Ts1Cje mouse model for Down syndrome exhibits motor function deficit; the potential role of MRFS and peripheral nervous system

QR Code

Ts1Cje mouse model for Down syndrome exhibits motor function deficit; the potential role of MRFS and peripheral nervous system

Introduction: Down syndrome (DS) is a chromosomal abnormality caused by presence of extra-copy of human chromosome 21. Motor dysfunction due to hypotonia is commonly seen in DS individuals and its etiology is still unknown. In this study, we employed the Ts1Cje, a mouse model for DS to investigate t...

Full description

Bibliographic Details
Main Authors:	Bala, Usman, Othman, Fauziah, Lai, Mei I., Ling, King Hwa, Cheah, Pike See
Format:	Conference or Workshop Item
Language:	English
Published:	2015
Online Access:	http://psasir.upm.edu.my/id/eprint/75605/ http://psasir.upm.edu.my/id/eprint/75605/1/Ts1Cje%20mouse%20model%20for%20Down%20syndrome%20exhibits%20motor%20function%20deficit%3B%20the%20potential%20role%20of%20MRFS%20and%20peripheral%20nervous%20system.pdf

Similar Items

Expression profiling of genes involved in the development and function of skeletal muscles in Ts1Cje mouse model of down syndrome
by: Cheah, Pike See, et al.
Published: (2018)

Ts1Cje mouse model for Down syndrome research
by: Ling, King Hwa
Published: (2015)

Targeted differential gene expression profiling of skeletal muscles isolated from Ts1Cje mouse model for Down syndrome
by: Leong, Melody Pui Yee, et al.
Published: (2015)

The role of JAK-STAT signalling in the developing brain of Ts1Cje mouse model for Down syndrome
by: Lee, Han Chung, et al.
Published: (2015)

Histological and molecular characterisation of hypotonia in adult Ts1Cje mouse model for down syndrome
by: Bala, Usman
Published: (2016)

Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome
by: Tan, Kai Leng, et al.
Published: (2014)

Perturbed metabolic profiles associated with muscle weakness seen in adult Ts1Cje mouse model of Down syndrome
by: Lim, Chai Ling, et al.
Published: (2019)

The expression profile of miR-3099 during neural development of Ts1Cje mouse model of down syndrome
by: Zainal Abidin, Shahidee, et al.
Published: (2021)

Overexpression of interferon alpha or beta receptors in the brain of adult Ts1Cje mouse model of Down syndrome
by: Tan, Kai Leng, et al.
Published: (2015)

Disrupted interferon-related molecular networks and the over-expressed Ifnar1 in the brain of adult Ts1Cje mouse model of Down syndrome
by: Tan, Kai Leng, et al.
Published: (2016)

Defects in nerve conduction velocity and different muscle fibre-type specificity contribute to muscle weakness in Ts1Cje Down syndrome mouse model
by: Bala, Usman, et al.
Published: (2018)

Expression profiling of notch signalling pathway and gamma-secretase activity in the brain of Ts1Cje mouse model of down syndrome
by: Md Yusof, Hadri Hadi, et al.
Published: (2019)

Gene network disruptions and neurogenesis defects in the adult Ts1Cje mouse model of Down syndrome
by: Hewitt, Chelsee Ann, et al.
Published: (2010)

Gene and protein expression profiles of JAK-STAT signalling pathway in the developing brain of the Ts1Cje down syndrome mouse model
by: Lee, Han Chung, et al.
Published: (2019)

Reduced REST expression in neural progenitor cells, adult cortex, and impaired REST nuclear translocation in the prefrontal cortex of Ts1Cje mouse model of Down Syndrome
by: Chong, Teik Lim, et al.
Published: (2024)

The identification of disrupted molecular networks involved in brain maturation and function in the Ts1Cje mouse model of down syndrome.
by: Cheah, P. S.

Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks
by: Ling, King Hwa, et al.
Published: (2014)

Expression of gamma secretase and notch signalling pathway in TS1CJE mouse model of down syndrome
by: Md Yusof, Hadri Hadi
Published: (2017)

Transcriptomic and protein expression analyses of skeletal muscles isolated from Ts1cje mouse model for Down syndrome
by: Leong, Melody Pui Yee
Published: (2017)

Identification of disrupted molecular networks involved in brain maturation and function in the TS1CJE mouse model of down syndrome
by: Tan, Kai Leng
Published: (2016)

Metabolic profiling of neurospheres derived from embryonic cerebral cortex Ts1Cje mouse model for down syndrome
by: Mohamed Seth, Eryse Amira
Published: (2019)

Metabolic and functional characterisation of adult skeletal muscle in down syndrome mouse model (Ts1CJe) for insights into hypotonia in human condition
by: Lim, Chai Ling
Published: (2017)

Chromosomal and cellular therapeutic approaches for Down syndrome: a research update
by: Huang, Tan, et al.
Published: (2024)

The restoration of REST inhibits reactivity of Down syndrome iPSC-derived astrocytes
by: Huang, Tan, et al.
Published: (2025)

Mitochondrial dysfunction in Down Syndrome: from pathology to therapy
by: Tan, Kai-Leng, et al.
Published: (2023)

Dysregulation of REST and its target genes impacts the fate of neural progenitor cells in down syndrome
by: Tan, Huang, et al.
Published: (2025)

Brain insulin resistance in down syndrome: involvement of PI3K-AKT/MTOR axis in early-onset of Alzheimer's disease and its potential as a therapeutic target
by: Azimzadeh, Mansour, et al.
Published: (2024)

REST targets JAK–STAT and HIF-1 signaling pathways in human Down syndrome brain and neural cells
by: Huang, Tan, et al.
Published: (2023)

Lithium restores nuclear REST and Mitigates oxidative stress in down syndrome iPSC-Derived neurons
by: Lam, Xin-Jieh, et al.
Published: (2025)

Potential role of JAK-STAT signaling pathway in the neurogenic-to-gliogenic shift in down syndrome brain
by: Lee, Han Chung, et al.
Published: (2016)

Modelling changes in excitability of the peripheral nervous system using compartmentalised microfluidic culture
by: Rockliffe, Alice
Published: (2021)

Spatiotemporal expression and molecular characterization of miR-344b and miR-344c in the developing mouse brain
by: Leong, Jia Wen, et al.
Published: (2016)

Spatiotemporal expression profiling and molecular characterisation of miR-344b and miR-344c in the developing mouse brain
by: Leong, Jia Wen, et al.
Published: (2015)

Harvesting the maximum length of sciatic nerve from adult mice: a step-by-step approach
by: Bala, Usman, et al.
Published: (2014)

SOX3 expression in the glial system of the developing and adult mouse cerebellum
by: Cheah, Pike‑See, et al.
Published: (2015)

MicroRNAs and intellectual disability (ID) in Down syndrome, X-linked ID and Fragile X syndrome
by: Siew, Wei Hong, et al.
Published: (2013)

Understanding perspectives and research trends in down syndrome neuropathogenesis: a bibliometric analysis
by: Huang, Tan, et al.
Published: (2024)

In silico prediction and validation of Gfap as miR-3099 target in the mouse brain
by: Zainal Abidin, Shahidee, et al.
Published: (2017)

The master hat
by: Cheah, Pike See, et al.
Published: (2016)

Construction and validation of a mammalian expression vector for in utero electroporation study of miR-3099 in the mouse neocortex
by: Zainal Abidin, Shahidee, et al.
Published: (2018)