The role of JAK-STAT signalling in the developing brain of Ts1Cje mouse model for Down syndrome
Introduction: The JAK-STAT signalling pathway is essential for proper regulation of the gliogenesis process during brain development. Both Down syndrome (DS) individuals and DS mouse model showed reduced number of neuron but increase number of astrocyte in the brain; suggesting that dysregulation of...
| Main Authors: | Lee, Han Chung, Nordin, Norshariza, Vidyadaran, Sharmili, Cheah, Pike See, Ling, King Hwa |
|---|---|
| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2015
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/75599/ http://psasir.upm.edu.my/id/eprint/75599/1/The%20role%20of%20JAK-STAT%20signalling%20in%20the%20developing%20brain%20of%20Ts1Cje%20mouse%20model%20for%20Down%20syndrome.pdf |
Similar Items
Gene and protein expression profiles of JAK-STAT signalling pathway in the developing brain of the Ts1Cje down syndrome mouse model
by: Lee, Han Chung, et al.
Published: (2019)
by: Lee, Han Chung, et al.
Published: (2019)
Overexpression of interferon alpha or beta receptors in the brain of adult Ts1Cje mouse model of Down syndrome
by: Tan, Kai Leng, et al.
Published: (2015)
by: Tan, Kai Leng, et al.
Published: (2015)
Ts1Cje mouse model for Down syndrome research
by: Ling, King Hwa
Published: (2015)
by: Ling, King Hwa
Published: (2015)
Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome
by: Tan, Kai Leng, et al.
Published: (2014)
by: Tan, Kai Leng, et al.
Published: (2014)
Disrupted interferon-related molecular networks and the over-expressed Ifnar1 in the brain of adult Ts1Cje mouse model of Down syndrome
by: Tan, Kai Leng, et al.
Published: (2016)
by: Tan, Kai Leng, et al.
Published: (2016)
Potential role of JAK-STAT signaling pathway in the neurogenic-to-gliogenic shift in down syndrome brain
by: Lee, Han Chung, et al.
Published: (2016)
by: Lee, Han Chung, et al.
Published: (2016)
The expression profile of miR-3099 during neural development of Ts1Cje mouse model of down syndrome
by: Zainal Abidin, Shahidee, et al.
Published: (2021)
by: Zainal Abidin, Shahidee, et al.
Published: (2021)
Expression profiling of genes involved in the development and function of skeletal muscles in Ts1Cje mouse model of down syndrome
by: Cheah, Pike See, et al.
Published: (2018)
by: Cheah, Pike See, et al.
Published: (2018)
REST targets JAK–STAT and HIF-1 signaling pathways in human Down syndrome brain and neural cells
by: Huang, Tan, et al.
Published: (2023)
by: Huang, Tan, et al.
Published: (2023)
Expression profiling of notch signalling pathway and gamma-secretase activity in the brain of Ts1Cje mouse model of down syndrome
by: Md Yusof, Hadri Hadi, et al.
Published: (2019)
by: Md Yusof, Hadri Hadi, et al.
Published: (2019)
Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks
by: Ling, King Hwa, et al.
Published: (2014)
by: Ling, King Hwa, et al.
Published: (2014)
Targeted differential gene expression profiling of skeletal muscles isolated from Ts1Cje mouse model for Down syndrome
by: Leong, Melody Pui Yee, et al.
Published: (2015)
by: Leong, Melody Pui Yee, et al.
Published: (2015)
Ts1Cje mouse model for Down syndrome exhibits motor function deficit; the potential role of MRFS and peripheral nervous system
by: Bala, Usman, et al.
Published: (2015)
by: Bala, Usman, et al.
Published: (2015)
The identification of disrupted molecular networks involved in brain maturation and function in the Ts1Cje mouse model of down syndrome.
by: Cheah, P. S.
by: Cheah, P. S.
Perturbed metabolic profiles associated with muscle weakness seen in adult Ts1Cje mouse model of Down syndrome
by: Lim, Chai Ling, et al.
Published: (2019)
by: Lim, Chai Ling, et al.
Published: (2019)
Gene network disruptions and neurogenesis defects in the adult Ts1Cje mouse model of Down syndrome
by: Hewitt, Chelsee Ann, et al.
Published: (2010)
by: Hewitt, Chelsee Ann, et al.
Published: (2010)
Identification of disrupted molecular networks involved in brain maturation and function in the TS1CJE mouse model of down syndrome
by: Tan, Kai Leng
Published: (2016)
by: Tan, Kai Leng
Published: (2016)
Histological and molecular characterisation of hypotonia in adult Ts1Cje mouse model for down syndrome
by: Bala, Usman
Published: (2016)
by: Bala, Usman
Published: (2016)
Reduced REST expression in neural progenitor cells, adult cortex, and impaired REST nuclear translocation in the prefrontal cortex of Ts1Cje mouse model of Down Syndrome
by: Chong, Teik Lim, et al.
Published: (2024)
by: Chong, Teik Lim, et al.
Published: (2024)
Expression of gamma secretase and notch signalling pathway in TS1CJE mouse model of down syndrome
by: Md Yusof, Hadri Hadi
Published: (2017)
by: Md Yusof, Hadri Hadi
Published: (2017)
Defects in nerve conduction velocity and different muscle fibre-type specificity contribute to muscle weakness in Ts1Cje Down syndrome mouse model
by: Bala, Usman, et al.
