The protective effects of a synthetic geranyl acetophenone in a cellular model of TNF-α-induced pulmonary epithelial barrier dysfunction
Alveolar epithelial barrier dysfunction contributes to lung edema and can lead to acute lung injury (ALI). The features include increased epithelial permeability, upregulation of inflammatory mediators and downregulation of junctional complex molecules; these changes are often induced by inflammatio...
| Main Authors: | Tee, Yee Sim, Harith, Hanis Hazeera, Tham, Chau Ling, Md Hashim, Nur Fariesha, Shaari, Khozirah, Sulaiman, Mohd Roslan, Israf Ali, Daud Ahmad |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI
2018
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/74251/ http://psasir.upm.edu.my/id/eprint/74251/1/The%20protective%20effects%20of%20a%20synthetic%20geranyl%20acetophenone%20in%20a%20cellular%20model%20of%20TNF-%CE%B1-induced%20pulmonary%20epithelial%20barrier%20dysfunction.pdf |
Similar Items
Blockade of eosinophil-induced bronchial epithelial-mesenchymal transition with a geranyl acetophenone in a coculture model
by: Lee, Yu Zhao, et al.
Published: (2017)
by: Lee, Yu Zhao, et al.
Published: (2017)
The geranyl acetophenone tHGA attenuates human bronchial smooth muscle proliferation via inhibition of AKT phosphorylation
by: Yap, Hui Min, et al.
Published: (2018)
by: Yap, Hui Min, et al.
Published: (2018)
Pharmacological properties of 2,4,6-Trihydroxy-3-geranyl acetophenone and the underlying signaling pathways: progress and prospects
by: Chan, Yee Han, et al.
Published: (2021)
by: Chan, Yee Han, et al.
Published: (2021)
Effects of synthetic 2, 4, 6-trihydroxy-3-geranylacetophenone upon TNF-α-induced epithelial dysfunction
by: Sim, Tee Yee
Published: (2016)
by: Sim, Tee Yee
Published: (2016)
Airway remodeling blockade with an orally active geranyl acetophenone
by: Lee, Yu Zhao
Published: (2017)
by: Lee, Yu Zhao
Published: (2017)
Barrier protective effects of 2,4,6-trihydroxy-3-geranyl acetophenone on lipopolysaccharides-stimulated inflammatory responses in human umbilical vein endothelial cells
by: Yi, Joong Chong, et al.
Published: (2016)
by: Yi, Joong Chong, et al.
Published: (2016)
Barrier protective effects of 2,4,6-trihydroxy-3-geranyl acetophenone on lipopolysaccharides-stimulated inflammatory responses in human umbilical vein endothelial cells
by: Chong, Yi Joong, et al.
Published: (2016)
by: Chong, Yi Joong, et al.
Published: (2016)
Regulation of ige-mediated mast cell degranulation in allergy by geranyl acetophenone
by: Tan, Ji Wei
Published: (2017)
by: Tan, Ji Wei
Published: (2017)
Oral and topical administration of a geranyl acetophenone attenuates DNCB-induced atopic dermatitis-like skin lesions in BALB/c mice
by: Mohd Kasim, Vivi Nur Khalieda, et al.
Published: (2024)
by: Mohd Kasim, Vivi Nur Khalieda, et al.
Published: (2024)
Oral and topical administration of a geranyl acetophenone attenuates DNCB‑induced atopic dermatitis‑like skin lesions in BALB/c mice
by: Mohd Kasim, Vivi Nur Khalieda, et al.
Published: (2024)
by: Mohd Kasim, Vivi Nur Khalieda, et al.
Published: (2024)
Mast cell stabilizing effect of a geranyl acetophenone in dengue virus infection using in vitro model of DENV3-induced RBL-2H3 cells
by: Tan, Ji Wei, et al.
Published: (2019)
by: Tan, Ji Wei, et al.
Published: (2019)
Drug repurposing of clinically approved drugs to target epithelial-mesenchymal transition using molecular docking approach
by: Chun Hao, Ong, et al.
