Targeting energy metabolism to eliminate cancer cells
Adaptive metabolic responses toward a low oxygen environment are essential to maintain rapid proliferation and are relevant for tumorigenesis. Reprogramming of core metabolism in tumors confers a selective growth advantage such as the ability to evade apoptosis and/or enhance cell proliferation and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/74082/ http://psasir.upm.edu.my/id/eprint/74082/1/Targeting%20energy%20metabolism%20to%20eliminate%20cancer%20cells.pdf |
| _version_ | 1848857430548545536 |
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| author | Shahruzaman, Shazwin Hani Fakurazi, Sharida Maniam, Sandra |
| author_facet | Shahruzaman, Shazwin Hani Fakurazi, Sharida Maniam, Sandra |
| author_sort | Shahruzaman, Shazwin Hani |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Adaptive metabolic responses toward a low oxygen environment are essential to maintain rapid proliferation and are relevant for tumorigenesis. Reprogramming of core metabolism in tumors confers a selective growth advantage such as the ability to evade apoptosis and/or enhance cell proliferation and promotes tumor growth and progression. One of the mechanisms that contributes to tumor growth is the impairment of cancer cell metabolism. In this review, we outline the small-molecule inhibitors identified over the past decade in targeting cancer cell metabolism and the usage of some of these molecules in clinical trials. |
| first_indexed | 2025-11-15T11:57:26Z |
| format | Article |
| id | upm-74082 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:57:26Z |
| publishDate | 2018 |
| publisher | Dove Medical Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-740822020-04-26T23:01:35Z http://psasir.upm.edu.my/id/eprint/74082/ Targeting energy metabolism to eliminate cancer cells Shahruzaman, Shazwin Hani Fakurazi, Sharida Maniam, Sandra Adaptive metabolic responses toward a low oxygen environment are essential to maintain rapid proliferation and are relevant for tumorigenesis. Reprogramming of core metabolism in tumors confers a selective growth advantage such as the ability to evade apoptosis and/or enhance cell proliferation and promotes tumor growth and progression. One of the mechanisms that contributes to tumor growth is the impairment of cancer cell metabolism. In this review, we outline the small-molecule inhibitors identified over the past decade in targeting cancer cell metabolism and the usage of some of these molecules in clinical trials. Dove Medical Press 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/74082/1/Targeting%20energy%20metabolism%20to%20eliminate%20cancer%20cells.pdf Shahruzaman, Shazwin Hani and Fakurazi, Sharida and Maniam, Sandra (2018) Targeting energy metabolism to eliminate cancer cells. Cancer Management and Research, 2018 (10). 2325 - 2335. ISSN 1179-1322; ESSN: 1179-1322 10.2147/CMAR.S167424 |
| spellingShingle | Shahruzaman, Shazwin Hani Fakurazi, Sharida Maniam, Sandra Targeting energy metabolism to eliminate cancer cells |
| title | Targeting energy metabolism to eliminate cancer cells |
| title_full | Targeting energy metabolism to eliminate cancer cells |
| title_fullStr | Targeting energy metabolism to eliminate cancer cells |
| title_full_unstemmed | Targeting energy metabolism to eliminate cancer cells |
| title_short | Targeting energy metabolism to eliminate cancer cells |
| title_sort | targeting energy metabolism to eliminate cancer cells |
| url | http://psasir.upm.edu.my/id/eprint/74082/ http://psasir.upm.edu.my/id/eprint/74082/ http://psasir.upm.edu.my/id/eprint/74082/1/Targeting%20energy%20metabolism%20to%20eliminate%20cancer%20cells.pdf |