The synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications
Minerals substituted apatite (M-HA) nanoparticles were prepared by the precipitation of minerals and phosphate reactants in choline chloride-Thiourea (ChCl–TU) deep eutectic solvent (DESs) as a facile and green way approach. After preparation of nanoparticles (F-M-HA (F = Fresh solvent)), the DESs w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/63534/ http://psasir.upm.edu.my/id/eprint/63534/1/The%20synthesis%2C%20characterization%20and%20in%20vivo%20study%20of%20mineral%20substituted%20hydroxyapatite%20for%20prospective%20bone%20tissue%20rejuvenation%20applications.pdf |
| _version_ | 1848854811621982208 |
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| author | Govindaraj, Dharman Rajan, Mariappan Munusamy, Murugan A. Alarfaj, Abdullah A. Sadasivuni, Kishor Kumar Kumar, S. Suresh |
| author_facet | Govindaraj, Dharman Rajan, Mariappan Munusamy, Murugan A. Alarfaj, Abdullah A. Sadasivuni, Kishor Kumar Kumar, S. Suresh |
| author_sort | Govindaraj, Dharman |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Minerals substituted apatite (M-HA) nanoparticles were prepared by the precipitation of minerals and phosphate reactants in choline chloride-Thiourea (ChCl–TU) deep eutectic solvent (DESs) as a facile and green way approach. After preparation of nanoparticles (F-M-HA (F = Fresh solvent)), the DESs was recovered productively and reprocess for the preparation of R-M-HA nanoparticles (R = Recycle solvent).The functional groups, phase, surface texture and the elemental composition of the M-HA nanoparticles were evaluated by advance characterization methods. The physicochemical results of the current work authoritative the successful uses of the novel (ChCl–TU) DESs as eco-friendly recuperate and give the medium for the preparation of M-HA nanoparticles. Moreover, the as-synthesized both M-HA nanoparticles exhibit excellent biocompatibility, consisting of cell co-cultivation and cell adhesion, in vivo according to surgical implantation of Wistar rats. |
| first_indexed | 2025-11-15T11:15:48Z |
| format | Article |
| id | upm-63534 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:15:48Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-635342018-11-05T00:00:57Z http://psasir.upm.edu.my/id/eprint/63534/ The synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications Govindaraj, Dharman Rajan, Mariappan Munusamy, Murugan A. Alarfaj, Abdullah A. Sadasivuni, Kishor Kumar Kumar, S. Suresh Minerals substituted apatite (M-HA) nanoparticles were prepared by the precipitation of minerals and phosphate reactants in choline chloride-Thiourea (ChCl–TU) deep eutectic solvent (DESs) as a facile and green way approach. After preparation of nanoparticles (F-M-HA (F = Fresh solvent)), the DESs was recovered productively and reprocess for the preparation of R-M-HA nanoparticles (R = Recycle solvent).The functional groups, phase, surface texture and the elemental composition of the M-HA nanoparticles were evaluated by advance characterization methods. The physicochemical results of the current work authoritative the successful uses of the novel (ChCl–TU) DESs as eco-friendly recuperate and give the medium for the preparation of M-HA nanoparticles. Moreover, the as-synthesized both M-HA nanoparticles exhibit excellent biocompatibility, consisting of cell co-cultivation and cell adhesion, in vivo according to surgical implantation of Wistar rats. Elsevier 2017-11 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/63534/1/The%20synthesis%2C%20characterization%20and%20in%20vivo%20study%20of%20mineral%20substituted%20hydroxyapatite%20for%20prospective%20bone%20tissue%20rejuvenation%20applications.pdf Govindaraj, Dharman and Rajan, Mariappan and Munusamy, Murugan A. and Alarfaj, Abdullah A. and Sadasivuni, Kishor Kumar and Kumar, S. Suresh (2017) The synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications. Nanomedicine: Nanotechnology Biology and Medicine, 13 (8). 2661 - 2669. ISSN 1549-9634 https://www.sciencedirect.com/science/article/pii/S1549963417301478?via%3Dihub 10.1016/j.nano.2017.07.017 |
| spellingShingle | Govindaraj, Dharman Rajan, Mariappan Munusamy, Murugan A. Alarfaj, Abdullah A. Sadasivuni, Kishor Kumar Kumar, S. Suresh The synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications |
| title | The synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications |
| title_full | The synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications |
| title_fullStr | The synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications |
| title_full_unstemmed | The synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications |
| title_short | The synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications |
| title_sort | synthesis, characterization and in vivo study of mineral substituted hydroxyapatite for prospective bone tissue rejuvenation applications |
| url | http://psasir.upm.edu.my/id/eprint/63534/ http://psasir.upm.edu.my/id/eprint/63534/ http://psasir.upm.edu.my/id/eprint/63534/ http://psasir.upm.edu.my/id/eprint/63534/1/The%20synthesis%2C%20characterization%20and%20in%20vivo%20study%20of%20mineral%20substituted%20hydroxyapatite%20for%20prospective%20bone%20tissue%20rejuvenation%20applications.pdf |