Risk analysis characterization of benzene and demographic factors toward immunoglobulin A
Background: Research on risk assessment at industrial sites has experienced growth during the end of this year. But in Indonesia, there is still limited research on risk assessment, especially regarding the importance of measuring non-carcinogenic risk assessment in the workplace. Benzene exposure i...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Scientific Foundation SPIROSKI
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/73809/ http://psasir.upm.edu.my/id/eprint/73809/1/BENZENE.pdf |
| _version_ | 1848857366078947328 |
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| author | Tualeka, Abdul Rohim Jalaludin, Juliana Salesman, Frans Wahyu, Atjo Tukiran, Tukiran Setiawan, Sabar Wibrata, Dwi Ananto Hasyim, Herlina Novita |
| author_facet | Tualeka, Abdul Rohim Jalaludin, Juliana Salesman, Frans Wahyu, Atjo Tukiran, Tukiran Setiawan, Sabar Wibrata, Dwi Ananto Hasyim, Herlina Novita |
| author_sort | Tualeka, Abdul Rohim |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: Research on risk assessment at industrial sites has experienced growth during the end of this year. But in Indonesia, there is still limited research on risk assessment, especially regarding the importance of measuring non-carcinogenic risk assessment in the workplace. Benzene exposure is believed to reduce levels of immunoglobulin A (IgA) in workers. AIM: The purpose of this study was to analyse the relationship between risk quotient (RQ) of non-carcinogenic risk assessment of benzene and demographic factors on IgA levels. Material and methods: The subjects of the study were shoe craftsmen who were at risk of benzene exposure. The study design was cross-sectional with a total population of 20 workers. Measurement of IgA levels by Immunoturbidimetric Assay with a normal standard of 2-3 mg/ml. Calculation of non-carcinogenic (RQ) risk characteristics with a comparison between risk agent non-carcinogenic intake with RfD or RfC benzene. Resuts: The majority of the study subjects aged over 45 years and had a working period of ≥ 25 years. There were 2 location points that had a threshold value exceeding the benzene standard (> 0.05 ppm), and 40% of the subjects had decreased IgA levels. Age and working periods had a significant relationship to IgA levels (p = 0.027; p = 0.047), while benzene and RQ levels did not have a significant relationship with IgA levels (p = 0.179; p = 0.436). Conclusion: Increasing age and working period can reduce IgA levels in the body. Further research is needed on risk assessment, especially on the safe limits of benzene concentration in the workplace to find out how long benzene exposure forms a non-carcinogenic or carcinogenic risk in workers’ bodies exposed to benzene. |
| first_indexed | 2025-11-15T11:56:24Z |
| format | Article |
| id | upm-73809 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:56:24Z |
| publishDate | 2018 |
| publisher | Scientific Foundation SPIROSKI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-738092021-07-15T21:32:26Z http://psasir.upm.edu.my/id/eprint/73809/ Risk analysis characterization of benzene and demographic factors toward immunoglobulin A Tualeka, Abdul Rohim Jalaludin, Juliana Salesman, Frans Wahyu, Atjo Tukiran, Tukiran Setiawan, Sabar Wibrata, Dwi Ananto Hasyim, Herlina Novita Background: Research on risk assessment at industrial sites has experienced growth during the end of this year. But in Indonesia, there is still limited research on risk assessment, especially regarding the importance of measuring non-carcinogenic risk assessment in the workplace. Benzene exposure is believed to reduce levels of immunoglobulin A (IgA) in workers. AIM: The purpose of this study was to analyse the relationship between risk quotient (RQ) of non-carcinogenic risk assessment of benzene and demographic factors on IgA levels. Material and methods: The subjects of the study were shoe craftsmen who were at risk of benzene exposure. The study design was cross-sectional with a total population of 20 workers. Measurement of IgA levels by Immunoturbidimetric Assay with a normal standard of 2-3 mg/ml. Calculation of non-carcinogenic (RQ) risk characteristics with a comparison between risk agent non-carcinogenic intake with RfD or RfC benzene. Resuts: The majority of the study subjects aged over 45 years and had a working period of ≥ 25 years. There were 2 location points that had a threshold value exceeding the benzene standard (> 0.05 ppm), and 40% of the subjects had decreased IgA levels. Age and working periods had a significant relationship to IgA levels (p = 0.027; p = 0.047), while benzene and RQ levels did not have a significant relationship with IgA levels (p = 0.179; p = 0.436). Conclusion: Increasing age and working period can reduce IgA levels in the body. Further research is needed on risk assessment, especially on the safe limits of benzene concentration in the workplace to find out how long benzene exposure forms a non-carcinogenic or carcinogenic risk in workers’ bodies exposed to benzene. Scientific Foundation SPIROSKI 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/73809/1/BENZENE.pdf Tualeka, Abdul Rohim and Jalaludin, Juliana and Salesman, Frans and Wahyu, Atjo and Tukiran, Tukiran and Setiawan, Sabar and Wibrata, Dwi Ananto and Hasyim, Herlina Novita (2018) Risk analysis characterization of benzene and demographic factors toward immunoglobulin A. Open Access Macedonian Journal of Medical Sciences, 6 (12). 2381 - 2385. ISSN 1857-9655 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311471/ 10.3889/oamjms.2018.488 |
| spellingShingle | Tualeka, Abdul Rohim Jalaludin, Juliana Salesman, Frans Wahyu, Atjo Tukiran, Tukiran Setiawan, Sabar Wibrata, Dwi Ananto Hasyim, Herlina Novita Risk analysis characterization of benzene and demographic factors toward immunoglobulin A |
| title | Risk analysis characterization of benzene and demographic factors toward immunoglobulin A |
| title_full | Risk analysis characterization of benzene and demographic factors toward immunoglobulin A |
| title_fullStr | Risk analysis characterization of benzene and demographic factors toward immunoglobulin A |
| title_full_unstemmed | Risk analysis characterization of benzene and demographic factors toward immunoglobulin A |
| title_short | Risk analysis characterization of benzene and demographic factors toward immunoglobulin A |
| title_sort | risk analysis characterization of benzene and demographic factors toward immunoglobulin a |
| url | http://psasir.upm.edu.my/id/eprint/73809/ http://psasir.upm.edu.my/id/eprint/73809/ http://psasir.upm.edu.my/id/eprint/73809/ http://psasir.upm.edu.my/id/eprint/73809/1/BENZENE.pdf |