Drug release and kinetic study of tamoxifen citrate conjugated with magnetite nanoparticle for drug delivery application
Breast cancer is affecting about 23 % of all cancers diagnosed in women. So, it is crucial to develop the treatment for breast cancer patient. Tamoxifen (TAM) has been used for treating estrogen receptor (ER)-positive breast cancer however TAM suffer from non-specific delivery to the breast cancer....
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Integrated Publishing Association
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/72339/ http://psasir.upm.edu.my/id/eprint/72339/1/Drug%20release%20and%20kinetic%20study%20of%20tamoxifen%20citrate%20conjugated%20with%20magnetite%20nanoparticle%20for%20drug%20delivery%20application%20.pdf |
| _version_ | 1848857093654708224 |
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| author | Albert, Emmellie Laura Shirosaki, Yuki Che Abdullah, Che Azurahanim |
| author_facet | Albert, Emmellie Laura Shirosaki, Yuki Che Abdullah, Che Azurahanim |
| author_sort | Albert, Emmellie Laura |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Breast cancer is affecting about 23 % of all cancers diagnosed in women. So, it is crucial to develop the treatment for breast cancer patient. Tamoxifen (TAM) has been used for treating estrogen receptor (ER)-positive breast cancer however TAM suffer from non-specific delivery to the breast cancer. TAM was introduce to magnetite nanoparticle (MNP) to increase tissue selectivity using Poly (d,l-lactice-co-glycolide acid) (PLGA-TAM-OAMNP) via oil in water emulsion and evaporation process. It was discovered that the size of the modified nanoparticle is 384 ± 17 nm while also maintaining its superparamagnetic nature. The percentage of drug loading and entrapment efficiency of TAM inside the PLGA-TAMOAMNP is around 6% and 80% respectively. Then, drug release was conducted for the next 96 hours releasing about 90% of the drug. The in vitro drug release was due to autocatalysis of PLGA. |
| first_indexed | 2025-11-15T11:52:04Z |
| format | Article |
| id | upm-72339 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:52:04Z |
| publishDate | 2018 |
| publisher | Integrated Publishing Association |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-723392020-05-08T04:12:03Z http://psasir.upm.edu.my/id/eprint/72339/ Drug release and kinetic study of tamoxifen citrate conjugated with magnetite nanoparticle for drug delivery application Albert, Emmellie Laura Shirosaki, Yuki Che Abdullah, Che Azurahanim Breast cancer is affecting about 23 % of all cancers diagnosed in women. So, it is crucial to develop the treatment for breast cancer patient. Tamoxifen (TAM) has been used for treating estrogen receptor (ER)-positive breast cancer however TAM suffer from non-specific delivery to the breast cancer. TAM was introduce to magnetite nanoparticle (MNP) to increase tissue selectivity using Poly (d,l-lactice-co-glycolide acid) (PLGA-TAM-OAMNP) via oil in water emulsion and evaporation process. It was discovered that the size of the modified nanoparticle is 384 ± 17 nm while also maintaining its superparamagnetic nature. The percentage of drug loading and entrapment efficiency of TAM inside the PLGA-TAMOAMNP is around 6% and 80% respectively. Then, drug release was conducted for the next 96 hours releasing about 90% of the drug. The in vitro drug release was due to autocatalysis of PLGA. Integrated Publishing Association 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72339/1/Drug%20release%20and%20kinetic%20study%20of%20tamoxifen%20citrate%20conjugated%20with%20magnetite%20nanoparticle%20for%20drug%20delivery%20application%20.pdf Albert, Emmellie Laura and Shirosaki, Yuki and Che Abdullah, Che Azurahanim (2018) Drug release and kinetic study of tamoxifen citrate conjugated with magnetite nanoparticle for drug delivery application. International Journal of Applied Engineering Research, 13 (7). 5360 - 5369. ISSN 0976-4259 https://www.ripublication.com/Volume/ijaerv13n7.htm |
| spellingShingle | Albert, Emmellie Laura Shirosaki, Yuki Che Abdullah, Che Azurahanim Drug release and kinetic study of tamoxifen citrate conjugated with magnetite nanoparticle for drug delivery application |
| title | Drug release and kinetic study of tamoxifen citrate conjugated with magnetite nanoparticle for drug delivery application |
| title_full | Drug release and kinetic study of tamoxifen citrate conjugated with magnetite nanoparticle for drug delivery application |
| title_fullStr | Drug release and kinetic study of tamoxifen citrate conjugated with magnetite nanoparticle for drug delivery application |
| title_full_unstemmed | Drug release and kinetic study of tamoxifen citrate conjugated with magnetite nanoparticle for drug delivery application |
| title_short | Drug release and kinetic study of tamoxifen citrate conjugated with magnetite nanoparticle for drug delivery application |
| title_sort | drug release and kinetic study of tamoxifen citrate conjugated with magnetite nanoparticle for drug delivery application |
| url | http://psasir.upm.edu.my/id/eprint/72339/ http://psasir.upm.edu.my/id/eprint/72339/ http://psasir.upm.edu.my/id/eprint/72339/1/Drug%20release%20and%20kinetic%20study%20of%20tamoxifen%20citrate%20conjugated%20with%20magnetite%20nanoparticle%20for%20drug%20delivery%20application%20.pdf |