Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V
Summary. Nucleotide sequence comparison of the L gene of the Malaysian neurotropic-viscerotropic velogenic NDV strain AF2240 with other NDV strains revealed a single nucleotide insertion at position 3870. This mutation is compensated by a nucleotide deletion downstream at position 3958 which results...
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| Format: | Article |
| Language: | English English |
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Springer Wien
2004
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| Online Access: | http://psasir.upm.edu.my/id/eprint/693/ http://psasir.upm.edu.my/id/eprint/693/1/PFBSB7.pdf |
| _version_ | 1848838840794480640 |
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| author | Kusumaningtyas, Eni Tan, Wen Siang Zamrod, Zulkeflie Eshaghi, Majid Yusoff, Khatijah |
| author_facet | Kusumaningtyas, Eni Tan, Wen Siang Zamrod, Zulkeflie Eshaghi, Majid Yusoff, Khatijah |
| author_sort | Kusumaningtyas, Eni |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Summary. Nucleotide sequence comparison of the L gene of the Malaysian neurotropic-viscerotropic velogenic NDV strain AF2240 with other NDV strains revealed a single nucleotide insertion at position 3870. This mutation is compensated by a nucleotide deletion downstream at position 3958 which results in two forms of the L proteins containing a 30-amino acid substitution in Domain V. This compensatory mutation this does not correlate with the pathogenicity of the viral strains but is may affect the viral replication as Domain V is believed to play an important role in the replication of paramyxoviruses. |
| first_indexed | 2025-11-15T07:01:57Z |
| format | Article |
| id | upm-693 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T07:01:57Z |
| publishDate | 2004 |
| publisher | Springer Wien |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-6932013-05-27T06:50:12Z http://psasir.upm.edu.my/id/eprint/693/ Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V Kusumaningtyas, Eni Tan, Wen Siang Zamrod, Zulkeflie Eshaghi, Majid Yusoff, Khatijah Summary. Nucleotide sequence comparison of the L gene of the Malaysian neurotropic-viscerotropic velogenic NDV strain AF2240 with other NDV strains revealed a single nucleotide insertion at position 3870. This mutation is compensated by a nucleotide deletion downstream at position 3958 which results in two forms of the L proteins containing a 30-amino acid substitution in Domain V. This compensatory mutation this does not correlate with the pathogenicity of the viral strains but is may affect the viral replication as Domain V is believed to play an important role in the replication of paramyxoviruses. Springer Wien 2004 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/693/1/PFBSB7.pdf Kusumaningtyas, Eni and Tan, Wen Siang and Zamrod, Zulkeflie and Eshaghi, Majid and Yusoff, Khatijah (2004) Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V. Archives of Virology, 149 (1). pp. 1859-1865. ISSN 0304-8608 http://dx.doi.org/10.1007/s00705-004-0336-5 English |
| spellingShingle | Kusumaningtyas, Eni Tan, Wen Siang Zamrod, Zulkeflie Eshaghi, Majid Yusoff, Khatijah Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V |
| title | Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V |
| title_full | Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V |
| title_fullStr | Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V |
| title_full_unstemmed | Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V |
| title_short | Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V |
| title_sort | existence of two form of l protein of newcastle disease virus isolates due to a compensatory mutation in domain v |
| url | http://psasir.upm.edu.my/id/eprint/693/ http://psasir.upm.edu.my/id/eprint/693/ http://psasir.upm.edu.my/id/eprint/693/1/PFBSB7.pdf |