Effect of virgin avocado oil on diet‐induced hypercholesterolemia in rats via 1H NMR‐based metabolomics approach
Hypercholesterolemia is a major risk factor for the initiation and development of nonalcoholic fatty liver disease and atherosclerosis. The present study evaluated the hypocholesterolemic effect of virgin avocado oil (VAO) using urinary metabolomic method. Male Sprague–Dawley rats were fed high‐chol...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/72464/ http://psasir.upm.edu.my/id/eprint/72464/1/Effect%20of%20virgin%20avocado%20oil%20on%20diet.pdf |
| _version_ | 1848857125225234432 |
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| author | Tan, Chin Xuan Chong, Gun Hean Hamzah, Hazilawati Mohd Ghazali, Hasanah |
| author_facet | Tan, Chin Xuan Chong, Gun Hean Hamzah, Hazilawati Mohd Ghazali, Hasanah |
| author_sort | Tan, Chin Xuan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Hypercholesterolemia is a major risk factor for the initiation and development of nonalcoholic fatty liver disease and atherosclerosis. The present study evaluated the hypocholesterolemic effect of virgin avocado oil (VAO) using urinary metabolomic method. Male Sprague–Dawley rats were fed high‐cholesterol diet for four weeks to induce hypercholesterolemia. After confirming the establishment of hypercholesterolemia model, the VAO (450 and 900 mg·kg−1·day−1) and simvastatin (10 mg·kg−1·day−1) were given orally while maintaining the high‐cholesterol diet for another four weeks. Assessment of urinary metabolomics using NMR revealed that VAO treatment could partially recover the metabolism dysfunction induced by hypercholesterolemia mainly via lipid, energy, amino acid, and gut microbiota metabolism. |
| first_indexed | 2025-11-15T11:52:34Z |
| format | Article |
| id | upm-72464 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:52:34Z |
| publishDate | 2018 |
| publisher | Wiley |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-724642020-06-16T07:23:30Z http://psasir.upm.edu.my/id/eprint/72464/ Effect of virgin avocado oil on diet‐induced hypercholesterolemia in rats via 1H NMR‐based metabolomics approach Tan, Chin Xuan Chong, Gun Hean Hamzah, Hazilawati Mohd Ghazali, Hasanah Hypercholesterolemia is a major risk factor for the initiation and development of nonalcoholic fatty liver disease and atherosclerosis. The present study evaluated the hypocholesterolemic effect of virgin avocado oil (VAO) using urinary metabolomic method. Male Sprague–Dawley rats were fed high‐cholesterol diet for four weeks to induce hypercholesterolemia. After confirming the establishment of hypercholesterolemia model, the VAO (450 and 900 mg·kg−1·day−1) and simvastatin (10 mg·kg−1·day−1) were given orally while maintaining the high‐cholesterol diet for another four weeks. Assessment of urinary metabolomics using NMR revealed that VAO treatment could partially recover the metabolism dysfunction induced by hypercholesterolemia mainly via lipid, energy, amino acid, and gut microbiota metabolism. Wiley 2018-11 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72464/1/Effect%20of%20virgin%20avocado%20oil%20on%20diet.pdf Tan, Chin Xuan and Chong, Gun Hean and Hamzah, Hazilawati and Mohd Ghazali, Hasanah (2018) Effect of virgin avocado oil on diet‐induced hypercholesterolemia in rats via 1H NMR‐based metabolomics approach. Phytotherapy Research, 32 (11). 2264 - 2274. ISSN 0951-418X; ESSN: 1099-1573 https://onlinelibrary.wiley.com/doi/full/10.1002/ptr.6164 10.1002/ptr.6164 |
| spellingShingle | Tan, Chin Xuan Chong, Gun Hean Hamzah, Hazilawati Mohd Ghazali, Hasanah Effect of virgin avocado oil on diet‐induced hypercholesterolemia in rats via 1H NMR‐based metabolomics approach |
| title | Effect of virgin avocado oil on diet‐induced hypercholesterolemia in rats via 1H NMR‐based metabolomics approach |
| title_full | Effect of virgin avocado oil on diet‐induced hypercholesterolemia in rats via 1H NMR‐based metabolomics approach |
| title_fullStr | Effect of virgin avocado oil on diet‐induced hypercholesterolemia in rats via 1H NMR‐based metabolomics approach |
| title_full_unstemmed | Effect of virgin avocado oil on diet‐induced hypercholesterolemia in rats via 1H NMR‐based metabolomics approach |
| title_short | Effect of virgin avocado oil on diet‐induced hypercholesterolemia in rats via 1H NMR‐based metabolomics approach |
| title_sort | effect of virgin avocado oil on diet‐induced hypercholesterolemia in rats via 1h nmr‐based metabolomics approach |
| url | http://psasir.upm.edu.my/id/eprint/72464/ http://psasir.upm.edu.my/id/eprint/72464/ http://psasir.upm.edu.my/id/eprint/72464/ http://psasir.upm.edu.my/id/eprint/72464/1/Effect%20of%20virgin%20avocado%20oil%20on%20diet.pdf |