Impact of prolonged reduced-pressure condition prior to precursor labeling on the labeling efficiency of F-18 fluorocholine synthesis
Objective: The goal of this preliminary work was to observe the impact of the prolonged reduced-pressure condition prior to labeling stage on the F-18 Fluorocholine labeling yield at the end of synthesis.Methods: At this present work, the condition inside the reactor vial prior to labeling stage was...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
2018
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/74575/ http://psasir.upm.edu.my/id/eprint/74575/1/Impact%20of%20prolonged.pdf |
| _version_ | 1848857521561796608 |
|---|---|
| author | Hassan, Hishar Hanafi, Muhammad Hafiz A S, Fathinul Fikri |
| author_facet | Hassan, Hishar Hanafi, Muhammad Hafiz A S, Fathinul Fikri |
| author_sort | Hassan, Hishar |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Objective: The goal of this preliminary work was to observe the impact of the prolonged reduced-pressure condition prior to labeling stage on the F-18 Fluorocholine labeling yield at the end of synthesis.Methods: At this present work, the condition inside the reactor vial prior to labeling stage was manipulated. In the first technique of syntheses of F-18 Fluorocholine, the condition inside the reactor vial was set at 0 atmospheric pressure (0 atm) while in the second technique the condition inside the reactor was set at reduced-pressure (between-0.65 to-0.85 bars) with the delay time of 120 seconds. At the end of the synthesis, the impact of the prolonged reduced-pressure condition prior to precursor labeling was measured in terms of labeling yield of F-18 Fluorocholine. Results: With the second technique, the labeling yield of F-18 Fluorocholine was elevated from 9.7% (the first technique) to 24.3%.Conclusion: This preliminary work indicates that delay in a reduced-pressure condition prior to labeling step has greatly improved the labeling yield of F-18 Fluorocholine at the end of synthesis. Using this approach, the labeling yield of F-18 Fluorocholine was elevated from 7.5% to 24.3%. |
| first_indexed | 2025-11-15T11:58:52Z |
| format | Article |
| id | upm-74575 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:58:52Z |
| publishDate | 2018 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-745752020-03-17T08:13:54Z http://psasir.upm.edu.my/id/eprint/74575/ Impact of prolonged reduced-pressure condition prior to precursor labeling on the labeling efficiency of F-18 fluorocholine synthesis Hassan, Hishar Hanafi, Muhammad Hafiz A S, Fathinul Fikri Objective: The goal of this preliminary work was to observe the impact of the prolonged reduced-pressure condition prior to labeling stage on the F-18 Fluorocholine labeling yield at the end of synthesis.Methods: At this present work, the condition inside the reactor vial prior to labeling stage was manipulated. In the first technique of syntheses of F-18 Fluorocholine, the condition inside the reactor vial was set at 0 atmospheric pressure (0 atm) while in the second technique the condition inside the reactor was set at reduced-pressure (between-0.65 to-0.85 bars) with the delay time of 120 seconds. At the end of the synthesis, the impact of the prolonged reduced-pressure condition prior to precursor labeling was measured in terms of labeling yield of F-18 Fluorocholine. Results: With the second technique, the labeling yield of F-18 Fluorocholine was elevated from 9.7% (the first technique) to 24.3%.Conclusion: This preliminary work indicates that delay in a reduced-pressure condition prior to labeling step has greatly improved the labeling yield of F-18 Fluorocholine at the end of synthesis. Using this approach, the labeling yield of F-18 Fluorocholine was elevated from 7.5% to 24.3%. 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/74575/1/Impact%20of%20prolonged.pdf Hassan, Hishar and Hanafi, Muhammad Hafiz and A S, Fathinul Fikri (2018) Impact of prolonged reduced-pressure condition prior to precursor labeling on the labeling efficiency of F-18 fluorocholine synthesis. International Journal of Pharmacy and Pharmaceutical Sciences, 10 (4). 143 - 145. ISSN 0975-1491 10.22159/ijpps.2018v10i4.23057 |
| spellingShingle | Hassan, Hishar Hanafi, Muhammad Hafiz A S, Fathinul Fikri Impact of prolonged reduced-pressure condition prior to precursor labeling on the labeling efficiency of F-18 fluorocholine synthesis |
| title | Impact of prolonged reduced-pressure condition prior to precursor labeling on the labeling efficiency of F-18 fluorocholine synthesis |
| title_full | Impact of prolonged reduced-pressure condition prior to precursor labeling on the labeling efficiency of F-18 fluorocholine synthesis |
| title_fullStr | Impact of prolonged reduced-pressure condition prior to precursor labeling on the labeling efficiency of F-18 fluorocholine synthesis |
| title_full_unstemmed | Impact of prolonged reduced-pressure condition prior to precursor labeling on the labeling efficiency of F-18 fluorocholine synthesis |
| title_short | Impact of prolonged reduced-pressure condition prior to precursor labeling on the labeling efficiency of F-18 fluorocholine synthesis |
| title_sort | impact of prolonged reduced-pressure condition prior to precursor labeling on the labeling efficiency of f-18 fluorocholine synthesis |
| url | http://psasir.upm.edu.my/id/eprint/74575/ http://psasir.upm.edu.my/id/eprint/74575/ http://psasir.upm.edu.my/id/eprint/74575/1/Impact%20of%20prolonged.pdf |