Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves
This report describes the effect of vaccination with attenuated P. multocida B:2 on wild-type P. multocida B:2 infection in calves. Calves were given 5 ml intranasal 107 CFU/mL live attenuated gdhA derivative of P. multocida B:2. Untreated calves were then mingled with the vaccinated Group. Control...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Online Journal of Veterinary Research
2009
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/7064/ http://psasir.upm.edu.my/id/eprint/7064/1/Effect%20of%20intranasal%20attenuated%20Pasteurella%20multocida%20B.pdf |
| _version_ | 1848840492901466112 |
|---|---|
| author | Khin, Myat Nwe Saad, Mohd Zamri Mohamed Mustapha, Noordin Abd Wahid, Mohd Effendy |
| author_facet | Khin, Myat Nwe Saad, Mohd Zamri Mohamed Mustapha, Noordin Abd Wahid, Mohd Effendy |
| author_sort | Khin, Myat Nwe |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | This report describes the effect of vaccination with attenuated P. multocida B:2 on wild-type P. multocida B:2 infection in calves. Calves were given 5 ml intranasal 107 CFU/mL live attenuated gdhA derivative of P. multocida B:2. Untreated calves were then mingled with the vaccinated Group. Control untreated calves were kept separate. After 6 weeks, all calves were challenged intra-tracheally with 107 CFU/mL of live wild-type P. multocida B:2. At Post-Mortem none of the vaccinated or mingled calves had lesions whereas controls revealed pulmonary petechial haemorrhages with acute pneumonia patches with neutrophils. Both exposed and commingled calves showed significantly (p<0.05) higher levels of serum IgG. P. multocida B:2 were successfully isolated only from the control calves of Group 3. These findings suggest that intranasal exposures to live attenuated P. multocida B:2 prevented infection by wild-type P. multocida B:2 and may have protected susceptible calves. |
| first_indexed | 2025-11-15T07:28:13Z |
| format | Article |
| id | upm-7064 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:28:13Z |
| publishDate | 2009 |
| publisher | Online Journal of Veterinary Research |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-70642016-11-22T01:09:45Z http://psasir.upm.edu.my/id/eprint/7064/ Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves Khin, Myat Nwe Saad, Mohd Zamri Mohamed Mustapha, Noordin Abd Wahid, Mohd Effendy This report describes the effect of vaccination with attenuated P. multocida B:2 on wild-type P. multocida B:2 infection in calves. Calves were given 5 ml intranasal 107 CFU/mL live attenuated gdhA derivative of P. multocida B:2. Untreated calves were then mingled with the vaccinated Group. Control untreated calves were kept separate. After 6 weeks, all calves were challenged intra-tracheally with 107 CFU/mL of live wild-type P. multocida B:2. At Post-Mortem none of the vaccinated or mingled calves had lesions whereas controls revealed pulmonary petechial haemorrhages with acute pneumonia patches with neutrophils. Both exposed and commingled calves showed significantly (p<0.05) higher levels of serum IgG. P. multocida B:2 were successfully isolated only from the control calves of Group 3. These findings suggest that intranasal exposures to live attenuated P. multocida B:2 prevented infection by wild-type P. multocida B:2 and may have protected susceptible calves. Online Journal of Veterinary Research 2009 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/7064/1/Effect%20of%20intranasal%20attenuated%20Pasteurella%20multocida%20B.pdf Khin, Myat Nwe and Saad, Mohd Zamri and Mohamed Mustapha, Noordin and Abd Wahid, Mohd Effendy (2009) Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves. Online Journal of Veterinary Research, 13 (2). pp. 65-72. ISSN 1328-925X http://onljvetres.com/pasteurellaabs2009.htm |
| spellingShingle | Khin, Myat Nwe Saad, Mohd Zamri Mohamed Mustapha, Noordin Abd Wahid, Mohd Effendy Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves |
| title | Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves |
| title_full | Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves |
| title_fullStr | Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves |
| title_full_unstemmed | Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves |
| title_short | Effect of intranasal attenuated Pasteurella multocida B:2 on haemorrhagic septicaemia in calves |
| title_sort | effect of intranasal attenuated pasteurella multocida b:2 on haemorrhagic septicaemia in calves |
| url | http://psasir.upm.edu.my/id/eprint/7064/ http://psasir.upm.edu.my/id/eprint/7064/ http://psasir.upm.edu.my/id/eprint/7064/1/Effect%20of%20intranasal%20attenuated%20Pasteurella%20multocida%20B.pdf |