Redox-dependent conformational changes of a proximal [4Fe-4S] cluster in Hyb-type [NiFe]-hydrogenase to protect the active site from O2
Citrobacter sp. S-77 [NiFe]-hydrogenase harbors a standard [4Fe–4S] cluster proximal to the Ni–Fe active site. The presence of relocatable water molecules and a flexible aspartate enables the [4Fe–4S] to display redox-dependent conformational changes. These structural features are proposed to be the...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Royal Society of Chemistry
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/73727/ http://psasir.upm.edu.my/id/eprint/73727/1/Redox-dependent%20conformational%20changes%20of%20a%20proximal%20%5B4Fe-4S%5D%20cluster%20in%20Hyb-type%20%5BNiFe%5D-hydrogenase%20to%20protect%20the%20active%20site%20from%20O2.pdf |
| _version_ | 1848857347736207360 |
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| author | Muhd Noor, Noor Dina Matsuura, Hiroaki Nishikawa, Koji Tai, Hulin Hirota, Shun Kim, Jaehyun Kang, Jiyoung Tateno, Masaru Yoon, Ki-Seok Ogo, Seiji Kubota, Shintaro Shomura, Yasuhito Higuchi, Yoshiki |
| author_facet | Muhd Noor, Noor Dina Matsuura, Hiroaki Nishikawa, Koji Tai, Hulin Hirota, Shun Kim, Jaehyun Kang, Jiyoung Tateno, Masaru Yoon, Ki-Seok Ogo, Seiji Kubota, Shintaro Shomura, Yasuhito Higuchi, Yoshiki |
| author_sort | Muhd Noor, Noor Dina |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Citrobacter sp. S-77 [NiFe]-hydrogenase harbors a standard [4Fe–4S] cluster proximal to the Ni–Fe active site. The presence of relocatable water molecules and a flexible aspartate enables the [4Fe–4S] to display redox-dependent conformational changes. These structural features are proposed to be the key aspects that protect the active site from O2 attack. |
| first_indexed | 2025-11-15T11:56:07Z |
| format | Article |
| id | upm-73727 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:56:07Z |
| publishDate | 2018 |
| publisher | Royal Society of Chemistry |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-737272022-03-02T09:00:54Z http://psasir.upm.edu.my/id/eprint/73727/ Redox-dependent conformational changes of a proximal [4Fe-4S] cluster in Hyb-type [NiFe]-hydrogenase to protect the active site from O2 Muhd Noor, Noor Dina Matsuura, Hiroaki Nishikawa, Koji Tai, Hulin Hirota, Shun Kim, Jaehyun Kang, Jiyoung Tateno, Masaru Yoon, Ki-Seok Ogo, Seiji Kubota, Shintaro Shomura, Yasuhito Higuchi, Yoshiki Citrobacter sp. S-77 [NiFe]-hydrogenase harbors a standard [4Fe–4S] cluster proximal to the Ni–Fe active site. The presence of relocatable water molecules and a flexible aspartate enables the [4Fe–4S] to display redox-dependent conformational changes. These structural features are proposed to be the key aspects that protect the active site from O2 attack. Royal Society of Chemistry 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/73727/1/Redox-dependent%20conformational%20changes%20of%20a%20proximal%20%5B4Fe-4S%5D%20cluster%20in%20Hyb-type%20%5BNiFe%5D-hydrogenase%20to%20protect%20the%20active%20site%20from%20O2.pdf Muhd Noor, Noor Dina and Matsuura, Hiroaki and Nishikawa, Koji and Tai, Hulin and Hirota, Shun and Kim, Jaehyun and Kang, Jiyoung and Tateno, Masaru and Yoon, Ki-Seok and Ogo, Seiji and Kubota, Shintaro and Shomura, Yasuhito and Higuchi, Yoshiki (2018) Redox-dependent conformational changes of a proximal [4Fe-4S] cluster in Hyb-type [NiFe]-hydrogenase to protect the active site from O2. Chemical Communications, 54 (87). 12385 - 12388. ISSN 1359-7345; ESSN: 1364-548X https://pubs.rsc.org/en/content/articlelanding/2018/cc/c8cc06261g 10.1039/C8CC06261G |
| spellingShingle | Muhd Noor, Noor Dina Matsuura, Hiroaki Nishikawa, Koji Tai, Hulin Hirota, Shun Kim, Jaehyun Kang, Jiyoung Tateno, Masaru Yoon, Ki-Seok Ogo, Seiji Kubota, Shintaro Shomura, Yasuhito Higuchi, Yoshiki Redox-dependent conformational changes of a proximal [4Fe-4S] cluster in Hyb-type [NiFe]-hydrogenase to protect the active site from O2 |
| title | Redox-dependent conformational changes of a proximal [4Fe-4S] cluster in Hyb-type [NiFe]-hydrogenase to protect the active site from O2 |
| title_full | Redox-dependent conformational changes of a proximal [4Fe-4S] cluster in Hyb-type [NiFe]-hydrogenase to protect the active site from O2 |
| title_fullStr | Redox-dependent conformational changes of a proximal [4Fe-4S] cluster in Hyb-type [NiFe]-hydrogenase to protect the active site from O2 |
| title_full_unstemmed | Redox-dependent conformational changes of a proximal [4Fe-4S] cluster in Hyb-type [NiFe]-hydrogenase to protect the active site from O2 |
| title_short | Redox-dependent conformational changes of a proximal [4Fe-4S] cluster in Hyb-type [NiFe]-hydrogenase to protect the active site from O2 |
| title_sort | redox-dependent conformational changes of a proximal [4fe-4s] cluster in hyb-type [nife]-hydrogenase to protect the active site from o2 |
| url | http://psasir.upm.edu.my/id/eprint/73727/ http://psasir.upm.edu.my/id/eprint/73727/ http://psasir.upm.edu.my/id/eprint/73727/ http://psasir.upm.edu.my/id/eprint/73727/1/Redox-dependent%20conformational%20changes%20of%20a%20proximal%20%5B4Fe-4S%5D%20cluster%20in%20Hyb-type%20%5BNiFe%5D-hydrogenase%20to%20protect%20the%20active%20site%20from%20O2.pdf |