The CRISPR growth spurt: from bench to clinic on versatile small RNAs
Clustered Regulatory Interspaced Short Palindromic Repeats (CRISPR) in association with CRISPR associated protein (Cas) is an adaptive immune system, playing a pivotal role in the defense of bacteria and archaea. Ease of handling and cost effectiveness make CRISPR-Cas system an ideal programmable nu...
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| Format: | Article |
| Language: | English |
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Korean Society for Microbiology and Biotechnology
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/63418/ http://psasir.upm.edu.my/id/eprint/63418/1/The%20CRISPR%20growth%20spurt%20from%20bench%20to%20clinic%20on%20versatile%20small%20RNAs.pdf |
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| author | Bayat, Hadi Omidi, Meisam Masoumeh, Rajabibazl Rahimpour, Azam Sabri, Suriana |
| author_facet | Bayat, Hadi Omidi, Meisam Masoumeh, Rajabibazl Rahimpour, Azam Sabri, Suriana |
| author_sort | Bayat, Hadi |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Clustered Regulatory Interspaced Short Palindromic Repeats (CRISPR) in association with CRISPR associated protein (Cas) is an adaptive immune system, playing a pivotal role in the defense of bacteria and archaea. Ease of handling and cost effectiveness make CRISPR-Cas system an ideal programmable nuclease tool. Recent advances in understanding the CRISPR-Cas system have tremendously improved its efficiency. For instance, it is possible to recapitulate the chronicle CRISPR-Cas from its infancy and inaugurate a developed version by generating novel variants of Cas proteins, subduing off-target effects and optimization of innovative strategies. In summary, CRISPR-Cas system could be employed in a number of applications including providing model systems, rectification of detrimental mutations, and antiviral therapies. |
| first_indexed | 2025-11-15T11:15:21Z |
| format | Article |
| id | upm-63418 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:15:21Z |
| publishDate | 2017 |
| publisher | Korean Society for Microbiology and Biotechnology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-634182018-07-19T02:18:27Z http://psasir.upm.edu.my/id/eprint/63418/ The CRISPR growth spurt: from bench to clinic on versatile small RNAs Bayat, Hadi Omidi, Meisam Masoumeh, Rajabibazl Rahimpour, Azam Sabri, Suriana Clustered Regulatory Interspaced Short Palindromic Repeats (CRISPR) in association with CRISPR associated protein (Cas) is an adaptive immune system, playing a pivotal role in the defense of bacteria and archaea. Ease of handling and cost effectiveness make CRISPR-Cas system an ideal programmable nuclease tool. Recent advances in understanding the CRISPR-Cas system have tremendously improved its efficiency. For instance, it is possible to recapitulate the chronicle CRISPR-Cas from its infancy and inaugurate a developed version by generating novel variants of Cas proteins, subduing off-target effects and optimization of innovative strategies. In summary, CRISPR-Cas system could be employed in a number of applications including providing model systems, rectification of detrimental mutations, and antiviral therapies. Korean Society for Microbiology and Biotechnology 2017-02 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/63418/1/The%20CRISPR%20growth%20spurt%20from%20bench%20to%20clinic%20on%20versatile%20small%20RNAs.pdf Bayat, Hadi and Omidi, Meisam and Masoumeh, Rajabibazl and Rahimpour, Azam and Sabri, Suriana (2017) The CRISPR growth spurt: from bench to clinic on versatile small RNAs. Journal of Microbiology and Biotechnology, 27 (2). pp. 207-218. ISSN 1017-7825; ESSN: 1738-8872 http://www.jmb.or.kr/ 10.4014/jmb.1607.07005 |
| spellingShingle | Bayat, Hadi Omidi, Meisam Masoumeh, Rajabibazl Rahimpour, Azam Sabri, Suriana The CRISPR growth spurt: from bench to clinic on versatile small RNAs |
| title | The CRISPR growth spurt: from bench to clinic on versatile small RNAs |
| title_full | The CRISPR growth spurt: from bench to clinic on versatile small RNAs |
| title_fullStr | The CRISPR growth spurt: from bench to clinic on versatile small RNAs |
| title_full_unstemmed | The CRISPR growth spurt: from bench to clinic on versatile small RNAs |
| title_short | The CRISPR growth spurt: from bench to clinic on versatile small RNAs |
| title_sort | crispr growth spurt: from bench to clinic on versatile small rnas |
| url | http://psasir.upm.edu.my/id/eprint/63418/ http://psasir.upm.edu.my/id/eprint/63418/ http://psasir.upm.edu.my/id/eprint/63418/ http://psasir.upm.edu.my/id/eprint/63418/1/The%20CRISPR%20growth%20spurt%20from%20bench%20to%20clinic%20on%20versatile%20small%20RNAs.pdf |