Design, synthesis, and biochemical assay of peptide inhibitors derived from α-enolase for use against peptidylarginine deiminase type 4

QR Code

Design, synthesis, and biochemical assay of peptide inhibitors derived from α-enolase for use against peptidylarginine deiminase type 4

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease affecting about 0.5–1.0% of the world population. Peptidylarginine deiminase type 4 (PAD4) is a responsible protein for the occurrence of RA by catalyzing citrullination of proteins. The citrullinated proteins act as autoantigens by sti...

Full description

Bibliographic Details
Main Author:	Ahmad Nadzirin, Izzuddin
Format:	Thesis
Language:	English
Published:	2013
Subjects:	Arthritis Peptides - Synthesis
Online Access:	http://psasir.upm.edu.my/id/eprint/67427/ http://psasir.upm.edu.my/id/eprint/67427/1/FS%202013%2059%20IR.pdf

Similar Items

Discovery of new inhibitor for the protein arginine deiminase type 4 (PAD4) by rational design of α-enolase-derived peptides
by: Ahmad Nadzirin, Izzuddin, et al.
Published: (2021)

Towards an Understanding of the Role of VGF-Derived Peptides
by: Ashford, Toni Winona Marie
Published: (2021)

Cyclization enhances function of linear anti-arthritic peptides
by: Ali, Marina, et al.
Published: (2014)

Characterization of peptides and proteins from epidermal mucus of climbing perch Anabas testudineus (Bloch, 1972) with antibacterial and immunomodulatory properties
by: Hussein, Agharid Ali
Published: (2018)

Copper-peptides mimicking catalytic activity of laccase in oxidation reactions
by: Begum, Sharifa Zaithun
Published: (2020)

Total synthesis of the post-translationally modified polyazole peptide antibiotic goadsporin
by: Dexter, Hannah L., et al.
Published: (2017)

Photocatalytic Tryptophan Alkylation for Chemoselective Peptide Modification
by: Lee, Joanna
Published: (2024)

Synthesis and characterization of novel palmitic acid conjugated tetrapeptide as a new active molecule for wound treatment
by: Md Fadilah, Nur Izzah
Published: (2020)

Solution phase synthesis and characterization of peptidyl chemosensors for Pb (ll) and As (lll) detection
by: Abdull Manap, Mohd Rashidi
Published: (2012)

Microneedle Enhanced Delivery of Cosmeceutically Relevant Peptides in Human Skin
by: Mohammed, Yousuf, et al.
Published: (2014)

Peptide inhibitors of xenoreactive antibodies mimic the interaction profile of the native carbohydrate antigens
by: Agostino, Mark, et al.
Published: (2011)

Selection of High Affinity Peptides Against Hepatitis B Core Antigen from a Phage-Displayed Cyclic Peptide Library
by: Ho, Kok Lian
Published: (2002)

Investigation of the effects of VGF overexpression and VGF-derived peptides on lipolysis in 3T3-L1 cells
by: Dean, Holly
Published: (2022)

Antifungal Peptide Modeling, Folding and Mimetic Design
by: Moradi, Shoeib
Published: (2009)

Development of proteomic technique for potential species-specific peptide marker discovery of commercial seasoning cubes
by: Mohd Asri, Ummu Nasuha
Published: (2020)

Anti-arthritic effects of 6-mercaptopurine and its derivatives in arthritis-induced model, In vitro and In vivo
by: Che Ku Daud, Che Ku Dahlan
Published: (2020)

One-pot ligation-oxidative deselenization at selenocysteine and selenocystine
by: Payne, Richard J., et al.
Published: (2017)

Factors predicting pain and early discontinuation of tumour necrosis factor-α-inhibitors in people with rheumatoid arthritis: Results from the British Society for Rheumatology Biologics Register
by: McWilliams, Daniel F., et al.
Published: (2016)

Anti-arthritic action of cardamonin in rheumatoid arthritis-induced rat model
by: Voon, Fui Ling
Published: (2016)

Structure-based design of peptide inhibitors for Protein Arginine Deiminase Type IV (PAD4)
by: Teo, Chian Ying, et al.
Published: (2018)

The development of novel antimicrobial peptides with activity against MRSA
by: Pritchard, Kevin
Published: (2008)

Identification of antifungal peptides produced by Lactobacillus plantarum IS10 grown in the MRS broth
by: Muhialdin, Belal J., et al.
Published: (2016)

Dimerization as a strategy to engineer antimicrobial peptides for application against enteric bacterial pathogens of poultry
by: Pitchers, Kieran
Published: (2022)

Novel furan-containing peptide-based inhibitors of protein arginine deiminase type IV (PAD4)
by: Teo, Chian Ying, et al.
Published: (2017)

Accelerated protein synthesis via one–pot ligation–deselenization chemistry
by: Mitchell, Nicholas J., et al.
Published: (2017)

Polyoxometalates and peptides: hybridisation and disulfide detection
by: Damian, Heather Anne
Published: (2022)

Screening, design, synthesis and bioactivity of inhibitors against Protein Arginine Deiminase type IV
by: Teo, Chian Ying
Published: (2015)

Development of Biosensor for Determination of Cd(11) and Hg(11) Ion by Exploiting MWCNT/Peptide Nanohybrid Modified Au Electrode
by: Abdul Rahman, Nadiah
Published: (2011)

The discovery and characterisation of novel antimicrobial peptides against bacterial pathogens with porcine host specificity.
by: Clarke, Britany
Published: (2023)

Citrullinated α-enolase is an effective target for anti-cancer immunity
by: Cook, Katherine, et al.
Published: (2018)

Identification And Characterization Of A Novel Anti-Viral Peptide Against Avian Influenza Virus H9n2
by: Rajik, Mohamed
Published: (2009)

Development of As(III) and Hg(II) sensors utilizing amino acids and peptides as recognition elements
by: Daud, Nurulhaidah
Published: (2012)

Recovery of peptide from Nannochloropsis gaditana protein hydrolysate through two-stage ultrafiltration membrane
by: Md Saleh, Nur Izzati
Published: (2021)

Host defence peptide (HDP) human beta defensin 9 (HBD9)
by: Omar, Nazri
Published: (2016)

Carbohydrate-mimetic peptides: structural aspects of mimicry and therapeutic implications
by: Agostino, Mark, et al.
Published: (2011)

A Minimal Peptide Scaffold for [4Fe-4S]-Cluster Interrogation and Catalysis
by: Andrea, Bombana
Published: (2024)

Development of quinone-rich fraction of Ardisia crispa (Thunb.) A.DC roots mitigates rheumatoid arthritis by suppressing angiogenesis, in vitro and in vivo
by: Blin, Joan
Published: (2021)

Hetero-Ligand peptide functionalization of gold nanoparticles for selective detection of cobalt (II) ions
by: Jamadon, Nur Khaliesah
Published: (2022)

Production of novel antimicrobial peptide human beta defensin 9 and its efficacy against common eye pathogenic bacteria in different salt concentration
by: Ab Hamid, Nurul Atikah
Published: (2018)

The role of b-type natriuretic peptide in heart failure management
by: Newton, Phillip, et al.
Published: (2009)