Seizure induced by tranexamic acid in a patient with chronic kidney disease on maintenance dialysis
Tranexamic acid (TXA) is an antifibrinolytic agent commonly used to achieve hemostasis. However, there have been a few case reports suggesting that high-dose intravenous TXA has epileptogenic property. In patients with renal impairment, even administering the usual recommended dose of TXA can induce...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/73846/ http://psasir.upm.edu.my/id/eprint/73846/1/Selected%20organs%20of%20marine%20mussels%20as%20accurate%20biomonitors%20of%20metal%20bioavailability%20and%20contamination%20in%20the%20coastal%20waters%20challenges.pdf |
| _version_ | 1848857377329119232 |
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| author | Fuah, Kar Wah Lim, Christopher Thiam Seong Pang, Daniel C. L. Jin, Shyan Wong |
| author_facet | Fuah, Kar Wah Lim, Christopher Thiam Seong Pang, Daniel C. L. Jin, Shyan Wong |
| author_sort | Fuah, Kar Wah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Tranexamic acid (TXA) is an antifibrinolytic agent commonly used to achieve hemostasis. However, there have been a few case reports suggesting that high-dose intravenous TXA has epileptogenic property. In patients with renal impairment, even administering the usual recommended dose of TXA can induce seizure episodes. We present here a patient on hemodialysis who developed seizures after receiving two doses of TXA over 5 h period. |
| first_indexed | 2025-11-15T11:56:35Z |
| format | Article |
| id | upm-73846 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:56:35Z |
| publishDate | 2018 |
| publisher | Wolters Kluwer Medknow Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-738462020-05-20T09:08:59Z http://psasir.upm.edu.my/id/eprint/73846/ Seizure induced by tranexamic acid in a patient with chronic kidney disease on maintenance dialysis Fuah, Kar Wah Lim, Christopher Thiam Seong Pang, Daniel C. L. Jin, Shyan Wong Tranexamic acid (TXA) is an antifibrinolytic agent commonly used to achieve hemostasis. However, there have been a few case reports suggesting that high-dose intravenous TXA has epileptogenic property. In patients with renal impairment, even administering the usual recommended dose of TXA can induce seizure episodes. We present here a patient on hemodialysis who developed seizures after receiving two doses of TXA over 5 h period. Wolters Kluwer Medknow Publications 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/73846/1/Selected%20organs%20of%20marine%20mussels%20as%20accurate%20biomonitors%20of%20metal%20bioavailability%20and%20contamination%20in%20the%20coastal%20waters%20challenges.pdf Fuah, Kar Wah and Lim, Christopher Thiam Seong and Pang, Daniel C. L. and Jin, Shyan Wong (2018) Seizure induced by tranexamic acid in a patient with chronic kidney disease on maintenance dialysis. Saudi Journal of Kidney Diseases and Transplantation, 29 (1). 207 - 209. ISSN 1319-2442 10.4103/1319-2442.225177 |
| spellingShingle | Fuah, Kar Wah Lim, Christopher Thiam Seong Pang, Daniel C. L. Jin, Shyan Wong Seizure induced by tranexamic acid in a patient with chronic kidney disease on maintenance dialysis |
| title | Seizure induced by tranexamic acid in a patient with chronic kidney disease on maintenance dialysis |
| title_full | Seizure induced by tranexamic acid in a patient with chronic kidney disease on maintenance dialysis |
| title_fullStr | Seizure induced by tranexamic acid in a patient with chronic kidney disease on maintenance dialysis |
| title_full_unstemmed | Seizure induced by tranexamic acid in a patient with chronic kidney disease on maintenance dialysis |
| title_short | Seizure induced by tranexamic acid in a patient with chronic kidney disease on maintenance dialysis |
| title_sort | seizure induced by tranexamic acid in a patient with chronic kidney disease on maintenance dialysis |
| url | http://psasir.upm.edu.my/id/eprint/73846/ http://psasir.upm.edu.my/id/eprint/73846/ http://psasir.upm.edu.my/id/eprint/73846/1/Selected%20organs%20of%20marine%20mussels%20as%20accurate%20biomonitors%20of%20metal%20bioavailability%20and%20contamination%20in%20the%20coastal%20waters%20challenges.pdf |