Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences
To determine the effect of DENV (serotype 2) repeated infections on lung cells is the main goal of this study. From the result, lung histology of control BALB/c mice showed normal alveolar morphology, while vehicle control BALB/c mice highlighted a slight thickening of the alveolar septum. Lung hist...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor and Francis
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/72600/ http://psasir.upm.edu.my/id/eprint/72600/1/Repeated%20infections%20of%20dengue%20.pdf |
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| author | Syed Saudi, Siti Noor Sakinah Kumaran, Sharmilah Kumari Munisvaradass, Rusheni Mok, Pooi Ling Chee, Hui Yee Seenichamy, Arivudainambi Vijayaraman, Kiruthiga P. Higuchi, Akon Rajan, Mariappan Seenivasan, K. Nataraja Marlina Arulselvan, Palanisamy Benelli, Giovanni Subbiah, Suresh Kumar |
| author_facet | Syed Saudi, Siti Noor Sakinah Kumaran, Sharmilah Kumari Munisvaradass, Rusheni Mok, Pooi Ling Chee, Hui Yee Seenichamy, Arivudainambi Vijayaraman, Kiruthiga P. Higuchi, Akon Rajan, Mariappan Seenivasan, K. Nataraja Marlina Arulselvan, Palanisamy Benelli, Giovanni Subbiah, Suresh Kumar |
| author_sort | Syed Saudi, Siti Noor Sakinah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | To determine the effect of DENV (serotype 2) repeated infections on lung cells is the main goal of this study. From the result, lung histology of control BALB/c mice showed normal alveolar morphology, while vehicle control BALB/c mice highlighted a slight thickening of the alveolar septum. Lung histopathology of BALB/c mice infected twice by DENV-2 showed the presence of hemorrhage, plasma leakage and presence of hemosiderin-laden macrophages (HLMs). Notably, in the lung of BALB/c mice infected four times by DENV-2, we observed thickening and disruption of the alveolar septum, inflammatory cell infiltration, plasma leakage and increased cellularity. Megakaryocyte releasing platelets were also found into the lung alveolus. Overall, our findings showed severe histopathological damage in lungs repeatedly infected by DENV-2, allowing us to argue that they can be linked to pulmonary complication. Result also showed that the number of infections with similar total DENV-2 titer led to different histopathological changes. |
| first_indexed | 2025-11-15T11:53:06Z |
| format | Article |
| id | upm-72600 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:53:06Z |
| publishDate | 2018 |
| publisher | Taylor and Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-726002020-11-09T09:37:08Z http://psasir.upm.edu.my/id/eprint/72600/ Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences Syed Saudi, Siti Noor Sakinah Kumaran, Sharmilah Kumari Munisvaradass, Rusheni Mok, Pooi Ling Chee, Hui Yee Seenichamy, Arivudainambi Vijayaraman, Kiruthiga P. Higuchi, Akon Rajan, Mariappan Seenivasan, K. Nataraja Marlina Arulselvan, Palanisamy Benelli, Giovanni Subbiah, Suresh Kumar To determine the effect of DENV (serotype 2) repeated infections on lung cells is the main goal of this study. From the result, lung histology of control BALB/c mice showed normal alveolar morphology, while vehicle control BALB/c mice highlighted a slight thickening of the alveolar septum. Lung histopathology of BALB/c mice infected twice by DENV-2 showed the presence of hemorrhage, plasma leakage and presence of hemosiderin-laden macrophages (HLMs). Notably, in the lung of BALB/c mice infected four times by DENV-2, we observed thickening and disruption of the alveolar septum, inflammatory cell infiltration, plasma leakage and increased cellularity. Megakaryocyte releasing platelets were also found into the lung alveolus. Overall, our findings showed severe histopathological damage in lungs repeatedly infected by DENV-2, allowing us to argue that they can be linked to pulmonary complication. Result also showed that the number of infections with similar total DENV-2 titer led to different histopathological changes. Taylor and Francis 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72600/1/Repeated%20infections%20of%20dengue%20.pdf Syed Saudi, Siti Noor Sakinah and Kumaran, Sharmilah Kumari and Munisvaradass, Rusheni and Mok, Pooi Ling and Chee, Hui Yee and Seenichamy, Arivudainambi and Vijayaraman, Kiruthiga P. and Higuchi, Akon and Rajan, Mariappan and Seenivasan, K. Nataraja and Marlina and Arulselvan, Palanisamy and Benelli, Giovanni and Subbiah, Suresh Kumar (2018) Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences. Pathogens and Global Health, 112 (5). 259 - 267. ISSN 2047-7724; ESSN: 2047-7732 https://www.tandfonline.com/doi/abs/10.1080/20477724.2018.1492765 10.1080/20477724.2018.1492765 |
| spellingShingle | Syed Saudi, Siti Noor Sakinah Kumaran, Sharmilah Kumari Munisvaradass, Rusheni Mok, Pooi Ling Chee, Hui Yee Seenichamy, Arivudainambi Vijayaraman, Kiruthiga P. Higuchi, Akon Rajan, Mariappan Seenivasan, K. Nataraja Marlina Arulselvan, Palanisamy Benelli, Giovanni Subbiah, Suresh Kumar Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences |
| title | Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences |
| title_full | Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences |
| title_fullStr | Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences |
| title_full_unstemmed | Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences |
| title_short | Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences |
| title_sort | repeated infections of dengue (serotype denv-2) in lung cells of balb/c mice lead to severe histopathological consequences |
| url | http://psasir.upm.edu.my/id/eprint/72600/ http://psasir.upm.edu.my/id/eprint/72600/ http://psasir.upm.edu.my/id/eprint/72600/ http://psasir.upm.edu.my/id/eprint/72600/1/Repeated%20infections%20of%20dengue%20.pdf |