Efficacy of nutritional interventions on inflammatory markers in haemodialysis patients: a systematic review and limited meta-analysis
Low-grade chronic inflammation is prevalent in patients undergoing haemodialysis (HD) treatment and is linked to the development of premature atherosclerosis and mortality. The non-pharmacological approach to treat inflammation in HD patients through nutritional intervention is well cited. We aimed...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/72531/ http://psasir.upm.edu.my/id/eprint/72531/1/Efficacy%20of%20nutritional%20interventions%20.pdf |
| _version_ | 1848857140785053696 |
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| author | Khor, Ban Hock Narayanan, Sreelakshmi Sankara Sahathevan, Sharmela Abdul Gafor, Abdul Halim Mat Daud, Zulfitri 'Azuan Khosla, Pramod Sabatino, Alice Fiaccadori, Enrico Chinna, Karuthan Karupaiah, Tilakavati |
| author_facet | Khor, Ban Hock Narayanan, Sreelakshmi Sankara Sahathevan, Sharmela Abdul Gafor, Abdul Halim Mat Daud, Zulfitri 'Azuan Khosla, Pramod Sabatino, Alice Fiaccadori, Enrico Chinna, Karuthan Karupaiah, Tilakavati |
| author_sort | Khor, Ban Hock |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Low-grade chronic inflammation is prevalent in patients undergoing haemodialysis (HD) treatment and is linked to the development of premature atherosclerosis and mortality. The non-pharmacological approach to treat inflammation in HD patients through nutritional intervention is well cited. We aimed to assess the efficacy of different nutritional interventions at improving inflammatory outcomes in HD patients, based on markers such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumour necrosis factor-α (TNF-α). We searched PubMed, Cochrane Library, and Embase for randomized controlled trials (RCT) published before June 2017. Inclusion criteria included RCTs on adult patients on maintenance HD treatment with duration of nutritional interventions for a minimum 4 weeks. Risk of bias was assessed using the Jadad score. In total, 46 RCTs experimenting different nutritional interventions were included in the review and categorized into polyphenols rich foods, omega-3 fatty acids, antioxidants, vitamin D, fibres, and probiotics. Meta-analyses indicated significant reduction in CRP levels by omega-3 fatty acids (Random model effect: −0.667 mg/L, p < 0.001) and vitamin E (fixed model effect: −0.257 mg/L, p = 0.005). Evidence for other groups of nutritional interventions was inconclusive. In conclusion, our meta-analysis provided evidence that omega-3 fatty acids and vitamin E could improve inflammatory outcomes in HD patients. |
| first_indexed | 2025-11-15T11:52:49Z |
| format | Article |
| id | upm-72531 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:52:49Z |
| publishDate | 2018 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-725312020-10-22T03:23:07Z http://psasir.upm.edu.my/id/eprint/72531/ Efficacy of nutritional interventions on inflammatory markers in haemodialysis patients: a systematic review and limited meta-analysis Khor, Ban Hock Narayanan, Sreelakshmi Sankara Sahathevan, Sharmela Abdul Gafor, Abdul Halim Mat Daud, Zulfitri 'Azuan Khosla, Pramod Sabatino, Alice Fiaccadori, Enrico Chinna, Karuthan Karupaiah, Tilakavati Low-grade chronic inflammation is prevalent in patients undergoing haemodialysis (HD) treatment and is linked to the development of premature atherosclerosis and mortality. The non-pharmacological approach to treat inflammation in HD patients through nutritional intervention is well cited. We aimed to assess the efficacy of different nutritional interventions at improving inflammatory outcomes in HD patients, based on markers such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumour necrosis factor-α (TNF-α). We searched PubMed, Cochrane Library, and Embase for randomized controlled trials (RCT) published before June 2017. Inclusion criteria included RCTs on adult patients on maintenance HD treatment with duration of nutritional interventions for a minimum 4 weeks. Risk of bias was assessed using the Jadad score. In total, 46 RCTs experimenting different nutritional interventions were included in the review and categorized into polyphenols rich foods, omega-3 fatty acids, antioxidants, vitamin D, fibres, and probiotics. Meta-analyses indicated significant reduction in CRP levels by omega-3 fatty acids (Random model effect: −0.667 mg/L, p < 0.001) and vitamin E (fixed model effect: −0.257 mg/L, p = 0.005). Evidence for other groups of nutritional interventions was inconclusive. In conclusion, our meta-analysis provided evidence that omega-3 fatty acids and vitamin E could improve inflammatory outcomes in HD patients. MDPI 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72531/1/Efficacy%20of%20nutritional%20interventions%20.pdf Khor, Ban Hock and Narayanan, Sreelakshmi Sankara and Sahathevan, Sharmela and Abdul Gafor, Abdul Halim and Mat Daud, Zulfitri 'Azuan and Khosla, Pramod and Sabatino, Alice and Fiaccadori, Enrico and Chinna, Karuthan and Karupaiah, Tilakavati (2018) Efficacy of nutritional interventions on inflammatory markers in haemodialysis patients: a systematic review and limited meta-analysis. Nutrients, 10 (4). pp. 1-19. ISSN 2072-6643 https://www.mdpi.com/2072-6643/10/4/397 10.3390/nu10040397 |
| spellingShingle | Khor, Ban Hock Narayanan, Sreelakshmi Sankara Sahathevan, Sharmela Abdul Gafor, Abdul Halim Mat Daud, Zulfitri 'Azuan Khosla, Pramod Sabatino, Alice Fiaccadori, Enrico Chinna, Karuthan Karupaiah, Tilakavati Efficacy of nutritional interventions on inflammatory markers in haemodialysis patients: a systematic review and limited meta-analysis |
| title | Efficacy of nutritional interventions on inflammatory markers in haemodialysis patients: a systematic review and limited meta-analysis |
| title_full | Efficacy of nutritional interventions on inflammatory markers in haemodialysis patients: a systematic review and limited meta-analysis |
| title_fullStr | Efficacy of nutritional interventions on inflammatory markers in haemodialysis patients: a systematic review and limited meta-analysis |
| title_full_unstemmed | Efficacy of nutritional interventions on inflammatory markers in haemodialysis patients: a systematic review and limited meta-analysis |
| title_short | Efficacy of nutritional interventions on inflammatory markers in haemodialysis patients: a systematic review and limited meta-analysis |
| title_sort | efficacy of nutritional interventions on inflammatory markers in haemodialysis patients: a systematic review and limited meta-analysis |
| url | http://psasir.upm.edu.my/id/eprint/72531/ http://psasir.upm.edu.my/id/eprint/72531/ http://psasir.upm.edu.my/id/eprint/72531/ http://psasir.upm.edu.my/id/eprint/72531/1/Efficacy%20of%20nutritional%20interventions%20.pdf |