Optimization of hydrocortisone-loaded nanoemulsion formulation using d-optimal mixture design
Optimization of hydrocortisone-loaded nanoemulsion formulation was achieved by low energy emulsification method. D-optimal mixture design was used with the variables parameters of Tween-20, lipoid S75, palm kernel oil ester (PKOE) and deionized water towards a response (viscosity). Hydrocortisone, e...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Asian Publication Corporation
2018
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/75159/ http://psasir.upm.edu.my/id/eprint/75159/1/Optimization%20of%20hydrocortisone-loaded%20nanoemulsion%20formulation%20using%20d-optimal%20mixture%20design.pdf |
| _version_ | 1848857619325779968 |
|---|---|
| author | Kong, W. Y. Salim, Norazlinaliza Masoumi, Hamid Reza Fard Basri, Mariah Da Costa, Stephanie S. Ahmad, Noraini |
| author_facet | Kong, W. Y. Salim, Norazlinaliza Masoumi, Hamid Reza Fard Basri, Mariah Da Costa, Stephanie S. Ahmad, Noraini |
| author_sort | Kong, W. Y. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Optimization of hydrocortisone-loaded nanoemulsion formulation was achieved by low energy emulsification method. D-optimal mixture design was used with the variables parameters of Tween-20, lipoid S75, palm kernel oil ester (PKOE) and deionized water towards a response (viscosity). Hydrocortisone, ethanol and phenonip were kept constant (1.0, 24 and 0.5 wt. %). The mixing rate and time were kept constant at 400 rpm and 4 h, respectively. The optimum formulation conditions were successfully predicted. From the results obtained, it shows that the higher the concentration of palm kernel oil ester, the less the viscosity of the nanoemulsion. The optimized formulation showed good stability with the viscosity of 2.85 Pa.s. The particle size, polydispersity index and zeta potential of the optimized nanoemulsion gave a result of 172.56 nm, 0.184 and -50.03 mV, respectively. The results are in agreement with the TEM micrograph. The viscosity of the optimized nanoemulsion decreased with increased shear rate, showing a shear thinning behaviour (pseudoplastic) suitable for pharmaceutical application. |
| first_indexed | 2025-11-15T12:00:26Z |
| format | Article |
| id | upm-75159 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:00:26Z |
| publishDate | 2018 |
| publisher | Asian Publication Corporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-751592019-11-27T01:40:42Z http://psasir.upm.edu.my/id/eprint/75159/ Optimization of hydrocortisone-loaded nanoemulsion formulation using d-optimal mixture design Kong, W. Y. Salim, Norazlinaliza Masoumi, Hamid Reza Fard Basri, Mariah Da Costa, Stephanie S. Ahmad, Noraini Optimization of hydrocortisone-loaded nanoemulsion formulation was achieved by low energy emulsification method. D-optimal mixture design was used with the variables parameters of Tween-20, lipoid S75, palm kernel oil ester (PKOE) and deionized water towards a response (viscosity). Hydrocortisone, ethanol and phenonip were kept constant (1.0, 24 and 0.5 wt. %). The mixing rate and time were kept constant at 400 rpm and 4 h, respectively. The optimum formulation conditions were successfully predicted. From the results obtained, it shows that the higher the concentration of palm kernel oil ester, the less the viscosity of the nanoemulsion. The optimized formulation showed good stability with the viscosity of 2.85 Pa.s. The particle size, polydispersity index and zeta potential of the optimized nanoemulsion gave a result of 172.56 nm, 0.184 and -50.03 mV, respectively. The results are in agreement with the TEM micrograph. The viscosity of the optimized nanoemulsion decreased with increased shear rate, showing a shear thinning behaviour (pseudoplastic) suitable for pharmaceutical application. Asian Publication Corporation 2018-02-28 Article NonPeerReviewed text en http://psasir.upm.edu.my/id/eprint/75159/1/Optimization%20of%20hydrocortisone-loaded%20nanoemulsion%20formulation%20using%20d-optimal%20mixture%20design.pdf Kong, W. Y. and Salim, Norazlinaliza and Masoumi, Hamid Reza Fard and Basri, Mariah and Da Costa, Stephanie S. and Ahmad, Noraini (2018) Optimization of hydrocortisone-loaded nanoemulsion formulation using d-optimal mixture design. Asian Journal of Chemistry, 30 (4). 853 - 858. ISSN 0970-7077; ESSN: 0975-427X http://www.asianjournalofchemistry.co.in/user/journal/viewarticle.aspx?ArticleID=30_4_31 10.14233/ajchem.2018.21104 |
| spellingShingle | Kong, W. Y. Salim, Norazlinaliza Masoumi, Hamid Reza Fard Basri, Mariah Da Costa, Stephanie S. Ahmad, Noraini Optimization of hydrocortisone-loaded nanoemulsion formulation using d-optimal mixture design |
| title | Optimization of hydrocortisone-loaded nanoemulsion formulation using d-optimal mixture design |
| title_full | Optimization of hydrocortisone-loaded nanoemulsion formulation using d-optimal mixture design |
| title_fullStr | Optimization of hydrocortisone-loaded nanoemulsion formulation using d-optimal mixture design |
| title_full_unstemmed | Optimization of hydrocortisone-loaded nanoemulsion formulation using d-optimal mixture design |
| title_short | Optimization of hydrocortisone-loaded nanoemulsion formulation using d-optimal mixture design |
| title_sort | optimization of hydrocortisone-loaded nanoemulsion formulation using d-optimal mixture design |
| url | http://psasir.upm.edu.my/id/eprint/75159/ http://psasir.upm.edu.my/id/eprint/75159/ http://psasir.upm.edu.my/id/eprint/75159/ http://psasir.upm.edu.my/id/eprint/75159/1/Optimization%20of%20hydrocortisone-loaded%20nanoemulsion%20formulation%20using%20d-optimal%20mixture%20design.pdf |