Designing of the anticancer nanocomposite with sustained release properties by using graphene oxide nanocarrier with Phenethyl isothiocyanate as anticancer agent
In this study anticancer nanocomposite was designed using graphene oxide (GO) as nanocarrier and Phenethyl isothiocyanate (PEITC) as anticancer agent. The designed formulation was characterized in detailed with XRD, Raman, UV/Vis, FTIR, DLS and TEM etc. The designed anticancer nanocomposite showed m...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Multidisciplinary Digital Publishing Institute
2018
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/72200/ http://psasir.upm.edu.my/id/eprint/72200/1/Designing%20of%20the%20anticancer%20nanocomposite%20.pdf |
| _version_ | 1848857063853129728 |
|---|---|
| author | Seema, Dasan Mary Jaya Bullo, Saifullah Selvanayagam, Mariadoss Gothai, Sivapragasam Hussein, Mohd Zobir Subbiah, Suresh Kumar Mohd Esa, Norhaizan Arulselvan, Palanisamy |
| author_facet | Seema, Dasan Mary Jaya Bullo, Saifullah Selvanayagam, Mariadoss Gothai, Sivapragasam Hussein, Mohd Zobir Subbiah, Suresh Kumar Mohd Esa, Norhaizan Arulselvan, Palanisamy |
| author_sort | Seema, Dasan Mary Jaya |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | In this study anticancer nanocomposite was designed using graphene oxide (GO) as nanocarrier and Phenethyl isothiocyanate (PEITC) as anticancer agent. The designed formulation was characterized in detailed with XRD, Raman, UV/Vis, FTIR, DLS and TEM etc. The designed anticancer nanocomposite showed much better anticancer activity against liver cancer HepG2 cells compared to the free drug PEITC and was also found to be nontoxic to the normal 3T3 cells. In vitro release of the drug from the anticancer nanocomposite formulation was found to be sustained in human body simulated phosphate buffer saline (PBS) solution of pH 7.4 (blood pH) and pH 4.8 (intracellular lysosomal pH). This study suggests that GO could be developed as an efficient drug carrier to conjugate with PEITC for pharmaceutical applications in cancer chemotherapies. |
| first_indexed | 2025-11-15T11:51:36Z |
| format | Article |
| id | upm-72200 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:51:36Z |
| publishDate | 2018 |
| publisher | Multidisciplinary Digital Publishing Institute |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-722002022-07-01T08:21:35Z http://psasir.upm.edu.my/id/eprint/72200/ Designing of the anticancer nanocomposite with sustained release properties by using graphene oxide nanocarrier with Phenethyl isothiocyanate as anticancer agent Seema, Dasan Mary Jaya Bullo, Saifullah Selvanayagam, Mariadoss Gothai, Sivapragasam Hussein, Mohd Zobir Subbiah, Suresh Kumar Mohd Esa, Norhaizan Arulselvan, Palanisamy In this study anticancer nanocomposite was designed using graphene oxide (GO) as nanocarrier and Phenethyl isothiocyanate (PEITC) as anticancer agent. The designed formulation was characterized in detailed with XRD, Raman, UV/Vis, FTIR, DLS and TEM etc. The designed anticancer nanocomposite showed much better anticancer activity against liver cancer HepG2 cells compared to the free drug PEITC and was also found to be nontoxic to the normal 3T3 cells. In vitro release of the drug from the anticancer nanocomposite formulation was found to be sustained in human body simulated phosphate buffer saline (PBS) solution of pH 7.4 (blood pH) and pH 4.8 (intracellular lysosomal pH). This study suggests that GO could be developed as an efficient drug carrier to conjugate with PEITC for pharmaceutical applications in cancer chemotherapies. Multidisciplinary Digital Publishing Institute 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72200/1/Designing%20of%20the%20anticancer%20nanocomposite%20.pdf Seema, Dasan Mary Jaya and Bullo, Saifullah and Selvanayagam, Mariadoss and Gothai, Sivapragasam and Hussein, Mohd Zobir and Subbiah, Suresh Kumar and Mohd Esa, Norhaizan and Arulselvan, Palanisamy (2018) Designing of the anticancer nanocomposite with sustained release properties by using graphene oxide nanocarrier with Phenethyl isothiocyanate as anticancer agent. Pharmaceutics, 10 (3). 1-Dec. ISSN 1999-4923 https://www.mdpi.com/1999-4923/10/3/109 10.3390/pharmaceutics10030109 |
| spellingShingle | Seema, Dasan Mary Jaya Bullo, Saifullah Selvanayagam, Mariadoss Gothai, Sivapragasam Hussein, Mohd Zobir Subbiah, Suresh Kumar Mohd Esa, Norhaizan Arulselvan, Palanisamy Designing of the anticancer nanocomposite with sustained release properties by using graphene oxide nanocarrier with Phenethyl isothiocyanate as anticancer agent |
| title | Designing of the anticancer nanocomposite with sustained release properties by using graphene oxide nanocarrier with Phenethyl isothiocyanate as anticancer agent |
| title_full | Designing of the anticancer nanocomposite with sustained release properties by using graphene oxide nanocarrier with Phenethyl isothiocyanate as anticancer agent |
| title_fullStr | Designing of the anticancer nanocomposite with sustained release properties by using graphene oxide nanocarrier with Phenethyl isothiocyanate as anticancer agent |
| title_full_unstemmed | Designing of the anticancer nanocomposite with sustained release properties by using graphene oxide nanocarrier with Phenethyl isothiocyanate as anticancer agent |
| title_short | Designing of the anticancer nanocomposite with sustained release properties by using graphene oxide nanocarrier with Phenethyl isothiocyanate as anticancer agent |
| title_sort | designing of the anticancer nanocomposite with sustained release properties by using graphene oxide nanocarrier with phenethyl isothiocyanate as anticancer agent |
| url | http://psasir.upm.edu.my/id/eprint/72200/ http://psasir.upm.edu.my/id/eprint/72200/ http://psasir.upm.edu.my/id/eprint/72200/ http://psasir.upm.edu.my/id/eprint/72200/1/Designing%20of%20the%20anticancer%20nanocomposite%20.pdf |