Published: (2023)
by: Chun Hao, Ong, et al.
Published: (2023)
NADPH oxidase mediates TNF-α-evoked in vitro brain barrier dysfunction: roles of apoptosis and time
by: Abdullah, Zuraidah, et al.
Published: (2014)
by: Abdullah, Zuraidah, et al.
Published: (2014)
The synthetic curcuminoid BHMC restores endotoxin-stimulated HUVEC dysfunction: specific disruption on enzymatic activity of p38 MAPK
by: Chau, Ling Tham, et al.
Published: (2015)
by: Chau, Ling Tham, et al.
Published: (2015)
Trichostrongylus colubriformis extract upregulates TNF-α receptor expression and enhances TNF-α sensitivity of L929 cells
by: Riffkin, M.C., et al.
Published: (2000)
by: Riffkin, M.C., et al.
Published: (2000)
Effects of 2,4,6-trihydroxy-3-geranyl acetophenone on growth factor-induced human bronchial smooth muscle cell proliferation in asthma
by: Yap, Hui Min
Published: (2018)
by: Yap, Hui Min
Published: (2018)
Δ9-tetrahydrocannabinol reverses TNFα-induced increase in airway epithelial cell permeability through CB2 receptors
by: Shang, Valerie C.M., et al.
Published: (2016)
by: Shang, Valerie C.M., et al.
Published: (2016)
In vitro protective effects of 2,4,6-trihydroxy-3-geranyl acetophenone on junctional protein disruption and the underlying signaling pathways in lipopolysaccharide-induced endothelial hyperpermeability
by: Chan, Yee Han
Published: (2022)
by: Chan, Yee Han
Published: (2022)
Hits-to-lead optimization of the natural compound 2,4,6-trihydroxy-3-geranyl-acetophenone (tHGA) as a potent LOX Inhibitor: synthesis, structure-activity relationship (SAR) study and computational assignment
by: Ng, Chean Hui, et al.
Published: (2018)
by: Ng, Chean Hui, et al.
Published: (2018)
Cryptotanshinone inhibits TNF-α-induced early atherogenic events in vitro
by: Ahmad, Zuraini, et al.
Published: (2016)
by: Ahmad, Zuraini, et al.
Published: (2016)
LAT is essential for the mast cell stabilising effect of tHGA in IgE-mediated mast cell activation
by: Tan, Ji Wei, et al.
Published: (2017)
by: Tan, Ji Wei, et al.
Published: (2017)
Computational Studies On Muoniated Acetophenones
by: Mohamad Rosli, Nur Aisyah
Published: (2020)
by: Mohamad Rosli, Nur Aisyah
Published: (2020)
Inhibition of TNF-α protects in vitro brain barrier from ischaemic damage
by: Abdullah, Zuraidah, et al.
Published: (2015)
by: Abdullah, Zuraidah, et al.
Published: (2015)
Anti-allergic activity of 2,4,6-trihydroxy-3-geranylacetophenone (tHGA) via attenuation of IgE-mediated mast cell activation and inhibition of passive systemic anaphylaxis
by: Tan, Ji Wei, et al.
Published: (2017)
by: Tan, Ji Wei, et al.
Published: (2017)
Differential regulation of LPS-mediated VE-cadherin disruption in human endothelial cells and the underlying signaling pathways: a mini review
by: Chan, Yee Han, et al.
Published: (2020)
by: Chan, Yee Han, et al.
Published: (2020)
A synthetic curcuminoid analogue, 2,6-Bis-4-(Hydroxyl-3-Methoxybenzylidine)-Cyclohexanone (BHMC) ameliorates acute airway inflammation of allergic asthma in ovalbumin-sensitized mice
by: Tham, Chau Ling, et al.
Published: (2021)
by: Tham, Chau Ling, et al.
Published: (2021)
2,4,6,-trihydroxy-3-geranylacetophenone (tHGA) suppresses chronic allergic airway inflammation in ovalbumin-sensitized mice via intraperitoneal route
by: Ismail, Norazren, et al.
