Dipeptidyl peptidase IV (DPP IV) inhibitory activity screening of Momordica charantia, Taraxacum officinale and Trigonella foenum-graecumextracts in vitro
Diabetes, a globally popular disease which attracted the attention of many researches worldwide to discover a non-toxic and side effect free remedy for this disease. Inhibition of DPP IV enzymes has been adopted as one of the strategies in recent years in controlling diabetes. DPP IV inhibitor inhib...
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| Format: | Conference or Workshop Item |
| Language: | English |
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Department of Biology, Faculty of Science, Universiti Putra Malaysia
2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/77582/ http://psasir.upm.edu.my/id/eprint/77582/1/i-SIMBIOMAS%202016%2095.pdf |
| _version_ | 1848858288389619712 |
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| author | Perumal, N. Nallappan, Meenakshii Mohd Kama, N. Zukefli, S. N. Shaharudin, M. F. I. Tee, T. T. Cheah, Y. H. |
| author_facet | Perumal, N. Nallappan, Meenakshii Mohd Kama, N. Zukefli, S. N. Shaharudin, M. F. I. Tee, T. T. Cheah, Y. H. |
| author_sort | Perumal, N. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Diabetes, a globally popular disease which attracted the attention of many researches worldwide to discover a non-toxic and side effect free remedy for this disease. Inhibition of DPP IV enzymes has been adopted as one of the strategies in recent years in controlling diabetes. DPP IV inhibitor inhibits the dipeptidyl peptidase enzyme which degrades several incretin hormones that are vital in the production of insulin and managing the blood glucose level.Thus, the present study was designed to investigate the DPP IV inhibitory effects of plants having antidiabetic property. In vitro DPP IV inhibition was evaluated by the specific inhibitory activity of Momordica charantia (whole fruit), Taraxacum officinale (whole plant) and Trigonella foenum-graecum (seed) extracts prepared with heat treatment using petroleum ether, acetone, ethanol and water as solvents. Among the tested plants T. officinale and M. charantia acetone extracts exhibited strong DPP IV activity inhibition, with 78.88% and 54.13% respectively. The present study is the first report on screening of DPP IV inhibitory activity of T. officinale, M. charantiaand T. foenum-graecum extracts. This could provide a new insight into DPP IV inhibitors from plants that could be useful for treatment of type 2 diabetes. |
| first_indexed | 2025-11-15T12:11:04Z |
| format | Conference or Workshop Item |
| id | upm-77582 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:11:04Z |
| publishDate | 2016 |
| publisher | Department of Biology, Faculty of Science, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-775822020-04-15T16:34:38Z http://psasir.upm.edu.my/id/eprint/77582/ Dipeptidyl peptidase IV (DPP IV) inhibitory activity screening of Momordica charantia, Taraxacum officinale and Trigonella foenum-graecumextracts in vitro Perumal, N. Nallappan, Meenakshii Mohd Kama, N. Zukefli, S. N. Shaharudin, M. F. I. Tee, T. T. Cheah, Y. H. Diabetes, a globally popular disease which attracted the attention of many researches worldwide to discover a non-toxic and side effect free remedy for this disease. Inhibition of DPP IV enzymes has been adopted as one of the strategies in recent years in controlling diabetes. DPP IV inhibitor inhibits the dipeptidyl peptidase enzyme which degrades several incretin hormones that are vital in the production of insulin and managing the blood glucose level.Thus, the present study was designed to investigate the DPP IV inhibitory effects of plants having antidiabetic property. In vitro DPP IV inhibition was evaluated by the specific inhibitory activity of Momordica charantia (whole fruit), Taraxacum officinale (whole plant) and Trigonella foenum-graecum (seed) extracts prepared with heat treatment using petroleum ether, acetone, ethanol and water as solvents. Among the tested plants T. officinale and M. charantia acetone extracts exhibited strong DPP IV activity inhibition, with 78.88% and 54.13% respectively. The present study is the first report on screening of DPP IV inhibitory activity of T. officinale, M. charantiaand T. foenum-graecum extracts. This could provide a new insight into DPP IV inhibitors from plants that could be useful for treatment of type 2 diabetes. Department of Biology, Faculty of Science, Universiti Putra Malaysia 2016 Conference or Workshop Item PeerReviewed text en http://psasir.upm.edu.my/id/eprint/77582/1/i-SIMBIOMAS%202016%2095.pdf Perumal, N. and Nallappan, Meenakshii and Mohd Kama, N. and Zukefli, S. N. and Shaharudin, M. F. I. and Tee, T. T. and Cheah, Y. H. (2016) Dipeptidyl peptidase IV (DPP IV) inhibitory activity screening of Momordica charantia, Taraxacum officinale and Trigonella foenum-graecumextracts in vitro. In: Malaysia International Biology Symposium 2016, 26-27 Oct. 2016, PICC, Putrajaya, Malaysia. (p. 95). |
| spellingShingle | Perumal, N. Nallappan, Meenakshii Mohd Kama, N. Zukefli, S. N. Shaharudin, M. F. I. Tee, T. T. Cheah, Y. H. Dipeptidyl peptidase IV (DPP IV) inhibitory activity screening of Momordica charantia, Taraxacum officinale and Trigonella foenum-graecumextracts in vitro |
| title | Dipeptidyl peptidase IV (DPP IV) inhibitory activity screening of Momordica charantia, Taraxacum officinale and Trigonella foenum-graecumextracts in vitro |
| title_full | Dipeptidyl peptidase IV (DPP IV) inhibitory activity screening of Momordica charantia, Taraxacum officinale and Trigonella foenum-graecumextracts in vitro |
| title_fullStr | Dipeptidyl peptidase IV (DPP IV) inhibitory activity screening of Momordica charantia, Taraxacum officinale and Trigonella foenum-graecumextracts in vitro |
| title_full_unstemmed | Dipeptidyl peptidase IV (DPP IV) inhibitory activity screening of Momordica charantia, Taraxacum officinale and Trigonella foenum-graecumextracts in vitro |
| title_short | Dipeptidyl peptidase IV (DPP IV) inhibitory activity screening of Momordica charantia, Taraxacum officinale and Trigonella foenum-graecumextracts in vitro |
| title_sort | dipeptidyl peptidase iv (dpp iv) inhibitory activity screening of momordica charantia, taraxacum officinale and trigonella foenum-graecumextracts in vitro |
| url | http://psasir.upm.edu.my/id/eprint/77582/ http://psasir.upm.edu.my/id/eprint/77582/1/i-SIMBIOMAS%202016%2095.pdf |