url | http://psasir.upm.edu.my/id/eprint/77949/ http://psasir.upm.edu.my/id/eprint/77949/ http://psasir.upm.edu.my/id/eprint/77949/1/2020042012144646_MJMHS_0455.pdf |