Glutathione s-transferase: an overview on distribution of GSTM1 and GSTT1 polymorphisms in Malaysian and other populations
Glutathione s-transferases (GSTs) are the vital enzymes involved in Phase II metabolism to detoxify a wide range of carcinogenic metabolites in the body. GST class mu-1 (GSTM1) and GST class theta-1 (GSTT1) are the genes encoding for the GST isoenzymes. Nevertheless, both genes were frequently repor...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/70058/ http://psasir.upm.edu.my/id/eprint/70058/1/2019070210035513_MJMHS_SP2_2019.pdf |
| _version_ | 1848856582230638592 |
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| author | Wan Rashidi, Wan Nooremira Abu Bakar @ Jamaludin, Suhaili |
| author_facet | Wan Rashidi, Wan Nooremira Abu Bakar @ Jamaludin, Suhaili |
| author_sort | Wan Rashidi, Wan Nooremira |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Glutathione s-transferases (GSTs) are the vital enzymes involved in Phase II metabolism to detoxify a wide range of carcinogenic metabolites in the body. GST class mu-1 (GSTM1) and GST class theta-1 (GSTT1) are the genes encoding for the GST isoenzymes. Nevertheless, both genes were frequently reported absent (null) in most of the populations at different frequencies. Null polymorphism will affect the production of GSTs and impair the ability to eliminate carcinogenic compounds which had been shown to expose null individuals to high risk of several cancers such as gastric and lung cancer. Thus, this review will briefly summarize on the GSTM1 and GSTT1 polymorphisms, frequencies of null variants in populations worldwide, including Malaysian, and their relevancy to the underlying basis of toxicological response to xenobiotics. Additionally, the genotyping assays used in GST studies will also be discussed. |
| first_indexed | 2025-11-15T11:43:57Z |
| format | Article |
| id | upm-70058 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:43:57Z |
| publishDate | 2019 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-700582019-08-16T00:39:13Z http://psasir.upm.edu.my/id/eprint/70058/ Glutathione s-transferase: an overview on distribution of GSTM1 and GSTT1 polymorphisms in Malaysian and other populations Wan Rashidi, Wan Nooremira Abu Bakar @ Jamaludin, Suhaili Glutathione s-transferases (GSTs) are the vital enzymes involved in Phase II metabolism to detoxify a wide range of carcinogenic metabolites in the body. GST class mu-1 (GSTM1) and GST class theta-1 (GSTT1) are the genes encoding for the GST isoenzymes. Nevertheless, both genes were frequently reported absent (null) in most of the populations at different frequencies. Null polymorphism will affect the production of GSTs and impair the ability to eliminate carcinogenic compounds which had been shown to expose null individuals to high risk of several cancers such as gastric and lung cancer. Thus, this review will briefly summarize on the GSTM1 and GSTT1 polymorphisms, frequencies of null variants in populations worldwide, including Malaysian, and their relevancy to the underlying basis of toxicological response to xenobiotics. Additionally, the genotyping assays used in GST studies will also be discussed. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/70058/1/2019070210035513_MJMHS_SP2_2019.pdf Wan Rashidi, Wan Nooremira and Abu Bakar @ Jamaludin, Suhaili (2019) Glutathione s-transferase: an overview on distribution of GSTM1 and GSTT1 polymorphisms in Malaysian and other populations. Malaysian Journal of Medicine and Health Sciences, 15 (SP2). pp. 85-95. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2019070210035513_MJMHS_SP2_2019.pdf |
| spellingShingle | Wan Rashidi, Wan Nooremira Abu Bakar @ Jamaludin, Suhaili Glutathione s-transferase: an overview on distribution of GSTM1 and GSTT1 polymorphisms in Malaysian and other populations |
| title | Glutathione s-transferase: an overview on distribution of GSTM1 and GSTT1 polymorphisms in Malaysian and other populations |
| title_full | Glutathione s-transferase: an overview on distribution of GSTM1 and GSTT1 polymorphisms in Malaysian and other populations |
| title_fullStr | Glutathione s-transferase: an overview on distribution of GSTM1 and GSTT1 polymorphisms in Malaysian and other populations |
| title_full_unstemmed | Glutathione s-transferase: an overview on distribution of GSTM1 and GSTT1 polymorphisms in Malaysian and other populations |
| title_short | Glutathione s-transferase: an overview on distribution of GSTM1 and GSTT1 polymorphisms in Malaysian and other populations |
| title_sort | glutathione s-transferase: an overview on distribution of gstm1 and gstt1 polymorphisms in malaysian and other populations |
| url | http://psasir.upm.edu.my/id/eprint/70058/ http://psasir.upm.edu.my/id/eprint/70058/ http://psasir.upm.edu.my/id/eprint/70058/1/2019070210035513_MJMHS_SP2_2019.pdf |