Antinociceptive activity of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol in mice
A novel compound from diarylpentanoids analogues, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol, was evaluated on its antinociceptive activity in mice through acetic acid-induced abdominal constriction test. Antinociception of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol was...
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| Format: | Conference or Workshop Item |
| Language: | English |
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Department of Biology, Faculty of Science, Universiti Putra Malaysia
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/77586/ http://psasir.upm.edu.my/id/eprint/77586/1/i-SIMBIOMAS%202016%20100.pdf |
| _version_ | 1848858289468604416 |
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| author | Ong, Hui Ming Ahmad Azmi, Ahmad Farhan Leong, Sze Wei Abas, Faridah Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan |
| author_facet | Ong, Hui Ming Ahmad Azmi, Ahmad Farhan Leong, Sze Wei Abas, Faridah Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan |
| author_sort | Ong, Hui Ming |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | A novel compound from diarylpentanoids analogues, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol, was evaluated on its antinociceptive activity in mice through acetic acid-induced abdominal constriction test. Antinociception of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol was indicated by the reduction in the mean of the number of abdominal constrictions in the test groups compared to the control group. Acetylsalicylic acid (ASA, 100 mg/kg) was used as reference drugs while control group only received vehicle (5% DMSO: 5% Tween 20: 90% Distilled water) that used to dissolve the compound. The mice that received intraperitoneal injections of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol at 0.1, 0.3, 1.0 and 3.0 mg/kg showed 48.34%, 60.79%, 90.07% and 98.54% of inhibition respectively. Acetic acid injection in mice peritoneal cavity can promote the release of many inflammatory mediators such as prostaglandin, bradykinin, substance P, TNF-α, IL-1β, IL-8 and other mediator, which will then stimulate primary afferent neurons to enhance the release of aspartate and glutamate. Hence, the result obtained from this chemical model of nociception suggests that the antinociceptive activity of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol may be linked partly to the inhibition of the inflammatory mediators. |
| first_indexed | 2025-11-15T12:11:05Z |
| format | Conference or Workshop Item |
| id | upm-77586 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:11:05Z |
| publishDate | 2016 |
| publisher | Department of Biology, Faculty of Science, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-775862020-04-15T16:34:10Z http://psasir.upm.edu.my/id/eprint/77586/ Antinociceptive activity of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol in mice Ong, Hui Ming Ahmad Azmi, Ahmad Farhan Leong, Sze Wei Abas, Faridah Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan A novel compound from diarylpentanoids analogues, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol, was evaluated on its antinociceptive activity in mice through acetic acid-induced abdominal constriction test. Antinociception of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol was indicated by the reduction in the mean of the number of abdominal constrictions in the test groups compared to the control group. Acetylsalicylic acid (ASA, 100 mg/kg) was used as reference drugs while control group only received vehicle (5% DMSO: 5% Tween 20: 90% Distilled water) that used to dissolve the compound. The mice that received intraperitoneal injections of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol at 0.1, 0.3, 1.0 and 3.0 mg/kg showed 48.34%, 60.79%, 90.07% and 98.54% of inhibition respectively. Acetic acid injection in mice peritoneal cavity can promote the release of many inflammatory mediators such as prostaglandin, bradykinin, substance P, TNF-α, IL-1β, IL-8 and other mediator, which will then stimulate primary afferent neurons to enhance the release of aspartate and glutamate. Hence, the result obtained from this chemical model of nociception suggests that the antinociceptive activity of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol may be linked partly to the inhibition of the inflammatory mediators. Department of Biology, Faculty of Science, Universiti Putra Malaysia 2016 Conference or Workshop Item PeerReviewed text en http://psasir.upm.edu.my/id/eprint/77586/1/i-SIMBIOMAS%202016%20100.pdf Ong, Hui Ming and Ahmad Azmi, Ahmad Farhan and Leong, Sze Wei and Abas, Faridah and Israf Ali, Daud Ahmad and Sulaiman, Mohd Roslan (2016) Antinociceptive activity of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol in mice. In: Malaysia International Biology Symposium 2016, 26-27 Oct. 2016, PICC, Putrajaya, Malaysia. (p. 100). |
| spellingShingle | Ong, Hui Ming Ahmad Azmi, Ahmad Farhan Leong, Sze Wei Abas, Faridah Israf Ali, Daud Ahmad Sulaiman, Mohd Roslan Antinociceptive activity of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol in mice |
| title | Antinociceptive activity of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol in mice |
| title_full | Antinociceptive activity of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol in mice |
| title_fullStr | Antinociceptive activity of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol in mice |
| title_full_unstemmed | Antinociceptive activity of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol in mice |
| title_short | Antinociceptive activity of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol in mice |
| title_sort | antinociceptive activity of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol in mice |
| url | http://psasir.upm.edu.my/id/eprint/77586/ http://psasir.upm.edu.my/id/eprint/77586/1/i-SIMBIOMAS%202016%20100.pdf |