Published: (2018)
by: Bala, Usman, et al.
Published: (2018)
Transcriptomic and protein expression analyses of skeletal muscles isolated from Ts1cje mouse model for Down syndrome
by: Leong, Melody Pui Yee
Published: (2017)
by: Leong, Melody Pui Yee
Published: (2017)
Metabolic profiling of neurospheres derived from embryonic cerebral cortex Ts1Cje mouse model for down syndrome
by: Mohamed Seth, Eryse Amira
Published: (2019)
by: Mohamed Seth, Eryse Amira
Published: (2019)
Metabolic and functional characterisation of adult skeletal muscle in down syndrome mouse model (Ts1CJe) for insights into hypotonia in human condition
by: Lim, Chai Ling
Published: (2017)
by: Lim, Chai Ling
Published: (2017)
Mitochondrial dysfunction in Down Syndrome: from pathology to therapy
by: Tan, Kai-Leng, et al.
Published: (2023)
by: Tan, Kai-Leng, et al.
Published: (2023)
Brain insulin resistance in down syndrome: involvement of PI3K-AKT/MTOR axis in early-onset of Alzheimer's disease and its potential as a therapeutic target
by: Azimzadeh, Mansour, et al.
Published: (2024)
by: Azimzadeh, Mansour, et al.
Published: (2024)
Chromosomal and cellular therapeutic approaches for Down syndrome: a research update
by: Huang, Tan, et al.
Published: (2024)
by: Huang, Tan, et al.
Published: (2024)
The restoration of REST inhibits reactivity of Down syndrome iPSC-derived astrocytes
by: Huang, Tan, et al.
Published: (2025)
by: Huang, Tan, et al.
Published: (2025)
Dysregulation of REST and its target genes impacts the fate of neural progenitor cells in down syndrome
by: Tan, Huang, et al.
Published: (2025)
by: Tan, Huang, et al.
Published: (2025)
In silico prediction and validation of Gfap as miR-3099 target in the mouse brain
by: Zainal Abidin, Shahidee, et al.
Published: (2017)
by: Zainal Abidin, Shahidee, et al.
Published: (2017)
Polyphenols mitigating inflammatory mechanisms in Inflammatory Bowel Disease (IBD): focus on NF-κB and JAK/STAT pathways
by: Ismail, Elysha Nur, et al.
Published: (2024)
by: Ismail, Elysha Nur, et al.
Published: (2024)
MicroRNAs and intellectual disability (ID) in Down syndrome, X-linked ID and Fragile X syndrome
by: Siew, Wei Hong, et al.
Published: (2013)
by: Siew, Wei Hong, et al.
Published: (2013)
Lithium restores nuclear REST and Mitigates oxidative stress in down syndrome iPSC-Derived neurons
by: Lam, Xin-Jieh, et al.
Published: (2025)
by: Lam, Xin-Jieh, et al.
Published: (2025)
Spatiotemporal expression and molecular characterization of miR-344b and miR-344c in the developing mouse brain
by: Leong, Jia Wen, et al.
Published: (2016)
by: Leong, Jia Wen, et al.
Published: (2016)
Alzheimer's brain changes
by: Cheah, Pike See, et al.
Published: (2016)
by: Cheah, Pike See, et al.
Published: (2016)
Spatiotemporal expression profiling and molecular characterisation of miR-344b and miR-344c in the developing mouse brain
by: Leong, Jia Wen, et al.
Published: (2015)
by: Leong, Jia Wen, et al.
Published: (2015)
Understanding perspectives and research trends in down syndrome neuropathogenesis: a bibliometric analysis
by: Huang, Tan, et al.
Published: (2024)
by: Huang, Tan, et al.
Published: (2024)
Gene aberrations and methylation analysis of JAK/stat and toll-like receptor downstream signalling in BCR-ABL-negative myeloproliferative neoplasms and myelodysplastic syndrome/myeloproliferative neoplasms overlap syndromes
by: Cai, Chia Yuh
Published: (2021)
by: Cai, Chia Yuh
Published: (2021)
Transient prenatal ruxolitinib treatment promotes neurogenesis and suppresses astrogliogenesis during embryonic mouse brain development
by: Abdullah, Amirah Nabilah, et al.
Published: (2025)
by: Abdullah, Amirah Nabilah, et al.
Published: (2025)
Acquired radioresistance in EMT6 mouse mammary carcinoma cell line is mediated by CTLA-4 and PD-1 throughJAK/STAT/PI3K pathway
by: Ronny Sham, Nur Fatihah, et al.
Published: (2023)
by: Ronny Sham, Nur Fatihah, et al.
Published: (2023)
Similar Items
-
Gene and protein expression profiles of JAK-STAT signalling pathway in the developing brain of the Ts1Cje down syndrome mouse model
by: Lee, Han Chung, et al.
Published: (2019) -
Overexpression of interferon alpha or beta receptors in the brain of adult Ts1Cje mouse model of Down syndrome
by: Tan, Kai Leng, et al.
Published: (2015) -
Ts1Cje mouse model for Down syndrome research
by: Ling, King Hwa
Published: (2015) -
Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome
by: Tan, Kai Leng, et al.
Published: (2014) -
Disrupted interferon-related molecular networks and the over-expressed Ifnar1 in the brain of adult Ts1Cje mouse model of Down syndrome
by: Tan, Kai Leng, et al.
Published: (2016)