Dietary acid load, IGF-1 single nucleotide polymorphism and bone resorption among postmenopausal Chinese women
The interaction of dietary and genetic factors may affect the development of bone deterioration. This study investigated whether the effects of dietary acid load (DAL) on bone loss in postmenopausal Chinese women were moderated by the insulin-like growth factor-1 (IGF-1) single nucleotide polymorphi...
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| Format: | Article |
| Language: | English |
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MDPI
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/72287/ http://psasir.upm.edu.my/id/eprint/72287/1/Dietary%20acid%20load.pdf |
| _version_ | 1848857082728546304 |
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| author | Lim, Sook Yee Mohd Shariff, Zalilah Chin, Yit Siew Vasudevan, Ramachandran Chan, Yoke Mun |
| author_facet | Lim, Sook Yee Mohd Shariff, Zalilah Chin, Yit Siew Vasudevan, Ramachandran Chan, Yoke Mun |
| author_sort | Lim, Sook Yee |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The interaction of dietary and genetic factors may affect the development of bone deterioration. This study investigated whether the effects of dietary acid load (DAL) on bone loss in postmenopausal Chinese women were moderated by the insulin-like growth factor-1 (IGF-1) single nucleotide polymorphism, a known gene that plays a role in the regulation of bone formation and bone remodeling. A total of 217 healthy participants were recruited from the National Council of Senior Citizens Organizations Malaysia. Serum collagen type 1 cross-linked C-telopeptide was used as a surrogate bone marker to assess bone resorption and Agena® MassARRAY genotyping analysis was used to identify the signaling of IGF-1 rs35767. The dietary acid load was measured by potential renal acid load score while physical activity was ascertained using the Global Physical Activity Questionnaire. Hierarchical regression was applied to test the main and interaction effects of DAL and IGF-1 genotypes in bone resorption. The result supported the diet-dependent acid-base balance theory that higher DAL was positively associated with bone resorption (β = 0.152, p = 0.031, F(6,207) = 2.11, sig-F = 0.036, R2 = 0.079). However, the results indicated that there was no significant correlation between IGF-1 and bone resorption, or any significant interaction between DAL and IGF-1. In conclusion, there was no moderating effect of IGF-1 on the relationship between DAL and bone resorption. |
| first_indexed | 2025-11-15T11:51:54Z |
| format | Article |
| id | upm-72287 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:51:54Z |
| publishDate | 2018 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-722872020-05-02T04:52:10Z http://psasir.upm.edu.my/id/eprint/72287/ Dietary acid load, IGF-1 single nucleotide polymorphism and bone resorption among postmenopausal Chinese women Lim, Sook Yee Mohd Shariff, Zalilah Chin, Yit Siew Vasudevan, Ramachandran Chan, Yoke Mun The interaction of dietary and genetic factors may affect the development of bone deterioration. This study investigated whether the effects of dietary acid load (DAL) on bone loss in postmenopausal Chinese women were moderated by the insulin-like growth factor-1 (IGF-1) single nucleotide polymorphism, a known gene that plays a role in the regulation of bone formation and bone remodeling. A total of 217 healthy participants were recruited from the National Council of Senior Citizens Organizations Malaysia. Serum collagen type 1 cross-linked C-telopeptide was used as a surrogate bone marker to assess bone resorption and Agena® MassARRAY genotyping analysis was used to identify the signaling of IGF-1 rs35767. The dietary acid load was measured by potential renal acid load score while physical activity was ascertained using the Global Physical Activity Questionnaire. Hierarchical regression was applied to test the main and interaction effects of DAL and IGF-1 genotypes in bone resorption. The result supported the diet-dependent acid-base balance theory that higher DAL was positively associated with bone resorption (β = 0.152, p = 0.031, F(6,207) = 2.11, sig-F = 0.036, R2 = 0.079). However, the results indicated that there was no significant correlation between IGF-1 and bone resorption, or any significant interaction between DAL and IGF-1. In conclusion, there was no moderating effect of IGF-1 on the relationship between DAL and bone resorption. MDPI 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72287/1/Dietary%20acid%20load.pdf Lim, Sook Yee and Mohd Shariff, Zalilah and Chin, Yit Siew and Vasudevan, Ramachandran and Chan, Yoke Mun (2018) Dietary acid load, IGF-1 single nucleotide polymorphism and bone resorption among postmenopausal Chinese women. Nutrients, 10 (7). pp. 1-13. ISSN 2072-6643; ESSN: 2072-6643 https://www.mdpi.com/2072-6643/10/7/915 10.3390/nu10070915 |
| spellingShingle | Lim, Sook Yee Mohd Shariff, Zalilah Chin, Yit Siew Vasudevan, Ramachandran Chan, Yoke Mun Dietary acid load, IGF-1 single nucleotide polymorphism and bone resorption among postmenopausal Chinese women |
| title | Dietary acid load, IGF-1 single nucleotide polymorphism and bone resorption among postmenopausal Chinese women |
| title_full | Dietary acid load, IGF-1 single nucleotide polymorphism and bone resorption among postmenopausal Chinese women |
| title_fullStr | Dietary acid load, IGF-1 single nucleotide polymorphism and bone resorption among postmenopausal Chinese women |
| title_full_unstemmed | Dietary acid load, IGF-1 single nucleotide polymorphism and bone resorption among postmenopausal Chinese women |
| title_short | Dietary acid load, IGF-1 single nucleotide polymorphism and bone resorption among postmenopausal Chinese women |
| title_sort | dietary acid load, igf-1 single nucleotide polymorphism and bone resorption among postmenopausal chinese women |
| url | http://psasir.upm.edu.my/id/eprint/72287/ http://psasir.upm.edu.my/id/eprint/72287/ http://psasir.upm.edu.my/id/eprint/72287/ http://psasir.upm.edu.my/id/eprint/72287/1/Dietary%20acid%20load.pdf |