Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies
A variety of imine derivatives have been synthesized via Suzuki cross coupling of N-(4-bromophenyl)-1-(3-bromothiophen-2-yl)methanimine with various arylboronic acids in moderate to good yields (58–72%). A wide range of electron donating and withdrawing functional groups were well tolerated in react...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/72707/ http://psasir.upm.edu.my/id/eprint/72707/1/Facile%20synthesis.pdf |
| _version_ | 1848857183914033152 |
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| author | Rizwan, Komal Rasool, Nasir Rehman, Ravya Mahmood, Tariq Ayub, Khurshid Rasheed, Tahir Ahmad, Gulraiz Malik, Ayesha Khan, Shakeel Ahmad Akhtar, Muhammad Nadeem Mohammed Alitheen, Noorjahan Banu Aziz, Muhammad Nazirul Mubin |
| author_facet | Rizwan, Komal Rasool, Nasir Rehman, Ravya Mahmood, Tariq Ayub, Khurshid Rasheed, Tahir Ahmad, Gulraiz Malik, Ayesha Khan, Shakeel Ahmad Akhtar, Muhammad Nadeem Mohammed Alitheen, Noorjahan Banu Aziz, Muhammad Nazirul Mubin |
| author_sort | Rizwan, Komal |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | A variety of imine derivatives have been synthesized via Suzuki cross coupling of N-(4-bromophenyl)-1-(3-bromothiophen-2-yl)methanimine with various arylboronic acids in moderate to good yields (58–72%). A wide range of electron donating and withdrawing functional groups were well tolerated in reaction conditions. To explore the structural properties, Density functional theory (DFT) investigations on all synthesized molecules (3a–3i) were performed. Conceptual DFT reactivity descriptors and molecular electrostatic potential analyses were performed by using B3LYP/6-31G(d,p) method to explore the reactivity and reacting sites of all derivatives (3a–3i). |
| first_indexed | 2025-11-15T11:53:30Z |
| format | Article |
| id | upm-72707 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:53:30Z |
| publishDate | 2018 |
| publisher | SpringerOpen |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-727072021-01-27T15:35:20Z http://psasir.upm.edu.my/id/eprint/72707/ Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies Rizwan, Komal Rasool, Nasir Rehman, Ravya Mahmood, Tariq Ayub, Khurshid Rasheed, Tahir Ahmad, Gulraiz Malik, Ayesha Khan, Shakeel Ahmad Akhtar, Muhammad Nadeem Mohammed Alitheen, Noorjahan Banu Aziz, Muhammad Nazirul Mubin A variety of imine derivatives have been synthesized via Suzuki cross coupling of N-(4-bromophenyl)-1-(3-bromothiophen-2-yl)methanimine with various arylboronic acids in moderate to good yields (58–72%). A wide range of electron donating and withdrawing functional groups were well tolerated in reaction conditions. To explore the structural properties, Density functional theory (DFT) investigations on all synthesized molecules (3a–3i) were performed. Conceptual DFT reactivity descriptors and molecular electrostatic potential analyses were performed by using B3LYP/6-31G(d,p) method to explore the reactivity and reacting sites of all derivatives (3a–3i). SpringerOpen 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72707/1/Facile%20synthesis.pdf Rizwan, Komal and Rasool, Nasir and Rehman, Ravya and Mahmood, Tariq and Ayub, Khurshid and Rasheed, Tahir and Ahmad, Gulraiz and Malik, Ayesha and Khan, Shakeel Ahmad and Akhtar, Muhammad Nadeem and Mohammed Alitheen, Noorjahan Banu and Aziz, Muhammad Nazirul Mubin (2018) Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies. Chemistry Central Journal, 12 (1). art. no. 84. pp. 1-9. ISSN 1752-153X https://link.springer.com/article/10.1186/s13065-018-0451-0 10.1186/s13065-018-0451-0 |
| spellingShingle | Rizwan, Komal Rasool, Nasir Rehman, Ravya Mahmood, Tariq Ayub, Khurshid Rasheed, Tahir Ahmad, Gulraiz Malik, Ayesha Khan, Shakeel Ahmad Akhtar, Muhammad Nadeem Mohammed Alitheen, Noorjahan Banu Aziz, Muhammad Nazirul Mubin Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies |
| title | Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies |
| title_full | Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies |
| title_fullStr | Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies |
| title_full_unstemmed | Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies |
| title_short | Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies |
| title_sort | facile synthesis of n- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via suzuki cross-coupling reaction: their characterization and dft studies |
| url | http://psasir.upm.edu.my/id/eprint/72707/ http://psasir.upm.edu.my/id/eprint/72707/ http://psasir.upm.edu.my/id/eprint/72707/ http://psasir.upm.edu.my/id/eprint/72707/1/Facile%20synthesis.pdf |