The molecular targets and anti-invasive effects of 2,6-bis-(4-hydroxyl-3methoxybenzylidine) cyclohexanone or BHMC in MDA-MB-231 human breast cancer cells

QR Code

The molecular targets and anti-invasive effects of 2,6-bis-(4-hydroxyl-3methoxybenzylidine) cyclohexanone or BHMC in MDA-MB-231 human breast cancer cells

In order to metastasize, tumor cells need to migrate and invade the surrounding tissues. It is important to identify compound(s) capable of disrupting the metastasis of invasive cancer cells, especially for hindering invadopodia formation, so as to provide anti-metastasis targeted therapy. Invadopod...

Full description

Bibliographic Details
Main Authors:	Harun, Siti Nor Aini, Israf Ali, Daud Ahmad, Chau, Ling Tham, Kok, Wai Lam, Cheema, Manraj Singh, Md Hashim, Nur Fariesha
Format:	Article
Language:	English
Published:	Multidisciplinary Digital Publishing Institute 2018
Online Access:	http://psasir.upm.edu.my/id/eprint/74229/ http://psasir.upm.edu.my/id/eprint/74229/1/The%20molecular%20targets%20and%20anti.pdf

Similar Items

A synthetic curcuminoid analogue, 2,6-Bis-4-(Hydroxyl-3-Methoxybenzylidine)-Cyclohexanone (BHMC) ameliorates acute airway inflammation of allergic asthma in ovalbumin-sensitized mice
by: Tham, Chau Ling, et al.
Published: (2021)

Anti-invasive effects of 2,6-bis-(4-hydroxyl-3methoxybenzylidine) cyclohexanone and its molecular targets associated with invadopodia formation in MDA-MB-231 human breast cancer cells
by: Harun, Siti Nor Aini
Published: (2018)

Cytotoxicity, proliferation and migration effects of 2,6-bis-(4-hydroxyl-3-methoxybenzylidine)cyclohexanone (BHMC) on human liver cancer, HepG2 cells
by: Mohd Shafiee, Muhammad Aminuddin, et al.
Published: (2024)

The effects of a synthetic curcuminoid analogue,2,6-bis-(4-hydroxyl-3-methoxybenzylidine)cyclohexanone on proinflammatorysignaling pathways and CLP-induced lethal sepsis in mice.
by: Chau, Ling Tham, et al.
Published: (2011)

Development and validation of a bioanalytical method for quantification of 2,6-bis-(4-hydroxy-3-methoxybenzylidene)-cyclohexanone (BHMC) in rat plasma
by: Lee, Yu Zhao, et al.
Published: (2012)

Cytotoxic effect of 2,6-bis(4-hydroxy-3-methoxybenzylidene) cyclohexanone (BHMC) and curcumin on human liver cancer cells, HepG2
by: Syed Alwi, Sharifah Sakinah, et al.
Published: (2019)

Ampelopsin E reduces the invasiveness of the triple negative breast cancer cell line, MDA-MB-231
by: Tieng, Francis Yew Fu, et al.
Published: (2019)

Citral induced apoptosis in MDA-MB-231 spheroid cells
by: Rosli, Rozita, et al.
Published: (2018)

Anti cancer activity of plant extracts on MDA-MB231
by: Yussoff, Seri Wahyuni
Published: (2015)

The In Vivo Anti-Tumor Effect of Curcumin Derivative (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene) Cyclohexanone (BHMC) on 4T1 Breast Cancer Cells
by: Nursyamirah, Abd Razak, et al.
Published: (2017)

The in vivo anti-tumor effect of curcumin derivative (2 E,6 E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) on 4T1 breast cancer cells
by: Razak, Nursyamirah Abd, et al.
Published: (2017)

Induction of apoptosis and regulation of MicroRNA expression by (2E,6E)-2,6-bis-(4-hydroxy-3-methoxybenzylidene)-cyclohexanone (BHMC) treatment on MCF-7 breast cancer cells
by: Yeap, Swee Keong, et al.
Published: (2021)

Investigating the effect of andrographolide on HMGCR protein expression in MDA-MB-231
by: Abdulateef, Al-Hakam Ahmed
Published: (2019)

Induction of apoptosis and regulation ofMicroRNA expression by (2E,6E)-2,6-bis-(4-hydroxy-3-methoxybenzylidene)- cyclohexanone (BHMC) treatment on MCF-7 breast cancer cells
by: Yeap, S. K., et al.
Published: (2021)

The effects of valproic acid on navi.5 gene expression in mda-mb- 231 cells
by: Kandivan, Hemalatha
Published: (2016)

Effects of ampelopsin E towards the invasiveness of triple negative breast cancer cell line, MDA-MB-231
by: Tieng, Francis Yew Fu
Published: (2019)

