Preparations of Betulinic Acid Derivatives
Betulinic acid, 3~hydroxy-lup20(29)-ene-28-oic acid is a pentacyclic triterpene. Esterification reactions of betulinic acid were investigated. Betulinic acid esters such as 3-0-succinyl-betulinic acid, 3-0-(2',2'-dimethylsucciny1)-betulinic acid, 3-0-(3',3'-dimethylsucciny1)-b...
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| Format: | Thesis |
| Language: | English English |
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2004
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| Online Access: | http://psasir.upm.edu.my/id/eprint/7080/ http://psasir.upm.edu.my/id/eprint/7080/1/FSAS_2004_5%28a%29.pdf |
| _version_ | 1848840497124081664 |
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| author | Mohd Ali, Mohd Tajudin |
| author_facet | Mohd Ali, Mohd Tajudin |
| author_sort | Mohd Ali, Mohd Tajudin |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Betulinic acid, 3~hydroxy-lup20(29)-ene-28-oic acid is a pentacyclic triterpene.
Esterification reactions of betulinic acid were investigated. Betulinic acid
esters such as 3-0-succinyl-betulinic acid, 3-0-(2',2'-dimethylsucciny1)-betulinic
acid, 3-0-(3',3'-dimethylsucciny1)-betulinic acid and 3-0-glutaryl-betulinic acid
were prepared. Their structures were determined by spectroscopic methods.
Optimization studies on the esterification reactions were carried out for
betulinic acid with succinic anhydride and with 2',2'-dimethylsuccinic acid
only. The effects of varying parameters such as the mole ratio, temperature, time
course and mole of catalyst were investigated.
Generally, the optimal conditions for preparing 3-0-succinyl-betulinic acid was
obtained by mixing betulinic acid with succinic anhydride in a 1:8 ratio and
refluxing in 0.124 mole of pyridine for 24 hours at a temperature of 115°C ; the
optimal conditions for the preparation of 3-0-(2',2'-dimethylsucciny1)-betulinic acid was obtained by refluxing betulinic acid and Zf,2'-dimethylsuccinic acid in
a 1:6 ratio with the presence of 0.124 mole of pyridine for 24 hours at a
temperature of 85°C. The percentage conversions as detected by gas
chromatography analysis were 53.5 and 56.2%, respectively. |
| first_indexed | 2025-11-15T07:28:17Z |
| format | Thesis |
| id | upm-7080 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T07:28:17Z |
| publishDate | 2004 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-70802023-11-21T08:23:00Z http://psasir.upm.edu.my/id/eprint/7080/ Preparations of Betulinic Acid Derivatives Mohd Ali, Mohd Tajudin Betulinic acid, 3~hydroxy-lup20(29)-ene-28-oic acid is a pentacyclic triterpene. Esterification reactions of betulinic acid were investigated. Betulinic acid esters such as 3-0-succinyl-betulinic acid, 3-0-(2',2'-dimethylsucciny1)-betulinic acid, 3-0-(3',3'-dimethylsucciny1)-betulinic acid and 3-0-glutaryl-betulinic acid were prepared. Their structures were determined by spectroscopic methods. Optimization studies on the esterification reactions were carried out for betulinic acid with succinic anhydride and with 2',2'-dimethylsuccinic acid only. The effects of varying parameters such as the mole ratio, temperature, time course and mole of catalyst were investigated. Generally, the optimal conditions for preparing 3-0-succinyl-betulinic acid was obtained by mixing betulinic acid with succinic anhydride in a 1:8 ratio and refluxing in 0.124 mole of pyridine for 24 hours at a temperature of 115°C ; the optimal conditions for the preparation of 3-0-(2',2'-dimethylsucciny1)-betulinic acid was obtained by refluxing betulinic acid and Zf,2'-dimethylsuccinic acid in a 1:6 ratio with the presence of 0.124 mole of pyridine for 24 hours at a temperature of 85°C. The percentage conversions as detected by gas chromatography analysis were 53.5 and 56.2%, respectively. 2004 Thesis NonPeerReviewed text en http://psasir.upm.edu.my/id/eprint/7080/1/FSAS_2004_5%28a%29.pdf Mohd Ali, Mohd Tajudin (2004) Preparations of Betulinic Acid Derivatives. Masters thesis, Universiti Putra Malaysia. Betulin Esterification English |
| spellingShingle | Betulin Esterification Mohd Ali, Mohd Tajudin Preparations of Betulinic Acid Derivatives |
| title | Preparations of Betulinic Acid Derivatives |
| title_full | Preparations of Betulinic Acid Derivatives |
| title_fullStr | Preparations of Betulinic Acid Derivatives |
| title_full_unstemmed | Preparations of Betulinic Acid Derivatives |
| title_short | Preparations of Betulinic Acid Derivatives |
| title_sort | preparations of betulinic acid derivatives |
| topic | Betulin Esterification |
| url | http://psasir.upm.edu.my/id/eprint/7080/ http://psasir.upm.edu.my/id/eprint/7080/1/FSAS_2004_5%28a%29.pdf |