The effect of non-steroidal anti-inflammatory drugs on carrageenan-induced paw oedema in rats
Ketoprofen, meloxicam, celecoxib and rofecoxib were used in the present study to investigate the effects of NSAIDs on carrageenan-induced paw oedema in rats. Acute inflammation was induced by subplantar injection of carrageenan (0.1 ml, 1 % w/v) into the rat hind paw. Celecoxib (10 mg/kg) caused sig...
| Main Authors: | , , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
Universiti Putra Malaysia Press
2004
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| Online Access: | http://psasir.upm.edu.my/id/eprint/65116/ http://psasir.upm.edu.my/id/eprint/65116/1/71-32.pdf |
| _version_ | 1848855196369682432 |
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| author | A. K., Arifah Hong, W. S. T. M. J., Azlina S., Nadzri Wai, Y. H. |
| author_facet | A. K., Arifah Hong, W. S. T. M. J., Azlina S., Nadzri Wai, Y. H. |
| author_sort | A. K., Arifah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Ketoprofen, meloxicam, celecoxib and rofecoxib were used in the present study to investigate the effects of NSAIDs on carrageenan-induced paw oedema in rats. Acute inflammation was induced by subplantar injection of carrageenan (0.1 ml, 1 % w/v) into the rat hind paw. Celecoxib (10 mg/kg) caused significant and prolong inhibition of rat paw oedema up to four hours. Treatment of rats with ketoprofen (1 mg/kg) significantly suppressed paw oedema volume at 2, 3 and 4 hour. Meloxicam at (0.2 mg/kg) also significantly inhibited paw oedema at first three hours. Rofecoxib (10 mg/kg) was only effective in inhibiting the paw oedema volume at 2 and 3 hours. |
| first_indexed | 2025-11-15T11:21:55Z |
| format | Conference or Workshop Item |
| id | upm-65116 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:21:55Z |
| publishDate | 2004 |
| publisher | Universiti Putra Malaysia Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-651162018-09-04T04:04:28Z http://psasir.upm.edu.my/id/eprint/65116/ The effect of non-steroidal anti-inflammatory drugs on carrageenan-induced paw oedema in rats A. K., Arifah Hong, W. S. T. M. J., Azlina S., Nadzri Wai, Y. H. Ketoprofen, meloxicam, celecoxib and rofecoxib were used in the present study to investigate the effects of NSAIDs on carrageenan-induced paw oedema in rats. Acute inflammation was induced by subplantar injection of carrageenan (0.1 ml, 1 % w/v) into the rat hind paw. Celecoxib (10 mg/kg) caused significant and prolong inhibition of rat paw oedema up to four hours. Treatment of rats with ketoprofen (1 mg/kg) significantly suppressed paw oedema volume at 2, 3 and 4 hour. Meloxicam at (0.2 mg/kg) also significantly inhibited paw oedema at first three hours. Rofecoxib (10 mg/kg) was only effective in inhibiting the paw oedema volume at 2 and 3 hours. Universiti Putra Malaysia Press 2004 Conference or Workshop Item PeerReviewed text en http://psasir.upm.edu.my/id/eprint/65116/1/71-32.pdf A. K., Arifah and Hong, W. S. T. and M. J., Azlina and S., Nadzri and Wai, Y. H. (2004) The effect of non-steroidal anti-inflammatory drugs on carrageenan-induced paw oedema in rats. In: 11th International Conference of the Association of Institutions for Tropical Veterinary Medicine and 16th Veterinary Association Malaysia Congress, 23-27 Aug. 2004, Sunway Pyramid Convention Centre, Petaling Jaya, Malaysia. (pp. 346-347). |
| spellingShingle | A. K., Arifah Hong, W. S. T. M. J., Azlina S., Nadzri Wai, Y. H. The effect of non-steroidal anti-inflammatory drugs on carrageenan-induced paw oedema in rats |
| title | The effect of non-steroidal anti-inflammatory drugs on carrageenan-induced paw oedema in rats |
| title_full | The effect of non-steroidal anti-inflammatory drugs on carrageenan-induced paw oedema in rats |
| title_fullStr | The effect of non-steroidal anti-inflammatory drugs on carrageenan-induced paw oedema in rats |
| title_full_unstemmed | The effect of non-steroidal anti-inflammatory drugs on carrageenan-induced paw oedema in rats |
| title_short | The effect of non-steroidal anti-inflammatory drugs on carrageenan-induced paw oedema in rats |
| title_sort | effect of non-steroidal anti-inflammatory drugs on carrageenan-induced paw oedema in rats |
| url | http://psasir.upm.edu.my/id/eprint/65116/ http://psasir.upm.edu.my/id/eprint/65116/1/71-32.pdf |