Clinical utility of plasma fructosamine concentration as a hypoglycemic biomarker during early lactation in dairy cattle
Background: Plasma fructosamine concentration ([FRA]) is a widely used long term hyperglycemic biomarker in humans and dogs, but its clinical usefulness as a hypoglycemic biomarker in dairy cattle is uncertain. Objectives: To evaluate the relationship between plasma [FRA] and glucose concentration (...
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| Format: | Article |
| Language: | English |
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Wiley-Blackwell
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/73423/ http://psasir.upm.edu.my/id/eprint/73423/1/PROTEIN.pdf |
| _version_ | 1848857272966447104 |
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| author | Mark Hiew, Wen Han A. A., Megahed Constable, Peter D. |
| author_facet | Mark Hiew, Wen Han A. A., Megahed Constable, Peter D. |
| author_sort | Mark Hiew, Wen Han |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: Plasma fructosamine concentration ([FRA]) is a widely used long term hyperglycemic biomarker in humans and dogs, but its clinical usefulness as a hypoglycemic biomarker in dairy cattle is uncertain. Objectives: To evaluate the relationship between plasma [FRA] and glucose concentration ([gluc]) as well as indices of energy balance during early lactation in dairy cattle, and to characterize the influence of plasma total protein concentration ([TP]) and albumin concentration ([albumin]) on [FRA]. Animals: Convenience sample comprising 103 periparturient Holstein-Friesian cattle. Methods: Plasma [gluc], [TP], [albumin], and other clinicopathologic indices of energy status were determined periodically from Day 4 postpartum. Body condition score (BCS) was assessed, and backfat thickness (BFT) and longissimus dorsi muscle thickness (LDT) were measured ultrasonographically. Plasma [FRA] was measured at approximately 28 days postpartum. Associations between plasma [FRA] and study variables were evaluated using Spearman's rho and stepwise forward linear regression. statistical significance was declared at P < 0.05. Results: A positive association was detected between plasma [FRA] and mean plasma [gluc] from Days 4-28 postpartum (rs = +0.36, P < 0.001), and between plasma [FRA] and LDT (rs = +0.28, P = 0.007), BCS (rs = +0.23, P = 0.029), and BFT (rs = +0.21, P = 0.043). Multivariable regression identified a positive association between plasma [FRA] and mean plasma [gluc] and [albumin] from Days 4-28 postpartum. Correcting plasma [FRA] for [albumin] improved the association (rs = +0.46, P < 0.001) between plasma [FRA] and mean plasma [gluc]. Conclusions and clinical importance: Plasma [FRA] does not provide a clinically useful method for quantifying the magnitude of hypoglycemia or negative energy balance in dairy cows during early lactation. |
| first_indexed | 2025-11-15T11:54:55Z |
| format | Article |
| id | upm-73423 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:54:55Z |
| publishDate | 2018 |
| publisher | Wiley-Blackwell |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-734232020-11-10T07:28:08Z http://psasir.upm.edu.my/id/eprint/73423/ Clinical utility of plasma fructosamine concentration as a hypoglycemic biomarker during early lactation in dairy cattle Mark Hiew, Wen Han A. A., Megahed Constable, Peter D. Background: Plasma fructosamine concentration ([FRA]) is a widely used long term hyperglycemic biomarker in humans and dogs, but its clinical usefulness as a hypoglycemic biomarker in dairy cattle is uncertain. Objectives: To evaluate the relationship between plasma [FRA] and glucose concentration ([gluc]) as well as indices of energy balance during early lactation in dairy cattle, and to characterize the influence of plasma total protein concentration ([TP]) and albumin concentration ([albumin]) on [FRA]. Animals: Convenience sample comprising 103 periparturient Holstein-Friesian cattle. Methods: Plasma [gluc], [TP], [albumin], and other clinicopathologic indices of energy status were determined periodically from Day 4 postpartum. Body condition score (BCS) was assessed, and backfat thickness (BFT) and longissimus dorsi muscle thickness (LDT) were measured ultrasonographically. Plasma [FRA] was measured at approximately 28 days postpartum. Associations between plasma [FRA] and study variables were evaluated using Spearman's rho and stepwise forward linear regression. statistical significance was declared at P < 0.05. Results: A positive association was detected between plasma [FRA] and mean plasma [gluc] from Days 4-28 postpartum (rs = +0.36, P < 0.001), and between plasma [FRA] and LDT (rs = +0.28, P = 0.007), BCS (rs = +0.23, P = 0.029), and BFT (rs = +0.21, P = 0.043). Multivariable regression identified a positive association between plasma [FRA] and mean plasma [gluc] and [albumin] from Days 4-28 postpartum. Correcting plasma [FRA] for [albumin] improved the association (rs = +0.46, P < 0.001) between plasma [FRA] and mean plasma [gluc]. Conclusions and clinical importance: Plasma [FRA] does not provide a clinically useful method for quantifying the magnitude of hypoglycemia or negative energy balance in dairy cows during early lactation. Wiley-Blackwell 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/73423/1/PROTEIN.pdf Mark Hiew, Wen Han and A. A., Megahed and Constable, Peter D. (2018) Clinical utility of plasma fructosamine concentration as a hypoglycemic biomarker during early lactation in dairy cattle. Journal of Veterinary Internal Medicine, 32 (2). 846 - 852. ISSN 1939-1676; ESSN: 0891-6640 https://pubmed.ncbi.nlm.nih.gov/29424465/ 10.1111/jvim.15049 |
| spellingShingle | Mark Hiew, Wen Han A. A., Megahed Constable, Peter D. Clinical utility of plasma fructosamine concentration as a hypoglycemic biomarker during early lactation in dairy cattle |
| title | Clinical utility of plasma fructosamine concentration as a hypoglycemic biomarker during early lactation in dairy cattle |
| title_full | Clinical utility of plasma fructosamine concentration as a hypoglycemic biomarker during early lactation in dairy cattle |
| title_fullStr | Clinical utility of plasma fructosamine concentration as a hypoglycemic biomarker during early lactation in dairy cattle |
| title_full_unstemmed | Clinical utility of plasma fructosamine concentration as a hypoglycemic biomarker during early lactation in dairy cattle |
| title_short | Clinical utility of plasma fructosamine concentration as a hypoglycemic biomarker during early lactation in dairy cattle |
| title_sort | clinical utility of plasma fructosamine concentration as a hypoglycemic biomarker during early lactation in dairy cattle |
| url | http://psasir.upm.edu.my/id/eprint/73423/ http://psasir.upm.edu.my/id/eprint/73423/ http://psasir.upm.edu.my/id/eprint/73423/ http://psasir.upm.edu.my/id/eprint/73423/1/PROTEIN.pdf |