Synthesis, Characterisation and Biological Activities of mixed-Ligand Copper(II) Complexes Containing Saccharin
New mixed-ligand copper(II) saccharinate complexes of HNNS Schiff bases of Smethyldithiocarbazate, S-benzyldithiocarbazate, S-2-picolyldithiocarbazate and S-4- picolyldithiocarbazate were synthesized by reacting [Cu( sa~)~(H~0)~] 'w2Hith~ Oth e appropriate Schiff bases in water-ethanol-metha...
| Main Author: | |
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| Format: | Thesis |
| Language: | English |
| Published: |
2005
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| Online Access: | http://psasir.upm.edu.my/id/eprint/6365/ http://psasir.upm.edu.my/id/eprint/6365/1/FPSK%28M%29_2005_21.pdf |
| _version_ | 1848840357209440256 |
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| author | Begum, Thahira |
| author_facet | Begum, Thahira |
| author_sort | Begum, Thahira |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | New mixed-ligand copper(II) saccharinate complexes of HNNS Schiff bases of Smethyldithiocarbazate,
S-benzyldithiocarbazate, S-2-picolyldithiocarbazate and S-4-
picolyldithiocarbazate were synthesized by reacting [Cu( sa~)~(H~0)~] 'w2Hith~ Oth e
appropriate Schiff bases in water-ethanol-methanol mixtures. These complexes were
characterized by elemental analysis, conductance, magnetic susceptibility, IR and
electronic spectroscopic measurements. Magnetic and spectral results for the complexes
support either a four or five-coordinate geometry in which the Schiff bases coordinate as
NNS tridentate ligands and the saccharinate anion coordinates as a unidentate N-donor
ligand. X-ray crystallographic structural analysis of the copper(I1)saccharinate complex
of S-methyl-~-N-(6-methylpyrid-2-yl)methylenedithiocarbazatesh ows that the complex
has a distorted square-pyramidal structure in which the Schiff base is coordinated to the
copper ion as a tridentate NNS chelating agent via the pyridine nitrogen atom, the
azomethine nitrogen atom and the tholate sulphur atom. The fourth and fifth
coordination positions of the five-coordinate Cu(I1) ion are occupied by the imino
nitrogen of the saccharinate anion and oxygen atom of the aqua ligand. X-ray
crystallographic structural analysis of the copper(I1)saccharinate complex of S-benzyl-0-
N-(2-acetylpyndyl)methylenedithiocarb~ shows that ths complex has a distorted
square-planar structure in whch the Schiff base is also coordinated to the copper ion as a
tridentate NNS chelating agent with the fourth coordination position of the fourcoordinate
Cu(II) ion being occupied by the imino nitrogen of the saccharinate anion. The
complexes have been evaluated for their biologcal activities against seven pathogenic
microbials and three cancer cell lines, KL-60 (Human myeloid leukemic cells), MCF-7
(Human breast carcinoma cells with positive estrogen receptor) and Caov-3 (Human
ovarian adenocarcinoma cancer cells). Most of the complexes exhibit marked
cytotoxicity against the cell lines and display moderate activity against pathogenic
bacteria and h g i . |
| first_indexed | 2025-11-15T07:26:03Z |
| format | Thesis |
| id | upm-6365 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T07:26:03Z |
| publishDate | 2005 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-63652023-10-25T04:42:42Z http://psasir.upm.edu.my/id/eprint/6365/ Synthesis, Characterisation and Biological Activities of mixed-Ligand Copper(II) Complexes Containing Saccharin Begum, Thahira New mixed-ligand copper(II) saccharinate complexes of HNNS Schiff bases of Smethyldithiocarbazate, S-benzyldithiocarbazate, S-2-picolyldithiocarbazate and S-4- picolyldithiocarbazate were synthesized by reacting [Cu( sa~)~(H~0)~] 'w2Hith~ Oth e appropriate Schiff bases in water-ethanol-methanol mixtures. These complexes were characterized by elemental analysis, conductance, magnetic susceptibility, IR and electronic spectroscopic measurements. Magnetic and spectral results for the complexes support either a four or five-coordinate geometry in which the Schiff bases coordinate as NNS tridentate ligands and the saccharinate anion coordinates as a unidentate N-donor ligand. X-ray crystallographic structural analysis of the copper(I1)saccharinate complex of S-methyl-~-N-(6-methylpyrid-2-yl)methylenedithiocarbazatesh ows that the complex has a distorted square-pyramidal structure in which the Schiff base is coordinated to the copper ion as a tridentate NNS chelating agent via the pyridine nitrogen atom, the azomethine nitrogen atom and the tholate sulphur atom. The fourth and fifth coordination positions of the five-coordinate Cu(I1) ion are occupied by the imino nitrogen of the saccharinate anion and oxygen atom of the aqua ligand. X-ray crystallographic structural analysis of the copper(I1)saccharinate complex of S-benzyl-0- N-(2-acetylpyndyl)methylenedithiocarb~ shows that ths complex has a distorted square-planar structure in whch the Schiff base is also coordinated to the copper ion as a tridentate NNS chelating agent with the fourth coordination position of the fourcoordinate Cu(II) ion being occupied by the imino nitrogen of the saccharinate anion. The complexes have been evaluated for their biologcal activities against seven pathogenic microbials and three cancer cell lines, KL-60 (Human myeloid leukemic cells), MCF-7 (Human breast carcinoma cells with positive estrogen receptor) and Caov-3 (Human ovarian adenocarcinoma cancer cells). Most of the complexes exhibit marked cytotoxicity against the cell lines and display moderate activity against pathogenic bacteria and h g i . 2005-02 Thesis NonPeerReviewed text en http://psasir.upm.edu.my/id/eprint/6365/1/FPSK%28M%29_2005_21.pdf Begum, Thahira (2005) Synthesis, Characterisation and Biological Activities of mixed-Ligand Copper(II) Complexes Containing Saccharin. Masters thesis, Universiti Putra Malaysia. |
| spellingShingle | Begum, Thahira Synthesis, Characterisation and Biological Activities of mixed-Ligand Copper(II) Complexes Containing Saccharin |
| title | Synthesis, Characterisation and Biological Activities of mixed-Ligand Copper(II) Complexes Containing Saccharin |
| title_full | Synthesis, Characterisation and Biological Activities of mixed-Ligand Copper(II) Complexes Containing Saccharin |
| title_fullStr | Synthesis, Characterisation and Biological Activities of mixed-Ligand Copper(II) Complexes Containing Saccharin |
| title_full_unstemmed | Synthesis, Characterisation and Biological Activities of mixed-Ligand Copper(II) Complexes Containing Saccharin |
| title_short | Synthesis, Characterisation and Biological Activities of mixed-Ligand Copper(II) Complexes Containing Saccharin |
| title_sort | synthesis, characterisation and biological activities of mixed-ligand copper(ii) complexes containing saccharin |
| url | http://psasir.upm.edu.my/id/eprint/6365/ http://psasir.upm.edu.my/id/eprint/6365/1/FPSK%28M%29_2005_21.pdf |