Effects of oral fatty acid on left ventricular 2-[18F] Fluoro-2-Deoxy-D-Glucose uptake during whole body positron emission and computed tomography
Background: There are two main myocardial metabolic pathways including glucose oxidative pathway and free fatty acid (FFA) oxidative pathway. FFA is the major source of energy for the heart, generating 60% to 90% of energy while glucose metabolism produces the rest 10% to 40% of energy depending on...
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| Format: | Thesis |
| Language: | English |
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2016
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| Online Access: | http://psasir.upm.edu.my/id/eprint/75323/ http://psasir.upm.edu.my/id/eprint/75323/1/FPSK%28M%29%202016%2040.pdf |
| _version_ | 1848857656982241280 |
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| author | Che Nordin, Mohd Nazmi |
| author_facet | Che Nordin, Mohd Nazmi |
| author_sort | Che Nordin, Mohd Nazmi |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: There are two main myocardial metabolic pathways including glucose oxidative pathway and free fatty acid (FFA) oxidative pathway. FFA is the major source of energy for the heart, generating 60% to 90% of energy while glucose metabolism produces the rest 10% to 40% of energy depending on physiological conditions. Objective: This study was carried out to observe the intensity and to analyze the differences in the intensity of 18F-FDG uptake in the wall of LV WITH and WITHOUT oral ingestion of edible oils during whole body (WB) 18F-FDG PET/CT study. Methodology: This is a prospective study involving patients undergoing modified WB 18F-FDG PET/CT protocol; [Group A (n=12) : WB + oral ingestion of 50ml virgin coconut oil (VCO); Group B (n=9) : WB + oral ingestion of 50ml olive oil(OO)]. And Group C (n=9) applied standard preparation protocol for WB 18F-FDG PET/CT examination. The 18FFDG uptake in the wall of LV was qualitatively and quantitatively assessed. Results: The mean age for group A, B, and C were 49.25 ± 13.19, 56.11 ± 11.66 and 64.33 ± 7.50. The mean BMI were 22.46 ± 3.83, 25.68 ± 5.66 and 26.74 ± 4.26 respectively, while the mean FBS were 5.80 ± 1.23, 5.60 ± 1.61 and 5.73 ± 0.51 respectively. The LV uptake of 18F-FDG was significantly higher in Group C patients. There was a significant difference in mean SUVmax at mid (2.58 ± 3.97 vs 2.28 ± 2.75 vs 6.59 ± 2.09, p=0.002), basal (6.43 ± 8.57 vs 4.87 ± 3.08 vs 13.89 ± 3.77, p=0.005) and apical (6.37 ± 8.27 vs 5.33 ± 3.22 vs 11.42 ± 4.66, p=0.002) of LV. The mean normalized 18F-FDG distribution in 20-segment polar map expressed in percentage for Group B was lower in comparison to Group A and Group C (66.37% vs 63.13% vs 68.78%, p=0.04). Conclusion: Oral ingestion of edible oils leads to preference towards fatty metabolism of myocardium hence reduction in glucose uptake. |
| first_indexed | 2025-11-15T12:01:02Z |
| format | Thesis |
| id | upm-75323 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:01:02Z |