Published: (2019)
by: Ismail, Norazren, et al.
Published: (2019)
Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis
by: Treude, Fabian, et al.
Published: (2014)
by: Treude, Fabian, et al.
Published: (2014)
Use of the curcumin analog BHMC in the treatment of endothelial dysfunction and related disorders
by: Israf Ali, Daud Ahmad, et al.
Published: (2012)
by: Israf Ali, Daud Ahmad, et al.
Published: (2012)
TGF-β-induced fibrosis: a review on the underlying mechanism and potential therapeutic strategies
by: Ong, Chun Hao, et al.
Published: (2021)
by: Ong, Chun Hao, et al.
Published: (2021)
IL-15 promotes human myogenesis and mitigates the detrimental effects of TNFα on myotube development
by: O’Leary, Mary F., et al.
Published: (2017)
by: O’Leary, Mary F., et al.
Published: (2017)
Suppression of PKC-α attenuates TNF-α-evoked cerebral barrier breakdown via regulations of MMP-2 and plasminogen–plasmin system
by: Abdullah, Zuraidah, et al.
Published: (2016)
by: Abdullah, Zuraidah, et al.
Published: (2016)
PINX1 and TERT are required for TNF-α-induced airway smooth muscle chemokine gene expression
by: Deacon, Karl, et al.
Published: (2018)
by: Deacon, Karl, et al.
Published: (2018)
Barrier protective effect of asiatic acid in TNF-α-induced activation of human aortic endothelial cells
by: Fong, Lai Yen, et al.
Published: (2016)
by: Fong, Lai Yen, et al.
Published: (2016)
Barrier protective effects of asiatic acid in TNF-α-induced activation of human aortic endothelial cells
by: Lai, Yen Fong, et al.
Published: (2016)
by: Lai, Yen Fong, et al.
Published: (2016)
An eco-friendly and new facile method for synthesis of prenylated or geranylated acylphloroglucinol-based xanthenones
by: Tamil Segaran, Raaginie, et al.
Published: (2024)
by: Tamil Segaran, Raaginie, et al.
Published: (2024)
Characterisation of TNF block haplotypes affecting the production of TNF and LTA
by: Tan, J., et al.
Published: (2011)
by: Tan, J., et al.
Published: (2011)
Crosstalk between signaling pathways involved in the regulation of airway smooth muscle cell hyperplasia
by: Yap, Hui Min, et al.
Published: (2019)
by: Yap, Hui Min, et al.
Published: (2019)
Inhibition of epithelial CC-family chemokine synthesis by the synthetic chalcone DMPF-1 via disruption of NF-κB nuclear translocation and suppression of experimental asthma in mice
by: Rajajendram, Revathee, et al.
Published: (2015)
by: Rajajendram, Revathee, et al.
Published: (2015)
Photocrosslinkable gelatin hydrogels modulate the production of the major pro-inflammatory cytokine, TNF-α, by human mononuclear cells
by: Donaldson, Amy R., et al.
Published: (2018)
by: Donaldson, Amy R., et al.
Published: (2018)
Similar Items
-
Blockade of eosinophil-induced bronchial epithelial-mesenchymal transition with a geranyl acetophenone in a coculture model
by: Lee, Yu Zhao, et al.
Published: (2017) -
The geranyl acetophenone tHGA attenuates human bronchial smooth muscle proliferation via inhibition of AKT phosphorylation
by: Yap, Hui Min, et al.
Published: (2018) -
Pharmacological properties of 2,4,6-Trihydroxy-3-geranyl acetophenone and the underlying signaling pathways: progress and prospects
by: Chan, Yee Han, et al.
Published: (2021) -
Effects of synthetic 2, 4, 6-trihydroxy-3-geranylacetophenone upon TNF-α-induced epithelial dysfunction
by: Sim, Tee Yee
Published: (2016) -
Airway remodeling blockade with an orally active geranyl acetophenone
by: Lee, Yu Zhao
Published: (2017)