Development of de novo diabetes in long-term follow-up after bariatric surgery
Introduction: While bariatric surgery leads to significant prevention and improvement of type 2 diabetes, patients may rarely develop diabetes after bariatric surgery. The aim of this study was to determine the incidence and the characteristic of new-onset diabetes after bariatric surgery over a 17-...
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| Format: | Article |
| Language: | English |
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Springer Verlag
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/72257/ http://psasir.upm.edu.my/id/eprint/72257/1/Development%20of%20de%20novo%20diabetes.pdf |
| _version_ | 1848857075125321728 |
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| author | Nor Hanipah, Zubaidah Punchai, Suriya Brethauer, Stacy A. Schauer, Philip R. Aminian, Ali |
| author_facet | Nor Hanipah, Zubaidah Punchai, Suriya Brethauer, Stacy A. Schauer, Philip R. Aminian, Ali |
| author_sort | Nor Hanipah, Zubaidah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: While bariatric surgery leads to significant prevention and improvement of type 2 diabetes, patients may rarely develop diabetes after bariatric surgery. The aim of this study was to determine the incidence and the characteristic of new-onset diabetes after bariatric surgery over a 17-year period at our institution. Methods: Non-diabetic patients who underwent bariatric surgery at a single academic center (1997–2013) and had a postoperative glycated hemoglobin (HbA1c) ≥ 6.5%, fasting blood glucose (FBG) ≥ 126 mg/dl, or positive glucose tolerance test were identified and studied. Results: Out of 2263 non-diabetic patients at the time of bariatric surgery, 11 patients had new-onset diabetes in the median follow-up time of 9 years (interquartile range [IQR], 4–12). Bariatric procedures performed were Roux-en-Y gastric bypass (n = 7), adjustable gastric banding (n = 3), and sleeve gastrectomy (n = 1). The median interval between surgery and diagnosis of diabetes was 6 years (IQR, 2–9). At the last follow-up, the median HbA1c and FBG values were 6.3% (IQR, 6.1–6.5) and 95 mg/dl (IQR, 85–122), respectively. Possible etiologic factors leading to diabetes were weight regain to baseline (n = 6, 55%), steroid-induced after renal transplantation (n = 1), pancreatic insufficiency after pancreatitis (n = 1), and unknown (n = 3). Conclusion: De novo diabetes after bariatric surgery is rare with an incidence of 0.4% based on our cohort. Weight regain was common (> 50%) in patients who developed new-onset diabetes suggesting recurrent severe obesity as a potential etiologic factor. All patients had good glycemic control (HbA1c ≤ 7%) in the long-term postoperative follow-up. |
| first_indexed | 2025-11-15T11:51:47Z |
| format | Article |
| id | upm-72257 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:51:47Z |
| publishDate | 2018 |
| publisher | Springer Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-722572020-04-26T15:46:49Z http://psasir.upm.edu.my/id/eprint/72257/ Development of de novo diabetes in long-term follow-up after bariatric surgery Nor Hanipah, Zubaidah Punchai, Suriya Brethauer, Stacy A. Schauer, Philip R. Aminian, Ali Introduction: While bariatric surgery leads to significant prevention and improvement of type 2 diabetes, patients may rarely develop diabetes after bariatric surgery. The aim of this study was to determine the incidence and the characteristic of new-onset diabetes after bariatric surgery over a 17-year period at our institution. Methods: Non-diabetic patients who underwent bariatric surgery at a single academic center (1997–2013) and had a postoperative glycated hemoglobin (HbA1c) ≥ 6.5%, fasting blood glucose (FBG) ≥ 126 mg/dl, or positive glucose tolerance test were identified and studied. Results: Out of 2263 non-diabetic patients at the time of bariatric surgery, 11 patients had new-onset diabetes in the median follow-up time of 9 years (interquartile range [IQR], 4–12). Bariatric procedures performed were Roux-en-Y gastric bypass (n = 7), adjustable gastric banding (n = 3), and sleeve gastrectomy (n = 1). The median interval between surgery and diagnosis of diabetes was 6 years (IQR, 2–9). At the last follow-up, the median HbA1c and FBG values were 6.3% (IQR, 6.1–6.5) and 95 mg/dl (IQR, 85–122), respectively. Possible etiologic factors leading to diabetes were weight regain to baseline (n = 6, 55%), steroid-induced after renal transplantation (n = 1), pancreatic insufficiency after pancreatitis (n = 1), and unknown (n = 3). Conclusion: De novo diabetes after bariatric surgery is rare with an incidence of 0.4% based on our cohort. Weight regain was common (> 50%) in patients who developed new-onset diabetes suggesting recurrent severe obesity as a potential etiologic factor. All patients had good glycemic control (HbA1c ≤ 7%) in the long-term postoperative follow-up. Springer Verlag 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72257/1/Development%20of%20de%20novo%20diabetes.pdf Nor Hanipah, Zubaidah and Punchai, Suriya and Brethauer, Stacy A. and Schauer, Philip R. and Aminian, Ali (2018) Development of de novo diabetes in long-term follow-up after bariatric surgery. Obesity Surgery, 28 (8). 2247 - 2251. ISSN 0960-8923, ESSN: 1708-0428 https://link.springer.com/article/10.1007/s11695-018-3194-z#citeas 10.1007/s11695-018-3194-z |
| spellingShingle | Nor Hanipah, Zubaidah Punchai, Suriya Brethauer, Stacy A. Schauer, Philip R. Aminian, Ali Development of de novo diabetes in long-term follow-up after bariatric surgery |
| title | Development of de novo diabetes in long-term follow-up after bariatric surgery |
| title_full | Development of de novo diabetes in long-term follow-up after bariatric surgery |
| title_fullStr | Development of de novo diabetes in long-term follow-up after bariatric surgery |
| title_full_unstemmed | Development of de novo diabetes in long-term follow-up after bariatric surgery |
| title_short | Development of de novo diabetes in long-term follow-up after bariatric surgery |
| title_sort | development of de novo diabetes in long-term follow-up after bariatric surgery |
| url | http://psasir.upm.edu.my/id/eprint/72257/ http://psasir.upm.edu.my/id/eprint/72257/ http://psasir.upm.edu.my/id/eprint/72257/ http://psasir.upm.edu.my/id/eprint/72257/1/Development%20of%20de%20novo%20diabetes.pdf |