Acute toxicity study of intravenous administration of thymoquinone-loaded nanostructured lipid carrier (TQ-NLC) in Sprague dawley rats
Introduction: Thymoquinone (TQ), a bioactive compound from Nigella sativa is known for its various medicinal properties. Due to the low solubility of TQ, nanostructured lipid carrier (NLC) has been used as a delivery system to improve its efficacy. Nevertheless, the effect of TQ-NLC when administere...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/70044/ http://psasir.upm.edu.my/id/eprint/70044/1/2019070210012408_MJMHS_SP2_2019.pdf |
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| author | Saiful Yazan, Latifah Mohd Azlan, Siti Nabilahuda Zakarial Ansar, Fatin Hannani Gopalsamy, Banulata |
| author_facet | Saiful Yazan, Latifah Mohd Azlan, Siti Nabilahuda Zakarial Ansar, Fatin Hannani Gopalsamy, Banulata |
| author_sort | Saiful Yazan, Latifah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: Thymoquinone (TQ), a bioactive compound from Nigella sativa is known for its various medicinal properties. Due to the low solubility of TQ, nanostructured lipid carrier (NLC) has been used as a delivery system to improve its efficacy. Nevertheless, the effect of TQ-NLC when administered intravenously is unclear. This study investigated the acute toxicity profile of intravenous administration of TQ-NLC in an in vivo model. Methods: Twelve female Sprague dawley rats were assigned randomly into two groups (n=6); a control and a treatment group that received normal saline and 25 mg/kg TQ-NLC, respectively, via intravenous injection. The rats were observed for 14 days for any alterations to their usual physical conditions such as behaviour and mortality, body weight, food intake, organ-to-body weight ratio, and haematological, biochemical and histopathological profile. Results: There were no significant changes (p>0.05) in the body weight, food intake, organ-to-body weight ratio, and haematological, bio-chemical and histopathological profile between TQ-NLC treatment and the control group. However, inflammation was observed at the site of injection on the rat’s tail. Conclusion: Intravenous administration of TQ-NLC (25 mg/kg) did not exert acute toxic effect in female Sprague dawley rats. The data can be used as a basis to further develop TQ-NLC as a potential therapeutic drug. |
| first_indexed | 2025-11-15T11:43:53Z |
| format | Article |
| id | upm-70044 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:43:53Z |
| publishDate | 2019 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-700442019-08-16T00:38:55Z http://psasir.upm.edu.my/id/eprint/70044/ Acute toxicity study of intravenous administration of thymoquinone-loaded nanostructured lipid carrier (TQ-NLC) in Sprague dawley rats Saiful Yazan, Latifah Mohd Azlan, Siti Nabilahuda Zakarial Ansar, Fatin Hannani Gopalsamy, Banulata Introduction: Thymoquinone (TQ), a bioactive compound from Nigella sativa is known for its various medicinal properties. Due to the low solubility of TQ, nanostructured lipid carrier (NLC) has been used as a delivery system to improve its efficacy. Nevertheless, the effect of TQ-NLC when administered intravenously is unclear. This study investigated the acute toxicity profile of intravenous administration of TQ-NLC in an in vivo model. Methods: Twelve female Sprague dawley rats were assigned randomly into two groups (n=6); a control and a treatment group that received normal saline and 25 mg/kg TQ-NLC, respectively, via intravenous injection. The rats were observed for 14 days for any alterations to their usual physical conditions such as behaviour and mortality, body weight, food intake, organ-to-body weight ratio, and haematological, biochemical and histopathological profile. Results: There were no significant changes (p>0.05) in the body weight, food intake, organ-to-body weight ratio, and haematological, bio-chemical and histopathological profile between TQ-NLC treatment and the control group. However, inflammation was observed at the site of injection on the rat’s tail. Conclusion: Intravenous administration of TQ-NLC (25 mg/kg) did not exert acute toxic effect in female Sprague dawley rats. The data can be used as a basis to further develop TQ-NLC as a potential therapeutic drug. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/70044/1/2019070210012408_MJMHS_SP2_2019.pdf Saiful Yazan, Latifah and Mohd Azlan, Siti Nabilahuda and Zakarial Ansar, Fatin Hannani and Gopalsamy, Banulata (2019) Acute toxicity study of intravenous administration of thymoquinone-loaded nanostructured lipid carrier (TQ-NLC) in Sprague dawley rats. Malaysian Journal of Medicine and Health Sciences, 15 (SP2). pp. 51-57. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2019070210012408_MJMHS_SP2_2019.pdf |
| spellingShingle | Saiful Yazan, Latifah Mohd Azlan, Siti Nabilahuda Zakarial Ansar, Fatin Hannani Gopalsamy, Banulata Acute toxicity study of intravenous administration of thymoquinone-loaded nanostructured lipid carrier (TQ-NLC) in Sprague dawley rats |
| title | Acute toxicity study of intravenous administration of thymoquinone-loaded nanostructured lipid carrier (TQ-NLC) in Sprague dawley rats |
| title_full | Acute toxicity study of intravenous administration of thymoquinone-loaded nanostructured lipid carrier (TQ-NLC) in Sprague dawley rats |
| title_fullStr | Acute toxicity study of intravenous administration of thymoquinone-loaded nanostructured lipid carrier (TQ-NLC) in Sprague dawley rats |
| title_full_unstemmed | Acute toxicity study of intravenous administration of thymoquinone-loaded nanostructured lipid carrier (TQ-NLC) in Sprague dawley rats |
| title_short | Acute toxicity study of intravenous administration of thymoquinone-loaded nanostructured lipid carrier (TQ-NLC) in Sprague dawley rats |
| title_sort | acute toxicity study of intravenous administration of thymoquinone-loaded nanostructured lipid carrier (tq-nlc) in sprague dawley rats |
| url | http://psasir.upm.edu.my/id/eprint/70044/ http://psasir.upm.edu.my/id/eprint/70044/ http://psasir.upm.edu.my/id/eprint/70044/1/2019070210012408_MJMHS_SP2_2019.pdf |