Stem cell therapies for reversing vision loss
Current clinical trials that evaluate human pluripotent stem cell (hPSC)-based therapies predominantly target treating macular degeneration of the eyes because the eye is an isolated tissue that is naturally weakly immunogenic. