Misleading free thyroxine (FT4): a case report
Interpretation of thyroid function test (TFT) is often straightforward but in certain scenarios, discordance between the clinical impression and the laboratory results exists. A 50-year-old woman with a ten years history of hypothyroidism on levothyroxine presented with a recent notable change in TF...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/77948/ http://psasir.upm.edu.my/id/eprint/77948/1/2020042012133045_MJMHS_0331.pdf |
| _version_ | 1848858370626289664 |
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| author | Hashim, Nurul Hidayah Samsudin, Intan Nureslyna Masiman, Ana Daliela Chellappah Thambiah, Subashini |
| author_facet | Hashim, Nurul Hidayah Samsudin, Intan Nureslyna Masiman, Ana Daliela Chellappah Thambiah, Subashini |
| author_sort | Hashim, Nurul Hidayah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Interpretation of thyroid function test (TFT) is often straightforward but in certain scenarios, discordance between the clinical impression and the laboratory results exists. A 50-year-old woman with a ten years history of hypothyroidism on levothyroxine presented with a recent notable change in TFT [elevated free thyroxine (FT4) and thyroid-stimulating hormone (TSH)], in an otherwise clinically euthyroid and previously stable TFT, leading to levothyroxine being withheld. This case report highlights the possibility of assay interference as a cause of discordant TFT. It also draws the importance of close collaboration between clinicians and the laboratory to avoid unnecessary investigations and inappropriate management of such a case. |
| first_indexed | 2025-11-15T12:12:22Z |
| format | Article |
| id | upm-77948 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:12:22Z |
| publishDate | 2020 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-779482020-05-04T17:49:24Z http://psasir.upm.edu.my/id/eprint/77948/ Misleading free thyroxine (FT4): a case report Hashim, Nurul Hidayah Samsudin, Intan Nureslyna Masiman, Ana Daliela Chellappah Thambiah, Subashini Interpretation of thyroid function test (TFT) is often straightforward but in certain scenarios, discordance between the clinical impression and the laboratory results exists. A 50-year-old woman with a ten years history of hypothyroidism on levothyroxine presented with a recent notable change in TFT [elevated free thyroxine (FT4) and thyroid-stimulating hormone (TSH)], in an otherwise clinically euthyroid and previously stable TFT, leading to levothyroxine being withheld. This case report highlights the possibility of assay interference as a cause of discordant TFT. It also draws the importance of close collaboration between clinicians and the laboratory to avoid unnecessary investigations and inappropriate management of such a case. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/77948/1/2020042012133045_MJMHS_0331.pdf Hashim, Nurul Hidayah and Samsudin, Intan Nureslyna and Masiman, Ana Daliela and Chellappah Thambiah, Subashini (2020) Misleading free thyroxine (FT4): a case report. Malaysian Journal of Medicine and Health Sciences, 16 (2). pp. 320-322. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2020042012133045_MJMHS_0331.pdf |
| spellingShingle | Hashim, Nurul Hidayah Samsudin, Intan Nureslyna Masiman, Ana Daliela Chellappah Thambiah, Subashini Misleading free thyroxine (FT4): a case report |
| title | Misleading free thyroxine (FT4): a case report |
| title_full | Misleading free thyroxine (FT4): a case report |
| title_fullStr | Misleading free thyroxine (FT4): a case report |
| title_full_unstemmed | Misleading free thyroxine (FT4): a case report |
| title_short | Misleading free thyroxine (FT4): a case report |
| title_sort | misleading free thyroxine (ft4): a case report |
| url | http://psasir.upm.edu.my/id/eprint/77948/ http://psasir.upm.edu.my/id/eprint/77948/ http://psasir.upm.edu.my/id/eprint/77948/1/2020042012133045_MJMHS_0331.pdf |