Zerumbone alleviates neuropathic pain through the involvement of L-arginine-nitric oxide-cGMP-K+ ATP channel pathways in chronic constriction injury in mice model
The present study investigates the involvement of the l-arginine-Nitric Oxide-cGMP-K⁺ ATP pathways responsible for the action of anti-allodynic and antihyperalgesic activities of zerumbone in chronic constriction injury (CCI) induced neuropathic pain in mice. The role of l-arginine-NO-cGMP-K⁺ was as...
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| Format: | Article |
| Language: | English |
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MDPI
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/63742/ http://psasir.upm.edu.my/id/eprint/63742/1/Zerumbone%20Alleviates%20Neuropathic%20Pain%20through%20the.pdf |
| _version_ | 1848854858574069760 |
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| author | Zulazmi, Nurul Atiqah Gopalsamy, Banulata Chia, Jasmine Siew Min Farouk, Ahmad Akira Omar Sulaiman, Mohd Roslan Bharatham, B. Hemabarathy Perimal, Enoch Kumar |
| author_facet | Zulazmi, Nurul Atiqah Gopalsamy, Banulata Chia, Jasmine Siew Min Farouk, Ahmad Akira Omar Sulaiman, Mohd Roslan Bharatham, B. Hemabarathy Perimal, Enoch Kumar |
| author_sort | Zulazmi, Nurul Atiqah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The present study investigates the involvement of the l-arginine-Nitric Oxide-cGMP-K⁺ ATP pathways responsible for the action of anti-allodynic and antihyperalgesic activities of zerumbone in chronic constriction injury (CCI) induced neuropathic pain in mice. The role of l-arginine-NO-cGMP-K⁺ was assessed by the von Frey and the Randall-Selitto tests. Both allodynia and hyperalgesia assessments were carried out on the 14th day post CCI, 30 min after treatments were given for each respective pathway. Anti-allodynic and antihyperalgesic effects of zerumbone (10 mg/kg, i.p) were significantly reversed by the pre-treatment of l-arginine (10 mg/kg), 1H [1,2,4]Oxadiazole[4,3a]quinoxalin-1-one (ODQ), a soluble guanosyl cyclase blocker (2 mg/kg i.p.) and glibenclamide (ATP-sensitive potassium channel blocker) (10 mg/kg i.p.) (p < 0.05). Taken together, these results indicate that systemic administration of zerumbone produces significant anti-allodynic and antihyperalgesic activities in neuropathic pain in mice possibly due to involvement of the l-arginine-NO-cGMP-PKG-K⁺ ATP channel pathways in CCI model. |
| first_indexed | 2025-11-15T11:16:33Z |
| format | Article |
| id | upm-63742 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:16:33Z |
| publishDate | 2017 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-637422018-11-30T04:15:05Z http://psasir.upm.edu.my/id/eprint/63742/ Zerumbone alleviates neuropathic pain through the involvement of L-arginine-nitric oxide-cGMP-K+ ATP channel pathways in chronic constriction injury in mice model Zulazmi, Nurul Atiqah Gopalsamy, Banulata Chia, Jasmine Siew Min Farouk, Ahmad Akira Omar Sulaiman, Mohd Roslan Bharatham, B. Hemabarathy Perimal, Enoch Kumar The present study investigates the involvement of the l-arginine-Nitric Oxide-cGMP-K⁺ ATP pathways responsible for the action of anti-allodynic and antihyperalgesic activities of zerumbone in chronic constriction injury (CCI) induced neuropathic pain in mice. The role of l-arginine-NO-cGMP-K⁺ was assessed by the von Frey and the Randall-Selitto tests. Both allodynia and hyperalgesia assessments were carried out on the 14th day post CCI, 30 min after treatments were given for each respective pathway. Anti-allodynic and antihyperalgesic effects of zerumbone (10 mg/kg, i.p) were significantly reversed by the pre-treatment of l-arginine (10 mg/kg), 1H [1,2,4]Oxadiazole[4,3a]quinoxalin-1-one (ODQ), a soluble guanosyl cyclase blocker (2 mg/kg i.p.) and glibenclamide (ATP-sensitive potassium channel blocker) (10 mg/kg i.p.) (p < 0.05). Taken together, these results indicate that systemic administration of zerumbone produces significant anti-allodynic and antihyperalgesic activities in neuropathic pain in mice possibly due to involvement of the l-arginine-NO-cGMP-PKG-K⁺ ATP channel pathways in CCI model. MDPI 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/63742/1/Zerumbone%20Alleviates%20Neuropathic%20Pain%20through%20the.pdf Zulazmi, Nurul Atiqah and Gopalsamy, Banulata and Chia, Jasmine Siew Min and Farouk, Ahmad Akira Omar and Sulaiman, Mohd Roslan and Bharatham, B. Hemabarathy and Perimal, Enoch Kumar (2017) Zerumbone alleviates neuropathic pain through the involvement of L-arginine-nitric oxide-cGMP-K+ ATP channel pathways in chronic constriction injury in mice model. Molecules, 22 (4). art. no. 555. pp. 1-14. ISSN 1420-3049 10.3390/molecules22040555 |
| spellingShingle | Zulazmi, Nurul Atiqah Gopalsamy, Banulata Chia, Jasmine Siew Min Farouk, Ahmad Akira Omar Sulaiman, Mohd Roslan Bharatham, B. Hemabarathy Perimal, Enoch Kumar Zerumbone alleviates neuropathic pain through the involvement of L-arginine-nitric oxide-cGMP-K+ ATP channel pathways in chronic constriction injury in mice model |
| title | Zerumbone alleviates neuropathic pain through the involvement of L-arginine-nitric oxide-cGMP-K+ ATP channel pathways in chronic constriction injury in mice model |
| title_full | Zerumbone alleviates neuropathic pain through the involvement of L-arginine-nitric oxide-cGMP-K+ ATP channel pathways in chronic constriction injury in mice model |
| title_fullStr | Zerumbone alleviates neuropathic pain through the involvement of L-arginine-nitric oxide-cGMP-K+ ATP channel pathways in chronic constriction injury in mice model |
| title_full_unstemmed | Zerumbone alleviates neuropathic pain through the involvement of L-arginine-nitric oxide-cGMP-K+ ATP channel pathways in chronic constriction injury in mice model |
| title_short | Zerumbone alleviates neuropathic pain through the involvement of L-arginine-nitric oxide-cGMP-K+ ATP channel pathways in chronic constriction injury in mice model |
| title_sort | zerumbone alleviates neuropathic pain through the involvement of l-arginine-nitric oxide-cgmp-k+ atp channel pathways in chronic constriction injury in mice model |
| url | http://psasir.upm.edu.my/id/eprint/63742/ http://psasir.upm.edu.my/id/eprint/63742/ http://psasir.upm.edu.my/id/eprint/63742/1/Zerumbone%20Alleviates%20Neuropathic%20Pain%20through%20the.pdf |