Flavokawain B Induced cytotoxicity in Two Breast Cancer Cell Lines, MCF-7 and MDA-MB231 and Inhibited the Metastatic Potential of MDA-MB231 via the Regulation of Several Tyrosine Kinases In vitro
by: Nadiah, Abu, et al.
Published: (2016)

Flavokawain B induced cytotoxicity in two breast cancer cell lines, MCF-7 and MDA-MB231 and inhibited the metastatic potential of MDA-MB231 via the regulation of several tyrosine kinases in vitro
by: Abu, Nadiah, et al.
Published: (2016)

The synthetic curcuminoid BHMC restores endotoxin-stimulated HUVEC dysfunction: specific disruption on enzymatic activity of p38 MAPK
by: Chau, Ling Tham, et al.
Published: (2015)

Use of the curcumin analog BHMC in the treatment of endothelial dysfunction and related disorders
by: Israf Ali, Daud Ahmad, et al.
Published: (2012)

Effect of linoleic acid of Nigella sativa on MDA-MB-231 human breast cancer cells.
by: G. K., Hasanzadeh, et al.
Published: (2011)

Chemopreventive effects of a curcumin‐like diarylpentanoid [2,6‐bis(2,5‐dimethoxybenzylidene)cyclohexanone] in cellular targets of rheumatoid arthritis in vitro
by: Lee, Ka Heng, et al.
Published: (2015)

Flavokawain a induces apoptosis in MCF-7 and MDA-MB231 and inhibits the metastatic process in vitro
by: Nadiah, Abu, et al.
Published: (2014)

Flavokawain A induces apoptosis in MCF-7 and MDA-MB231 and inhibits the metastatic process in vitro
by: Abu, Nadiah, et al.
Published: (2014)

The effects of 2-methoxy-1,4-naphthoquinone (mnq) on glucose metabolism of mda-mb-231 cells
by: Daud, Syukriyah Mat
Published: (2020)

Effects of knocking-down HIF-la on migration in human breast cancer cell MDA-MB-231
by: Rashid, Nur Sabrina Abd
Published: (2015)

Antinociceptive activity of a synthetic curcuminoid analogue, 2,6-bis-(4-hydroxy-3-methoxybenzylidene)cyclohexanone, on nociception-induced models in mice.
by: Lee, Ming Tatt, et al.
Published: (2012)

Downregulation of RhoGDIα increased migration and invasion of ER+ MCF7 and ER− MDA-MB-231 breast cancer cells.
by: Hooshmand, Somayeh, et al.
Published: (2013)

Design, synthesis of flavokawain b derivative and their cytotoxic effects on MCF-7 and MDA-MB-231 cell lines
by: Addila, Abu Bakar
Published: (2018)

Oncolytic Effect Of Newcastle Disease Virus On The Mcf-7 And Mda-Mb-231 Breast Cancer Cell Lines
by: Meyyappan, Narayani
Published: (2003)

Curcumin from turmeric (Curcuma longa) induced apoptosis in human mammary carcinoma cells (MDA-MB-231)
by: Saiful Yazan, Latifah, et al.
Published: (2006)

The molecular mechanism of the anticancer effect of Artonin E in MDA-MB 231 triple negative breast cancer cells
by: Etti, Imaobong Christopher, et al.
Published: (2017)

Treatment of MCF-7 and MDA-MB-231 human breast cancer cell lines with erythropoietin, doxorubicin and their combination
by: Radwan, Esam M.
Published: (2015)

Establishment of hypoxia-induced invadopodia model and phenotype characterisation of MDA-MB- 231 breast cancer cell line
by: Hamad, Hamad Hamad Ali
Published: (2019)

Effects of silencing dishevelled 1, 2 and 3 mRNA expression on MDA-MB-231 cell migration and invasion using siRNAs
by: Khoo, Samuel Leon Juan
Published: (2015)

Identification of potential chemical substrates as fuel for hypoxic tumors that may be linked to invadopodium formation in hypoxia-induced MDA-MB-231 breast-cancer cell line
by: Hamad, Hamad Ali, et al.
Published: (2020)

Assessment of cytotoxicity potency of paclitaxel in combination with Clinacanthus Nutans extracts on human MDA-MB-231 breast cancer cells
by: Nur Hasnieza Mohd Rosli,, et al.
Published: (2018)

Extracts of Hypsizygus tessellatus (white var.) caps inhibited MCF-7 and MDA-MB-231 cell lines proliferation
by: Ukaegbu, Chinonso Ishmael, et al.
Published: (2018)

Effect of recombinant human erythropoietin and doxorubicin in combination on the proliferation of MCF-7 and MDA-mb231 breast cancer cells
by: Radwan, Esam M., et al.
Published: (2016)

mRNA expression of Somatostatin receptors 1-5 in MCF7 and MDA-MB231 breast cancer cells
by: Mahmoud, Alkhansa, et al.
Published: (2021)