Cytotoxicity effect of Aaptamine and its derivatives on Acanthamoeba castellanii (IMR isolate)
Acanthamoeba is a free-living amoebae that is ubiquitously present in various natural environments. In this study, several of Aaptamine derivatives (2-5) were synthesized and evaluated for their cytotoxicity effect against Acanthamoeba castellanii (IMR isolate). The Acanthamoeba viability was determ...
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| Format: | Article |
| Language: | English |
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Publications International
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/72164/ http://psasir.upm.edu.my/id/eprint/72164/1/Cytotoxicity%20effect%20of%20Aaptamine%20and%20its%20derivatives%20on%20Acanthamoeba%20castellanii.pdf |
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| author | Mat Amin, Nakisah Hamdin, Muhammad Shafiq Azarnudin, Muhd Amir Taufiq Asari, Asnuzilawati Abdul Rashid, Fatin Nur Ain Mohd Nor, Siti Mariam |
| author_facet | Mat Amin, Nakisah Hamdin, Muhammad Shafiq Azarnudin, Muhd Amir Taufiq Asari, Asnuzilawati Abdul Rashid, Fatin Nur Ain Mohd Nor, Siti Mariam |
| author_sort | Mat Amin, Nakisah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Acanthamoeba is a free-living amoebae that is ubiquitously present in various natural environments. In this study, several of Aaptamine derivatives (2-5) were synthesized and evaluated for their cytotoxicity effect against Acanthamoeba castellanii (IMR isolate). The Acanthamoeba viability was determine using range of concentration from 0 until 50 µg/mL for each compounds. The treatment was done for 72 hours and Eosin stainning was used to determine the cell viability. From the result obtained, Aaptamine (1) and its derivatives (2-5) have significant effect toward inhibition growth on Acanthamoeba with of 1,4-dibenzylaaptamine (5) was observed as the most potent compound as anti-amoeba agent. |
| first_indexed | 2025-11-15T11:51:27Z |
| format | Article |
| id | upm-72164 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:51:27Z |
| publishDate | 2018 |
| publisher | Publications International |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-721642020-03-05T03:22:46Z http://psasir.upm.edu.my/id/eprint/72164/ Cytotoxicity effect of Aaptamine and its derivatives on Acanthamoeba castellanii (IMR isolate) Mat Amin, Nakisah Hamdin, Muhammad Shafiq Azarnudin, Muhd Amir Taufiq Asari, Asnuzilawati Abdul Rashid, Fatin Nur Ain Mohd Nor, Siti Mariam Acanthamoeba is a free-living amoebae that is ubiquitously present in various natural environments. In this study, several of Aaptamine derivatives (2-5) were synthesized and evaluated for their cytotoxicity effect against Acanthamoeba castellanii (IMR isolate). The Acanthamoeba viability was determine using range of concentration from 0 until 50 µg/mL for each compounds. The treatment was done for 72 hours and Eosin stainning was used to determine the cell viability. From the result obtained, Aaptamine (1) and its derivatives (2-5) have significant effect toward inhibition growth on Acanthamoeba with of 1,4-dibenzylaaptamine (5) was observed as the most potent compound as anti-amoeba agent. Publications International 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72164/1/Cytotoxicity%20effect%20of%20Aaptamine%20and%20its%20derivatives%20on%20Acanthamoeba%20castellanii.pdf Mat Amin, Nakisah and Hamdin, Muhammad Shafiq and Azarnudin, Muhd Amir Taufiq and Asari, Asnuzilawati and Abdul Rashid, Fatin Nur Ain and Mohd Nor, Siti Mariam (2018) Cytotoxicity effect of Aaptamine and its derivatives on Acanthamoeba castellanii (IMR isolate). Science International, 30 (2). 309 - 301. ISSN 1013-5316 http://www.sci-int.com/Search?catid=98 |
| spellingShingle | Mat Amin, Nakisah Hamdin, Muhammad Shafiq Azarnudin, Muhd Amir Taufiq Asari, Asnuzilawati Abdul Rashid, Fatin Nur Ain Mohd Nor, Siti Mariam Cytotoxicity effect of Aaptamine and its derivatives on Acanthamoeba castellanii (IMR isolate) |
| title | Cytotoxicity effect of Aaptamine and its derivatives on Acanthamoeba castellanii (IMR isolate) |
| title_full | Cytotoxicity effect of Aaptamine and its derivatives on Acanthamoeba castellanii (IMR isolate) |
| title_fullStr | Cytotoxicity effect of Aaptamine and its derivatives on Acanthamoeba castellanii (IMR isolate) |
| title_full_unstemmed | Cytotoxicity effect of Aaptamine and its derivatives on Acanthamoeba castellanii (IMR isolate) |
| title_short | Cytotoxicity effect of Aaptamine and its derivatives on Acanthamoeba castellanii (IMR isolate) |
| title_sort | cytotoxicity effect of aaptamine and its derivatives on acanthamoeba castellanii (imr isolate) |
| url | http://psasir.upm.edu.my/id/eprint/72164/ http://psasir.upm.edu.my/id/eprint/72164/ http://psasir.upm.edu.my/id/eprint/72164/1/Cytotoxicity%20effect%20of%20Aaptamine%20and%20its%20derivatives%20on%20Acanthamoeba%20castellanii.pdf |