In silico-guided sequence modifications of K-ras epitopes improve immunological outcome against G12V and G13D mutant KRAS antigens

In silico-guided sequence modifications of K-ras epitopes improve immunological outcome against G12V and G13D mutant KRAS antigens

Background: Somatic point substitution mutations in the KRAS proto-oncogene primarily affect codons 12/13 where glycine is converted into other amino acids, and are highly prevalent in pancreatic, colorectal, and non-small cell lung cancers. These cohorts are non-responsive to anti-EGFR treatments,...

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Main Authors: Wee, Allan Ren Ng, Tan, Pei Jun, Pui, Winfrey Yee Hoo, Liew, Dek Shen, Yee, Michelle Mun Teo, Pui, Yan Siak, Ng, Sze Man, Tan, Ee Wern, Abdul Rahim, Raha, Lay, Renee Hong Lim, Ai, Adelene Lian Song, Lian, Lionel Aun In
Format: Article
Language:English
Published: PeerJ 2018
Online Access:http://psasir.upm.edu.my/id/eprint/74613/
http://psasir.upm.edu.my/id/eprint/74613/1/In%20silico-guided%20sequence%20modifications%20of%20K-ras%20epitopes%20improve%20immunological%20outcome%20against%20G12V%20and%20G13D%20mutant%20KRAS%20antigens.pdf

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