Fabrication, characterization and cytotoxicity of spherical-shaped conjugated gold-cockle shell derived calcium carbonate nanoparticles for biomedical applications
The evolution of nanomaterial in science has brought about a growing increase in nanotechnology, biomedicine, and engineering fields. This study was aimed at fabrication and characterization of conjugated gold-cockle shell-derived calcium carbonate nanoparticles (Au-CSCaCO3NPs) for biomedical applic...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/72702/ http://psasir.upm.edu.my/id/eprint/72702/1/Fabrication.pdf |
| _version_ | 1848857183036375040 |
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| author | Kiranda, Hanan Karimah Mahmud, Rozi Abubakar, Danmaigoro Abu Bakar @ Zakaria, Md Zuki |
| author_facet | Kiranda, Hanan Karimah Mahmud, Rozi Abubakar, Danmaigoro Abu Bakar @ Zakaria, Md Zuki |
| author_sort | Kiranda, Hanan Karimah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The evolution of nanomaterial in science has brought about a growing increase in nanotechnology, biomedicine, and engineering fields. This study was aimed at fabrication and characterization of conjugated gold-cockle shell-derived calcium carbonate nanoparticles (Au-CSCaCO3NPs) for biomedical application. The synthetic technique employed used gold nanoparticle citrate reduction method and a simple precipitation method coupled with mechanical use of a Programmable roller-ball mill. The synthesized conjugated nanomaterial was characterized for its physicochemical properties using transmission electron microscope (TEM), field emission scanning electron microscope (FESEM) equipped with energy dispersive X-ray (EDX) and Fourier transform infrared spectroscopy (FTIR). However, the intricacy of cellular mechanisms can prove challenging for nanomaterial like Au-CSCaCO3NPs and thus, the need for cytotoxicity assessment. The obtained spherical-shaped nanoparticles (light-green purplish) have an average diameter size of 35 ± 16 nm, high carbon and oxygen composition. The conjugated nanomaterial, also possesses a unique spectra for aragonite polymorph and carboxylic bond significantly supporting interactions between conjugated nanoparticles. The negative surface charge and spectra absorbance highlighted their stability. The resultant spherical shaped conjugated Au-CSCaCO3NPs could be a great nanomaterial for biomedical applications. |
| first_indexed | 2025-11-15T11:53:30Z |
| format | Article |
| id | upm-72702 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:53:30Z |
| publishDate | 2018 |
| publisher | SpringerOpen |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-727022021-01-11T09:19:10Z http://psasir.upm.edu.my/id/eprint/72702/ Fabrication, characterization and cytotoxicity of spherical-shaped conjugated gold-cockle shell derived calcium carbonate nanoparticles for biomedical applications Kiranda, Hanan Karimah Mahmud, Rozi Abubakar, Danmaigoro Abu Bakar @ Zakaria, Md Zuki The evolution of nanomaterial in science has brought about a growing increase in nanotechnology, biomedicine, and engineering fields. This study was aimed at fabrication and characterization of conjugated gold-cockle shell-derived calcium carbonate nanoparticles (Au-CSCaCO3NPs) for biomedical application. The synthetic technique employed used gold nanoparticle citrate reduction method and a simple precipitation method coupled with mechanical use of a Programmable roller-ball mill. The synthesized conjugated nanomaterial was characterized for its physicochemical properties using transmission electron microscope (TEM), field emission scanning electron microscope (FESEM) equipped with energy dispersive X-ray (EDX) and Fourier transform infrared spectroscopy (FTIR). However, the intricacy of cellular mechanisms can prove challenging for nanomaterial like Au-CSCaCO3NPs and thus, the need for cytotoxicity assessment. The obtained spherical-shaped nanoparticles (light-green purplish) have an average diameter size of 35 ± 16 nm, high carbon and oxygen composition. The conjugated nanomaterial, also possesses a unique spectra for aragonite polymorph and carboxylic bond significantly supporting interactions between conjugated nanoparticles. The negative surface charge and spectra absorbance highlighted their stability. The resultant spherical shaped conjugated Au-CSCaCO3NPs could be a great nanomaterial for biomedical applications. SpringerOpen 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72702/1/Fabrication.pdf Kiranda, Hanan Karimah and Mahmud, Rozi and Abubakar, Danmaigoro and Abu Bakar @ Zakaria, Md Zuki (2018) Fabrication, characterization and cytotoxicity of spherical-shaped conjugated gold-cockle shell derived calcium carbonate nanoparticles for biomedical applications. Nanoscale Research Letters, 13 (1). pp. 1-10. ISSN 1556-276X https://nanoscalereslett.springeropen.com/articles/10.1186/s11671-017-2411-3 10.1186/s11671-017-2411-3 |
| spellingShingle | Kiranda, Hanan Karimah Mahmud, Rozi Abubakar, Danmaigoro Abu Bakar @ Zakaria, Md Zuki Fabrication, characterization and cytotoxicity of spherical-shaped conjugated gold-cockle shell derived calcium carbonate nanoparticles for biomedical applications |
| title | Fabrication, characterization and cytotoxicity of spherical-shaped conjugated gold-cockle shell derived calcium carbonate nanoparticles for biomedical applications |
| title_full | Fabrication, characterization and cytotoxicity of spherical-shaped conjugated gold-cockle shell derived calcium carbonate nanoparticles for biomedical applications |
| title_fullStr | Fabrication, characterization and cytotoxicity of spherical-shaped conjugated gold-cockle shell derived calcium carbonate nanoparticles for biomedical applications |
| title_full_unstemmed | Fabrication, characterization and cytotoxicity of spherical-shaped conjugated gold-cockle shell derived calcium carbonate nanoparticles for biomedical applications |
| title_short | Fabrication, characterization and cytotoxicity of spherical-shaped conjugated gold-cockle shell derived calcium carbonate nanoparticles for biomedical applications |
| title_sort | fabrication, characterization and cytotoxicity of spherical-shaped conjugated gold-cockle shell derived calcium carbonate nanoparticles for biomedical applications |
| url | http://psasir.upm.edu.my/id/eprint/72702/ http://psasir.upm.edu.my/id/eprint/72702/ http://psasir.upm.edu.my/id/eprint/72702/ http://psasir.upm.edu.my/id/eprint/72702/1/Fabrication.pdf |