| publishDate | 2016 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-753232025-06-10T02:11:35Z http://psasir.upm.edu.my/id/eprint/75323/ Effects of oral fatty acid on left ventricular 2-[18F] Fluoro-2-Deoxy-D-Glucose uptake during whole body positron emission and computed tomography Che Nordin, Mohd Nazmi Background: There are two main myocardial metabolic pathways including glucose oxidative pathway and free fatty acid (FFA) oxidative pathway. FFA is the major source of energy for the heart, generating 60% to 90% of energy while glucose metabolism produces the rest 10% to 40% of energy depending on physiological conditions. Objective: This study was carried out to observe the intensity and to analyze the differences in the intensity of 18F-FDG uptake in the wall of LV WITH and WITHOUT oral ingestion of edible oils during whole body (WB) 18F-FDG PET/CT study. Methodology: This is a prospective study involving patients undergoing modified WB 18F-FDG PET/CT protocol; [Group A (n=12) : WB + oral ingestion of 50ml virgin coconut oil (VCO); Group B (n=9) : WB + oral ingestion of 50ml olive oil(OO)]. And Group C (n=9) applied standard preparation protocol for WB 18F-FDG PET/CT examination. The 18FFDG uptake in the wall of LV was qualitatively and quantitatively assessed. Results: The mean age for group A, B, and C were 49.25 ± 13.19, 56.11 ± 11.66 and 64.33 ± 7.50. The mean BMI were 22.46 ± 3.83, 25.68 ± 5.66 and 26.74 ± 4.26 respectively, while the mean FBS were 5.80 ± 1.23, 5.60 ± 1.61 and 5.73 ± 0.51 respectively. The LV uptake of 18F-FDG was significantly higher in Group C patients. There was a significant difference in mean SUVmax at mid (2.58 ± 3.97 vs 2.28 ± 2.75 vs 6.59 ± 2.09, p=0.002), basal (6.43 ± 8.57 vs 4.87 ± 3.08 vs 13.89 ± 3.77, p=0.005) and apical (6.37 ± 8.27 vs 5.33 ± 3.22 vs 11.42 ± 4.66, p=0.002) of LV. The mean normalized 18F-FDG distribution in 20-segment polar map expressed in percentage for Group B was lower in comparison to Group A and Group C (66.37% vs 63.13% vs 68.78%, p=0.04). Conclusion: Oral ingestion of edible oils leads to preference towards fatty metabolism of myocardium hence reduction in glucose uptake. 2016-08 Thesis NonPeerReviewed text en http://psasir.upm.edu.my/id/eprint/75323/1/FPSK%28M%29%202016%2040.pdf Che Nordin, Mohd Nazmi (2016) Effects of oral fatty acid on left ventricular 2-[18F] Fluoro-2-Deoxy-D-Glucose uptake during whole body positron emission and computed tomography. Masters thesis, Universiti Putra Malaysia. http://ethesis.upm.edu.my/id/eprint/12679/ Fatty acids Glucose - Synthesis Oils and fats, Edible |
| spellingShingle | Fatty acids Glucose - Synthesis Oils and fats, Edible Che Nordin, Mohd Nazmi Effects of oral fatty acid on left ventricular 2-[18F] Fluoro-2-Deoxy-D-Glucose uptake during whole body positron emission and computed tomography |
| title | Effects of oral fatty acid on left ventricular 2-[18F] Fluoro-2-Deoxy-D-Glucose uptake during whole body positron emission and computed tomography |
| title_full | Effects of oral fatty acid on left ventricular 2-[18F] Fluoro-2-Deoxy-D-Glucose uptake during whole body positron emission and computed tomography |
| title_fullStr | Effects of oral fatty acid on left ventricular 2-[18F] Fluoro-2-Deoxy-D-Glucose uptake during whole body positron emission and computed tomography |
| title_full_unstemmed | Effects of oral fatty acid on left ventricular 2-[18F] Fluoro-2-Deoxy-D-Glucose uptake during whole body positron emission and computed tomography |
| title_short | Effects of oral fatty acid on left ventricular 2-[18F] Fluoro-2-Deoxy-D-Glucose uptake during whole body positron emission and computed tomography |
| title_sort | effects of oral fatty acid on left ventricular 2-[18f] fluoro-2-deoxy-d-glucose uptake during whole body positron emission and computed tomography |
| topic | Fatty acids Glucose - Synthesis Oils and fats, Edible |
| url | http://psasir.upm.edu.my/id/eprint/75323/ http://psasir.upm.edu.my/id/eprint/75323/ http://psasir.upm.edu.my/id/eprint/75323/1/FPSK%28M%29%202016%2040.pdf |