In vitro and in silico evaluations of diarylpentanoid series as a-glucosidase inhibitor
A series of thirty-four diarylpentanoids derivatives were synthesized and evaluated for their α-glucosidase inhibitory activity. Eleven compounds (19, 20, 21, 24, 27, 28, 29, 31, 32, 33 and 34) were found to significantly inhibit α-glucosidase in which compounds 28, 31 and 32 demonstrated the highes...
| Main Authors: | Leong, Sze Wei, Abas, Faridah, Lam, Kok Wai, Yusoff, Khatijah |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/74616/ http://psasir.upm.edu.my/id/eprint/74616/1/In%20vitro%20and%20in%20silico.pdf |
Similar Items
In-vitro and in-silico evaluations of heterocyclic-containing diarylpentanoids as Bcl-2 inhibitors against LoVo colorectal cancer cells
by: Leong, Sze Wei, et al.
Published: (2020)
by: Leong, Sze Wei, et al.
Published: (2020)
Preliminary insight on diarylpentanoids as potential antimalarials: In silico, in vitro pLDH and in vivo zebrafish toxicity assessment
by: Ramli, Amirah Hani, et al.
Published: (2024)
by: Ramli, Amirah Hani, et al.
Published: (2024)
Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxide inhibitors
by: Mohd Faudzi, S. M., et al.
Published: (2015)
by: Mohd Faudzi, S. M., et al.
Published: (2015)
Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxideinhibitors
by: Mohd Faudzi, Siti Munirah Mohd Faudzi, et al.
Published: (2015)
by: Mohd Faudzi, Siti Munirah Mohd Faudzi, et al.
Published: (2015)
Nitric oxide inhibitory activity and antioxidant evaluations
of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel
series of curcuminoid and diarylpentanoid derivatives
by: Leong, Sze Wei, et al.
Published: (2015)
by: Leong, Sze Wei, et al.
Published: (2015)
Design, synthesis, anti-inflammatory activity evaluation, and structure-activities relationship (SAR) study of diarylpentanoid derivatives
by: Leong, Sze Wei
Published: (2014)
by: Leong, Sze Wei
Published: (2014)
α-Glucosidase inhibitors: consistency of: in silico docking data with in vitro inhibitory data and inhibitory effect prediction of quercetin derivatives
by: Zhu, Jianzhong, et al.
Published: (2019)
by: Zhu, Jianzhong, et al.
Published: (2019)
Synthesis and sar study of diarylpentanoid analogues as new anti-inflammatory agents
by: Leong, Sze Wei, et al.
Published: (2014)
by: Leong, Sze Wei, et al.
Published: (2014)
Synthesis and SAR study of diarylpentanoid analogues as new anti-inflammatory agents
by: Leong, Sze Wei, et al.
Published: (2014)
by: Leong, Sze Wei, et al.
Published: (2014)
Development of diarylpentadienone analogues as alpha-glucosidase inhibitor: Synthesis, in vitro biological and in vivo toxicity evaluations, and molecular docking analysis
by: Maryam Aisyah, Abdullah, et al.
Published: (2020)
by: Maryam Aisyah, Abdullah, et al.
Published: (2020)
In silico study of mangostin compounds and its derivatives as inhibitors of α-glucosidase enzymes for anti-diabetic studies
by: Maulana, Ahmad Fariz, et al.
Published: (2022)
by: Maulana, Ahmad Fariz, et al.
Published: (2022)
Evaluation of curcumin derivatives as new cyclooxygenase-2 inhibitors via in silico and in vitro analyses
by: Abdul Bahari, Mohammad Nazri
Published: (2016)
by: Abdul Bahari, Mohammad Nazri
Published: (2016)
2-Benzoyl-6-benzylidenecyclohexanone analogs as potent dual inhibitors of acetylcholinesterase and butyrylcholinesterase
by: Sze, Wei Leong, et al.
Published: (2016)
by: Sze, Wei Leong, et al.
Published: (2016)
Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer
by: Paulraj, Felicia Simone, et al.
Published: (2019)
by: Paulraj, Felicia Simone, et al.
Published: (2019)
In silico analysis of Mentha pipertia (phyto-constituents) as HMG coa reductase and squalene synthase inhibitors
by: Narayanaswamy, Radhakrishnan, et al.
Published: (2018)
by: Narayanaswamy, Radhakrishnan, et al.
Published: (2018)
Effect of diarylpentanoid analogues on lipopolysaccharide-induced interleukin-6 and interleukin-8 gene expression in airway inflammation
by: Liew, Kong Yen, et al.
Published: (2019)
by: Liew, Kong Yen, et al.
Published: (2019)
Synthesis of diarylpentadienones and pyrazoline derivatives as potential α-glucosidase inhibitor and their antioxidant activities
by: Adam, Faruk Auwal, et al.
Published: (2023)
by: Adam, Faruk Auwal, et al.
Published: (2023)
Screening For Potential Inhibitors Of Mycobacterium Tuberculosis Isocitrate Lyase: In Silico And In Vitro Approaches
by: Lee , Yie Vern
Published: (2017)
by: Lee , Yie Vern
Published: (2017)
In Silico Prediction And In Vitro Evaluation Of Caffeic Acid And Its Derivatives As Potential Efflux Pump Inhibitor(S) In Pseudomonas Aeruginosa
by: Zakaria, Noor Zawani
Published: (2019)
by: Zakaria, Noor Zawani
Published: (2019)
In silico and in vitro-guided identification of inhibitors of alkylquinolone-dependent quorum sensing in Pseudomonas aeruginosa
by: Soukarieh, Fadi, et al.
Published: (2018)
by: Soukarieh, Fadi, et al.
