Regulation of bursa immune response by velogenic NDV
Newcastle disease virus (NDV) has been well characterised and classified. We have reported the differential regulation of cytokines/chemokines expression in spleen post-infected with genotype VII and VIII NDV. To further understand the regulation of adaptive immunity by these strains of NDV, we comp...
| Main Authors: | , , , , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
Faculty of Veterinary Medicine, Universiti Putra Malaysia
2015
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| Online Access: | http://psasir.upm.edu.my/id/eprint/65047/ http://psasir.upm.edu.my/id/eprint/65047/1/PA-46.pdf |
| _version_ | 1848855176562081792 |
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| author | Teo, Kristeen Ye Wen Yeap, Swee Keong Tan, Sheau Wei Omar, Abdul Rahman Ideris, Aini Tan, Soon Guan Mohammed Alitheen, Noorjahan Banu |
| author_facet | Teo, Kristeen Ye Wen Yeap, Swee Keong Tan, Sheau Wei Omar, Abdul Rahman Ideris, Aini Tan, Soon Guan Mohammed Alitheen, Noorjahan Banu |
| author_sort | Teo, Kristeen Ye Wen |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Newcastle disease virus (NDV) has been well characterised and classified. We have reported the differential regulation of cytokines/chemokines expression in spleen post-infected with genotype VII and VIII NDV. To further understand the regulation of adaptive immunity by these strains of NDV, we compared the viral load, cytokines expression and oxidative stress in bursa of infected chicken. Genotype VII IBS002 was recorded with higher viral load in bursa of infected chicken comparing to genotype VIII AF2240. Although both strains of NDV upregulated proinflammatory cytokines (IFN-ɣ, CXCLi2 and IL-18) expression and nitric oxide in bursa of infected chicken, level of upregulation was greater in the bursa of AF2240 infected chicken. These findings supporting the idea of acute infection by AF2240, which resulted to earlier mortality than chicken infected with IBS002. |
| first_indexed | 2025-11-15T11:21:36Z |
| format | Conference or Workshop Item |
| id | upm-65047 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:21:36Z |
| publishDate | 2015 |
| publisher | Faculty of Veterinary Medicine, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-650472018-09-03T04:49:26Z http://psasir.upm.edu.my/id/eprint/65047/ Regulation of bursa immune response by velogenic NDV Teo, Kristeen Ye Wen Yeap, Swee Keong Tan, Sheau Wei Omar, Abdul Rahman Ideris, Aini Tan, Soon Guan Mohammed Alitheen, Noorjahan Banu Newcastle disease virus (NDV) has been well characterised and classified. We have reported the differential regulation of cytokines/chemokines expression in spleen post-infected with genotype VII and VIII NDV. To further understand the regulation of adaptive immunity by these strains of NDV, we compared the viral load, cytokines expression and oxidative stress in bursa of infected chicken. Genotype VII IBS002 was recorded with higher viral load in bursa of infected chicken comparing to genotype VIII AF2240. Although both strains of NDV upregulated proinflammatory cytokines (IFN-ɣ, CXCLi2 and IL-18) expression and nitric oxide in bursa of infected chicken, level of upregulation was greater in the bursa of AF2240 infected chicken. These findings supporting the idea of acute infection by AF2240, which resulted to earlier mortality than chicken infected with IBS002. Faculty of Veterinary Medicine, Universiti Putra Malaysia 2015 Conference or Workshop Item PeerReviewed text en http://psasir.upm.edu.my/id/eprint/65047/1/PA-46.pdf Teo, Kristeen Ye Wen and Yeap, Swee Keong and Tan, Sheau Wei and Omar, Abdul Rahman and Ideris, Aini and Tan, Soon Guan and Mohammed Alitheen, Noorjahan Banu (2015) Regulation of bursa immune response by velogenic NDV. In: World Veterinary Poultry Association (Malaysia Branch) and World's Poultry Science Association (Malaysia Branch) Scientific Conference 2015, 21-22 Sept. 2015, Kuala Lumpur Convention Centre, Kuala Lumpur, Malaysia. (pp. 210-211). |
| spellingShingle | Teo, Kristeen Ye Wen Yeap, Swee Keong Tan, Sheau Wei Omar, Abdul Rahman Ideris, Aini Tan, Soon Guan Mohammed Alitheen, Noorjahan Banu Regulation of bursa immune response by velogenic NDV |
| title | Regulation of bursa immune response by velogenic NDV |
| title_full | Regulation of bursa immune response by velogenic NDV |
| title_fullStr | Regulation of bursa immune response by velogenic NDV |
| title_full_unstemmed | Regulation of bursa immune response by velogenic NDV |
| title_short | Regulation of bursa immune response by velogenic NDV |
| title_sort | regulation of bursa immune response by velogenic ndv |
| url | http://psasir.upm.edu.my/id/eprint/65047/ http://psasir.upm.edu.my/id/eprint/65047/1/PA-46.pdf |