Platelet transcriptome-based approaches in the fight against dengue and other diseases
Human platelets are anucleate cells that lack in deoxyribonucleic acid (DNA), thus hampering genomic study on them. However, the presence of their own messenger ribonucleic acid (mRNA) transcript allows functional study via the transcriptome approach. Transcriptome not only allows profiling of plate...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Universiti Putra Malaysia Press
2018
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| Online Access: | http://psasir.upm.edu.my/id/eprint/66302/ http://psasir.upm.edu.my/id/eprint/66302/1/03%20JST-0952-2017-3rdProof.pdf |
| _version_ | 1848855530234183680 |
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| author | Suppiah, Jeyanthi Syed, Sakinah Chan, Shie Yien Wong, Yien Ping Bala, Jamilu Abubakar Lawal, Nafi'u Benelli, Giovanni Subbiah, Suresh Kumar Chee, Hui Yee |
| author_facet | Suppiah, Jeyanthi Syed, Sakinah Chan, Shie Yien Wong, Yien Ping Bala, Jamilu Abubakar Lawal, Nafi'u Benelli, Giovanni Subbiah, Suresh Kumar Chee, Hui Yee |
| author_sort | Suppiah, Jeyanthi |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Human platelets are anucleate cells that lack in deoxyribonucleic acid (DNA), thus hampering genomic study on them. However, the presence of their own messenger ribonucleic acid (mRNA) transcript allows functional study via the transcriptome approach. Transcriptome not only allows profiling of platelet but also aids in studying gene regulation in virus infections and other diseases that have an impact on platelets. Some viruses are known to affect the platelet either by causing a reduction or destruction. Dengue virus is one of the most postulated virus having such effect and frequently linked to platelet reduction. The transcriptome approach has a pivotal role in providing a deeper insight to link certain diseases and their effect on platelets. This review critically discusses role of platelet in dengue and other viral diseases of public health relevance, with a specific focus on the methods currently used in platelet transcriptome profiling. |
| first_indexed | 2025-11-15T11:27:13Z |
| format | Article |
| id | upm-66302 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:27:13Z |
| publishDate | 2018 |
| publisher | Universiti Putra Malaysia Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-663022019-02-12T07:04:04Z http://psasir.upm.edu.my/id/eprint/66302/ Platelet transcriptome-based approaches in the fight against dengue and other diseases Suppiah, Jeyanthi Syed, Sakinah Chan, Shie Yien Wong, Yien Ping Bala, Jamilu Abubakar Lawal, Nafi'u Benelli, Giovanni Subbiah, Suresh Kumar Chee, Hui Yee Human platelets are anucleate cells that lack in deoxyribonucleic acid (DNA), thus hampering genomic study on them. However, the presence of their own messenger ribonucleic acid (mRNA) transcript allows functional study via the transcriptome approach. Transcriptome not only allows profiling of platelet but also aids in studying gene regulation in virus infections and other diseases that have an impact on platelets. Some viruses are known to affect the platelet either by causing a reduction or destruction. Dengue virus is one of the most postulated virus having such effect and frequently linked to platelet reduction. The transcriptome approach has a pivotal role in providing a deeper insight to link certain diseases and their effect on platelets. This review critically discusses role of platelet in dengue and other viral diseases of public health relevance, with a specific focus on the methods currently used in platelet transcriptome profiling. Universiti Putra Malaysia Press 2018 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/66302/1/03%20JST-0952-2017-3rdProof.pdf Suppiah, Jeyanthi and Syed, Sakinah and Chan, Shie Yien and Wong, Yien Ping and Bala, Jamilu Abubakar and Lawal, Nafi'u and Benelli, Giovanni and Subbiah, Suresh Kumar and Chee, Hui Yee (2018) Platelet transcriptome-based approaches in the fight against dengue and other diseases. Pertanika Journal of Science & Technology, 26 (3). pp. 933-946. ISSN 0128-7680; ESSN: 2231-8526 http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JST%20Vol.%2026%20(3)%20Jul.%202018/03%20JST-0952-2017-3rdProof.pdf |
| spellingShingle | Suppiah, Jeyanthi Syed, Sakinah Chan, Shie Yien Wong, Yien Ping Bala, Jamilu Abubakar Lawal, Nafi'u Benelli, Giovanni Subbiah, Suresh Kumar Chee, Hui Yee Platelet transcriptome-based approaches in the fight against dengue and other diseases |
| title | Platelet transcriptome-based approaches in the fight against dengue and other diseases |
| title_full | Platelet transcriptome-based approaches in the fight against dengue and other diseases |
| title_fullStr | Platelet transcriptome-based approaches in the fight against dengue and other diseases |
| title_full_unstemmed | Platelet transcriptome-based approaches in the fight against dengue and other diseases |
| title_short | Platelet transcriptome-based approaches in the fight against dengue and other diseases |
| title_sort | platelet transcriptome-based approaches in the fight against dengue and other diseases |
| url | http://psasir.upm.edu.my/id/eprint/66302/ http://psasir.upm.edu.my/id/eprint/66302/ http://psasir.upm.edu.my/id/eprint/66302/1/03%20JST-0952-2017-3rdProof.pdf |