Effects of Ostertagia ostertagi and omeprazole treatment on feed intake and gastrin-related responses in the calf
Infection with the bovine abomasal nematode, Ostertagia ostertagi, results in a loss of acid-secreting parietal cells and an increase in gastric pH. The effects of an experimental infection with Ostertagia and/or daily treatment with omeprazole (OMP) at 2 mg kg−1 bodyweight for four consecutive days...
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| Format: | Article |
| Language: | English English English |
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Elsevier Science
2002
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| Online Access: | http://psasir.upm.edu.my/id/eprint/6966/ http://psasir.upm.edu.my/id/eprint/6966/1/Effects%20of%20Ostertagia%20ostertagi%20and%20omeprazole%20treatment%20on%20feed%20intake%20and%20gastrin.pdf http://psasir.upm.edu.my/id/eprint/6966/7/1-s2.0-S0304401702000262-main.pdf |
| _version_ | 1848840465160339456 |
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| author | Fox, Mark T. Uche, U. E. Vaillant, Camille Ganabadi, Shanti Calam, John |
| author_facet | Fox, Mark T. Uche, U. E. Vaillant, Camille Ganabadi, Shanti Calam, John |
| author_sort | Fox, Mark T. |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Infection with the bovine abomasal nematode, Ostertagia ostertagi, results in a loss of acid-secreting parietal cells and an increase in gastric pH. The effects of an experimental infection with Ostertagia and/or daily treatment with omeprazole (OMP) at 2 mg kg−1 bodyweight for four consecutive days (experiment days 24–27, inclusive) on voluntary feed intake, blood and tissue gastrin concentrations, abomasal G-cell numbers, gastric pH, and blood cholecystokinin (CCK) and pepsinogen concentrations were investigated in the calf. Ostertagia-infected calves demonstrated a significant drop in feed intake between days 24 and 27 post-infection (38%; P<0.001) and in G-cell numbers (42%; P<0.05) and significant increases in abomasal pH (P<0.001), fundic mucosal weight (99%; P<0.01), and blood gastrin (P<0.05) and pepsinogen (P<0.0001). OMP treatment of worm-free animals resulted in a significant drop in intake between days 24 and 27 (30%; P<0.001) and in G-cell numbers (17%; P<0.05) and significant increases in abomasal pH (P<0.01) and blood gastrin (P<0.001). OMP treatment of Ostertagia-infected animals with an existing hypergastrinaemia had no effect on feed intake, abomasal pH, blood gastrin or pepsinogen or abomasal G-cell numbers. Blood CCK concentrations were also unaffected by either Ostertagia infection or OMP treatment. These data suggest that: (a) the depression in feed intake associated with OMP in worm-free calves was not due to a side effect of drug treatment; (b) inappetance in Ostertagia-infected animals is closely associated with the parasite-induced hypergastrinaemia; and (c) the elevation in abomasal pH was a major factor responsible for the elevated blood gastrin concentrations seen in parasitised and OMP-treated animals. |
| first_indexed | 2025-11-15T07:27:46Z |
| format | Article |
| id | upm-6966 |
| institution | Universiti Putra Malaysia |
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| language | English English English |
| last_indexed | 2025-11-15T07:27:46Z |
| publishDate | 2002 |
| publisher | Elsevier Science |
| recordtype | eprints |
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| spelling | upm-69662024-08-05T08:10:26Z http://psasir.upm.edu.my/id/eprint/6966/ Effects of Ostertagia ostertagi and omeprazole treatment on feed intake and gastrin-related responses in the calf Fox, Mark T. Uche, U. E. Vaillant, Camille Ganabadi, Shanti Calam, John Infection with the bovine abomasal nematode, Ostertagia ostertagi, results in a loss of acid-secreting parietal cells and an increase in gastric pH. The effects of an experimental infection with Ostertagia and/or daily treatment with omeprazole (OMP) at 2 mg kg−1 bodyweight for four consecutive days (experiment days 24–27, inclusive) on voluntary feed intake, blood and tissue gastrin concentrations, abomasal G-cell numbers, gastric pH, and blood cholecystokinin (CCK) and pepsinogen concentrations were investigated in the calf. Ostertagia-infected calves demonstrated a significant drop in feed intake between days 24 and 27 post-infection (38%; P<0.001) and in G-cell numbers (42%; P<0.05) and significant increases in abomasal pH (P<0.001), fundic mucosal weight (99%; P<0.01), and blood gastrin (P<0.05) and pepsinogen (P<0.0001). OMP treatment of worm-free animals resulted in a significant drop in intake between days 24 and 27 (30%; P<0.001) and in G-cell numbers (17%; P<0.05) and significant increases in abomasal pH (P<0.01) and blood gastrin (P<0.001). OMP treatment of Ostertagia-infected animals with an existing hypergastrinaemia had no effect on feed intake, abomasal pH, blood gastrin or pepsinogen or abomasal G-cell numbers. Blood CCK concentrations were also unaffected by either Ostertagia infection or OMP treatment. These data suggest that: (a) the depression in feed intake associated with OMP in worm-free calves was not due to a side effect of drug treatment; (b) inappetance in Ostertagia-infected animals is closely associated with the parasite-induced hypergastrinaemia; and (c) the elevation in abomasal pH was a major factor responsible for the elevated blood gastrin concentrations seen in parasitised and OMP-treated animals. Elsevier Science 2002-01-10 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/6966/1/Effects%20of%20Ostertagia%20ostertagi%20and%20omeprazole%20treatment%20on%20feed%20intake%20and%20gastrin.pdf text en http://psasir.upm.edu.my/id/eprint/6966/7/1-s2.0-S0304401702000262-main.pdf Fox, Mark T. and Uche, U. E. and Vaillant, Camille and Ganabadi, Shanti and Calam, John (2002) Effects of Ostertagia ostertagi and omeprazole treatment on feed intake and gastrin-related responses in the calf. Veterinary Parasitology, 105 (4). pp. 285-301. ISSN 0304-4017 http://dx.doi.org/10.1016/S0304-4017(02)00026-2 10.1016/S0304-4017(02)00026-2 English |
| spellingShingle | Fox, Mark T. Uche, U. E. Vaillant, Camille Ganabadi, Shanti Calam, John Effects of Ostertagia ostertagi and omeprazole treatment on feed intake and gastrin-related responses in the calf |
| title | Effects of Ostertagia ostertagi and omeprazole treatment on feed intake and gastrin-related responses in the calf |
| title_full | Effects of Ostertagia ostertagi and omeprazole treatment on feed intake and gastrin-related responses in the calf |
| title_fullStr | Effects of Ostertagia ostertagi and omeprazole treatment on feed intake and gastrin-related responses in the calf |
| title_full_unstemmed | Effects of Ostertagia ostertagi and omeprazole treatment on feed intake and gastrin-related responses in the calf |
| title_short | Effects of Ostertagia ostertagi and omeprazole treatment on feed intake and gastrin-related responses in the calf |
| title_sort | effects of ostertagia ostertagi and omeprazole treatment on feed intake and gastrin-related responses in the calf |
| url | http://psasir.upm.edu.my/id/eprint/6966/ http://psasir.upm.edu.my/id/eprint/6966/ http://psasir.upm.edu.my/id/eprint/6966/ http://psasir.upm.edu.my/id/eprint/6966/1/Effects%20of%20Ostertagia%20ostertagi%20and%20omeprazole%20treatment%20on%20feed%20intake%20and%20gastrin.pdf http://psasir.upm.edu.my/id/eprint/6966/7/1-s2.0-S0304401702000262-main.pdf |