Published: (2018)
Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities
by: Ka-Heng, Lee, et al.
Published: (2009)
by: Ka-Heng, Lee, et al.
Published: (2009)
Benzalhydantoin derivative-based inhibitors of eight receptor tyrosine kinases: synthesis, in-vitro, and in-silico study
by: Muhammad Naufal,, et al.
Published: (2025)
by: Muhammad Naufal,, et al.
Published: (2025)
Identification of alpha-glucosidase inhibitors in Cosmos caudatus leaves using GC-MS based metabolomics
by: Khatib, Alfi, et al.
Published: (2015)
by: Khatib, Alfi, et al.
Published: (2015)
Chemopreventive effects of a curcumin‐like diarylpentanoid [2,6‐bis(2,5‐dimethoxybenzylidene)cyclohexanone] in cellular targets of rheumatoid arthritis in vitro
by: Lee, Ka Heng, et al.
Published: (2015)
by: Lee, Ka Heng, et al.
Published: (2015)
A synthetic curcumin-like diarylpentanoid analog inhibits rhinovirus infection in H1 hela cells via multiple antiviral mechanisms
by: Liew, Kong Yen, et al.
Published: (2024)
by: Liew, Kong Yen, et al.
Published: (2024)
α-glucosidase inhibitors isolated from Mimosa pudica L.
by: Tasnuva, S. T., et al.
Published: (2017)
by: Tasnuva, S. T., et al.
Published: (2017)
Potential beta-glucosidase inhibitor from Malaysian medical plants
by: Ahmad Barkat, Anumsima, et al.
Published: (2009)
by: Ahmad Barkat, Anumsima, et al.
Published: (2009)
Identification of α-glucosidase inhibitory compounds from Curcuma mangga fractions
by: Awin, Tahani M., et al.
Published: (2020)
by: Awin, Tahani M., et al.
Published: (2020)
Inhibition of prostaglandin E-2 production by synthetic minor prenylated chalcones and flavonoids: Synthesis, biological activity, crystal structure, and in silico evaluation
by: Kamal, Rullah, et al.
Published: (2014)
by: Kamal, Rullah, et al.
Published: (2014)
Inhibition of prostaglandin E2 production by synthetic minor prenylated chalcones and flavonoids: synthesis, biological activity, crystal structure, and in silico evaluation
by: Rullah, Kamal, et al.
Published: (2014)
by: Rullah, Kamal, et al.
Published: (2014)
Molecular docking analysis of curcumin analogues as human neutrophil elastase inhibitors
by: Narayanaswamy, Radhakrishnan, et al.
Published: (2014)
by: Narayanaswamy, Radhakrishnan, et al.
Published: (2014)
In silico study of carvone derivatives as potential neuraminidase inhibitors
by: Jusoh, Noorakmar, et al.
Published: (2018)
by: Jusoh, Noorakmar, et al.
Published: (2018)
α-glucosidase inhibitory and antioxidant activities of different ipomoea aquatica cultivars and lc–ms/ms profiling of the active cultivar
by: Lawal, Umar, et al.
Published: (2016)
by: Lawal, Umar, et al.
Published: (2016)
α‐Glucosidase inhibitory and antioxidant activities of different ipomoea aquatica cultivars and LC–MS/MS profiling of the active cultivar
by: Lawal, Umar, et al.
Published: (2017)
by: Lawal, Umar, et al.
Published: (2017)
In silico and in vitro antiviral activity evaluation of prodigiosin from Serratia marcescens against enterovirus 71
by: Muhamad Fakrulnizam Abd Aziz,, et al.
Published: (2022)
by: Muhamad Fakrulnizam Abd Aziz,, et al.
Published: (2022)
Antinociceptive activities of a novel diarylpentanoid analogue, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol, and its possible mechanisms of action in mice
by: Ong, Hui Ming, et al.
Published: (2021)
by: Ong, Hui Ming, et al.
Published: (2021)
In-silico characterization of glycosyl hydrolase family 1 β glucosidase from Trichoderma asperellum UPM1
by: Mohamad Sobri, Mohamad Farhan, et al.
Published: (2020)
by: Mohamad Sobri, Mohamad Farhan, et al.
Published: (2020)
New quinoxalinone inhibitors targeting secreted phospholipase A2 and alpha-glucosidase
by: Alasmary, Fatmah A.S., et al.
Published: (2017)
by: Alasmary, Fatmah A.S., et al.
Published: (2017)
The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model
by: Hui, Ming Ong, et al.
Published: (2021)
by: Hui, Ming Ong, et al.
Published: (2021)
Screening Of Α-Glucosidase Inhibitors From Black Soybean Extract And Study On Their Inhibitory Mechanisms
by: Zheng, Yu
Published: (2024)
by: Zheng, Yu
Published: (2024)
Similar Items
-
In-vitro and in-silico evaluations of heterocyclic-containing diarylpentanoids as Bcl-2 inhibitors against LoVo colorectal cancer cells
by: Leong, Sze Wei, et al.
Published: (2020) -
Preliminary insight on diarylpentanoids as potential antimalarials: In silico, in vitro pLDH and in vivo zebrafish toxicity assessment
by: Ramli, Amirah Hani, et al.
Published: (2024) -
Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxide inhibitors
by: Mohd Faudzi, S. M., et al.
Published: (2015) -
Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxideinhibitors
by: Mohd Faudzi, Siti Munirah Mohd Faudzi, et al.
Published: (2015) -
Nitric oxide inhibitory activity and antioxidant evaluations
of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel
series of curcuminoid and diarylpentanoid derivatives
by: Leong, Sze Wei, et al.
Published: (2015)