Post-weaning exposure to bisphenol A induces histological changes in the liver
Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) widely used in industry as a plasticizer for the production of polycarbonate plastics and epoxy resins. The liver is highly sensitive to BPA, even at low doses. The objective of the study is to investigate the effect of BPA on histo-archite...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Universiti Putra Malaysia Press
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/68704/ http://psasir.upm.edu.my/id/eprint/68704/1/26%20JST%28S%29-0483-2019.pdf |
| _version_ | 1848856202888347648 |
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| author | Mohamad Zaid, Siti Sarah Rohim, Siti Nur Hajar Goh, Yong Meng Mohamed Mustapha, Noordin |
| author_facet | Mohamad Zaid, Siti Sarah Rohim, Siti Nur Hajar Goh, Yong Meng Mohamed Mustapha, Noordin |
| author_sort | Mohamad Zaid, Siti Sarah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) widely used in industry as a plasticizer for the production of polycarbonate plastics and epoxy resins. The liver is highly sensitive to BPA, even at low doses. The objective of the study is to investigate the effect of BPA on histo-architecture of the liver in post-weaning rats. Post-weaning female rats were exposed to BPA by oral gavage over a six weeks period. The results showed that even at low environmental doses, BPA exposure had adverse effects on the liver histo-architecture, thereby disrupting the functions of cellular. The administration of BPA resulted in severe hepatocytes necrosis, dilated sinusoid, and depicting features of conspicuous Kupffer cells. The results may be due to the generation of reactive oxygen species (ROS) by BPA. In conclusion, post-weaning exposure of BPA resulted in significant histological alterations due to ROS generation. |
| first_indexed | 2025-11-15T11:37:55Z |
| format | Article |
| id | upm-68704 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:37:55Z |
| publishDate | 2019 |
| publisher | Universiti Putra Malaysia Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-687042019-06-10T03:00:30Z http://psasir.upm.edu.my/id/eprint/68704/ Post-weaning exposure to bisphenol A induces histological changes in the liver Mohamad Zaid, Siti Sarah Rohim, Siti Nur Hajar Goh, Yong Meng Mohamed Mustapha, Noordin Bisphenol A (BPA) is an endocrine disrupting chemical (EDC) widely used in industry as a plasticizer for the production of polycarbonate plastics and epoxy resins. The liver is highly sensitive to BPA, even at low doses. The objective of the study is to investigate the effect of BPA on histo-architecture of the liver in post-weaning rats. Post-weaning female rats were exposed to BPA by oral gavage over a six weeks period. The results showed that even at low environmental doses, BPA exposure had adverse effects on the liver histo-architecture, thereby disrupting the functions of cellular. The administration of BPA resulted in severe hepatocytes necrosis, dilated sinusoid, and depicting features of conspicuous Kupffer cells. The results may be due to the generation of reactive oxygen species (ROS) by BPA. In conclusion, post-weaning exposure of BPA resulted in significant histological alterations due to ROS generation. Universiti Putra Malaysia Press 2019 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/68704/1/26%20JST%28S%29-0483-2019.pdf Mohamad Zaid, Siti Sarah and Rohim, Siti Nur Hajar and Goh, Yong Meng and Mohamed Mustapha, Noordin (2019) Post-weaning exposure to bisphenol A induces histological changes in the liver. Pertanika Journal of Science & Technology, 27 (2). pp. 943-951. ISSN 0128-7680; ESSN: 2231-8526 http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JST%20Vol.%2027%20(2)%20Apr.%202019/26%20JST(S)-0483-2019.pdf |
| spellingShingle | Mohamad Zaid, Siti Sarah Rohim, Siti Nur Hajar Goh, Yong Meng Mohamed Mustapha, Noordin Post-weaning exposure to bisphenol A induces histological changes in the liver |
| title | Post-weaning exposure to bisphenol A induces histological changes in the liver |
| title_full | Post-weaning exposure to bisphenol A induces histological changes in the liver |
| title_fullStr | Post-weaning exposure to bisphenol A induces histological changes in the liver |
| title_full_unstemmed | Post-weaning exposure to bisphenol A induces histological changes in the liver |
| title_short | Post-weaning exposure to bisphenol A induces histological changes in the liver |
| title_sort | post-weaning exposure to bisphenol a induces histological changes in the liver |
| url | http://psasir.upm.edu.my/id/eprint/68704/ http://psasir.upm.edu.my/id/eprint/68704/ http://psasir.upm.edu.my/id/eprint/68704/1/26%20JST%28S%29-0483-2019.pdf |