Respiratory macrophage activity and pulmonary morphology following exposure to benzo(a)pyrene in broilers
The effect of benzo(a)pyrene (BaP) on the macrophage defense system and lung morphology in broilers was evaluated. One day age chicks were divided into 4 groups of 40. Control chicks were given tricaprylin alone intratracheally (IT), while treated groups were given BaP (viz, at 1.5 micro g, 150 micr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Online Journal of Veterinary Research
2009
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| Online Access: | http://psasir.upm.edu.my/id/eprint/7063/ http://psasir.upm.edu.my/id/eprint/7063/1/Respiratory%20macrophage%20activity%20and%20pulmonary%20morphology%20following%20exposure%20to%20benzo.pdf |
| _version_ | 1848840492650856448 |
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| author | Latif, I. K. Karim, Abdulkarim Jafar Abu Bakar @ Zakaria, Md Zuki Saad, Mohd Zamri Niu, J. P. Mohamed Mustapha, Noordin |
| author_facet | Latif, I. K. Karim, Abdulkarim Jafar Abu Bakar @ Zakaria, Md Zuki Saad, Mohd Zamri Niu, J. P. Mohamed Mustapha, Noordin |
| author_sort | Latif, I. K. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The effect of benzo(a)pyrene (BaP) on the macrophage defense system and lung morphology in broilers was evaluated. One day age chicks were divided into 4 groups of 40. Control chicks were given tricaprylin alone intratracheally (IT), while treated groups were given BaP (viz, at 1.5 micro g, 150 micro g or 15 mg/kg bodyweight) for 5 consecutive days IT. Ten birds per group were sacrificed at days 7, 14, 21 and 35. Respiratory lavage was performed immediately to procure avian respiratory macrophages (ARM). A significant decrease in the mean values of the given lavage volume, phagocytosis and intracellular killing activities along with an increase in ARM counts was observed especially in the group receiving 15 mg BaP, suggesting a possible immunopulmonary toxic effect of inhaled BaP. |
| first_indexed | 2025-11-15T07:28:12Z |
| format | Article |
| id | upm-7063 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:28:12Z |
| publishDate | 2009 |
| publisher | Online Journal of Veterinary Research |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-70632016-11-21T02:11:36Z http://psasir.upm.edu.my/id/eprint/7063/ Respiratory macrophage activity and pulmonary morphology following exposure to benzo(a)pyrene in broilers Latif, I. K. Karim, Abdulkarim Jafar Abu Bakar @ Zakaria, Md Zuki Saad, Mohd Zamri Niu, J. P. Mohamed Mustapha, Noordin The effect of benzo(a)pyrene (BaP) on the macrophage defense system and lung morphology in broilers was evaluated. One day age chicks were divided into 4 groups of 40. Control chicks were given tricaprylin alone intratracheally (IT), while treated groups were given BaP (viz, at 1.5 micro g, 150 micro g or 15 mg/kg bodyweight) for 5 consecutive days IT. Ten birds per group were sacrificed at days 7, 14, 21 and 35. Respiratory lavage was performed immediately to procure avian respiratory macrophages (ARM). A significant decrease in the mean values of the given lavage volume, phagocytosis and intracellular killing activities along with an increase in ARM counts was observed especially in the group receiving 15 mg BaP, suggesting a possible immunopulmonary toxic effect of inhaled BaP. Online Journal of Veterinary Research 2009 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/7063/1/Respiratory%20macrophage%20activity%20and%20pulmonary%20morphology%20following%20exposure%20to%20benzo.pdf Latif, I. K. and Karim, Abdulkarim Jafar and Abu Bakar @ Zakaria, Md Zuki and Saad, Mohd Zamri and Niu, J. P. and Mohamed Mustapha, Noordin (2009) Respiratory macrophage activity and pulmonary morphology following exposure to benzo(a)pyrene in broilers. Online Journal of Veterinary Research, 13 (2). pp. 128-135. ISSN 1328-925X http://onljvetres.com/macrophageabs2009.htm |
| spellingShingle | Latif, I. K. Karim, Abdulkarim Jafar Abu Bakar @ Zakaria, Md Zuki Saad, Mohd Zamri Niu, J. P. Mohamed Mustapha, Noordin Respiratory macrophage activity and pulmonary morphology following exposure to benzo(a)pyrene in broilers |
| title | Respiratory macrophage activity and pulmonary morphology following exposure to benzo(a)pyrene in broilers |
| title_full | Respiratory macrophage activity and pulmonary morphology following exposure to benzo(a)pyrene in broilers |
| title_fullStr | Respiratory macrophage activity and pulmonary morphology following exposure to benzo(a)pyrene in broilers |
| title_full_unstemmed | Respiratory macrophage activity and pulmonary morphology following exposure to benzo(a)pyrene in broilers |
| title_short | Respiratory macrophage activity and pulmonary morphology following exposure to benzo(a)pyrene in broilers |
| title_sort | respiratory macrophage activity and pulmonary morphology following exposure to benzo(a)pyrene in broilers |
| url | http://psasir.upm.edu.my/id/eprint/7063/ http://psasir.upm.edu.my/id/eprint/7063/ http://psasir.upm.edu.my/id/eprint/7063/1/Respiratory%20macrophage%20activity%20and%20pulmonary%20morphology%20following%20exposure%20to%20benzo.pdf |