Critical roles of IL-33/ST2 pathway in neurological disorders
Interleukin-33 (IL-33) is an IL-1 family member, which exhibits both pro- and anti-inflammatory properties solely based on the type of the disease itself. Generally, IL-33 is expressed by both endothelial and epithelial cells and mediates its function based on the interaction with various receptors,...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/72141/ http://psasir.upm.edu.my/id/eprint/72141/1/neurological%20disorders.pdf |
| _version_ | 1848857048551260160 |
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| author | Abd Rachman Isnadi, Mohammad Faruq Chin, Voon Kin Abd. Majid, Roslaini Lee, Tze Yan Abdullah, Maizaton Atmadini Omenesa, Ramatu Bello Ibraheem, Zaid Osamah Basir, Rusliza |
| author_facet | Abd Rachman Isnadi, Mohammad Faruq Chin, Voon Kin Abd. Majid, Roslaini Lee, Tze Yan Abdullah, Maizaton Atmadini Omenesa, Ramatu Bello Ibraheem, Zaid Osamah Basir, Rusliza |
| author_sort | Abd Rachman Isnadi, Mohammad Faruq |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Interleukin-33 (IL-33) is an IL-1 family member, which exhibits both pro- and anti-inflammatory properties solely based on the type of the disease itself. Generally, IL-33 is expressed by both endothelial and epithelial cells and mediates its function based on the interaction with various receptors, mainly with ST2 variants. IL-33 is a potent inducer for the Th2 immune response which includes defence mechanism in brain diseases. Thus, in this paper, we review the biological features of IL-33 and the critical roles of IL-33/ST2 pathway in selected neurological disorders including Alzheimer’s disease, multiple sclerosis, and malaria infection to discuss the involvement of IL-33/ST2 pathway during these brain diseases and its potential as future immunotherapeutic agents or for intervention purposes. |
| first_indexed | 2025-11-15T11:51:21Z |
| format | Article |
| id | upm-72141 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:51:21Z |
| publishDate | 2018 |
| publisher | Hindawi |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-721412020-03-04T04:03:11Z http://psasir.upm.edu.my/id/eprint/72141/ Critical roles of IL-33/ST2 pathway in neurological disorders Abd Rachman Isnadi, Mohammad Faruq Chin, Voon Kin Abd. Majid, Roslaini Lee, Tze Yan Abdullah, Maizaton Atmadini Omenesa, Ramatu Bello Ibraheem, Zaid Osamah Basir, Rusliza Interleukin-33 (IL-33) is an IL-1 family member, which exhibits both pro- and anti-inflammatory properties solely based on the type of the disease itself. Generally, IL-33 is expressed by both endothelial and epithelial cells and mediates its function based on the interaction with various receptors, mainly with ST2 variants. IL-33 is a potent inducer for the Th2 immune response which includes defence mechanism in brain diseases. Thus, in this paper, we review the biological features of IL-33 and the critical roles of IL-33/ST2 pathway in selected neurological disorders including Alzheimer’s disease, multiple sclerosis, and malaria infection to discuss the involvement of IL-33/ST2 pathway during these brain diseases and its potential as future immunotherapeutic agents or for intervention purposes. Hindawi 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/72141/1/neurological%20disorders.pdf Abd Rachman Isnadi, Mohammad Faruq and Chin, Voon Kin and Abd. Majid, Roslaini and Lee, Tze Yan and Abdullah, Maizaton Atmadini and Omenesa, Ramatu Bello and Ibraheem, Zaid Osamah and Basir, Rusliza (2018) Critical roles of IL-33/ST2 pathway in neurological disorders. Mediators of Inflammation, 2018. art. no. 5346413. pp. 1-9. ISSN 0962-9351; ESSN: 1466-1861 https://www.hindawi.com/journals/mi/2018/5346413/ 10.1155/2018/5346413 |
| spellingShingle | Abd Rachman Isnadi, Mohammad Faruq Chin, Voon Kin Abd. Majid, Roslaini Lee, Tze Yan Abdullah, Maizaton Atmadini Omenesa, Ramatu Bello Ibraheem, Zaid Osamah Basir, Rusliza Critical roles of IL-33/ST2 pathway in neurological disorders |
| title | Critical roles of IL-33/ST2 pathway in neurological disorders |
| title_full | Critical roles of IL-33/ST2 pathway in neurological disorders |
| title_fullStr | Critical roles of IL-33/ST2 pathway in neurological disorders |
| title_full_unstemmed | Critical roles of IL-33/ST2 pathway in neurological disorders |
| title_short | Critical roles of IL-33/ST2 pathway in neurological disorders |
| title_sort | critical roles of il-33/st2 pathway in neurological disorders |
| url | http://psasir.upm.edu.my/id/eprint/72141/ http://psasir.upm.edu.my/id/eprint/72141/ http://psasir.upm.edu.my/id/eprint/72141/ http://psasir.upm.edu.my/id/eprint/72141/1/neurological%20disorders.pdf |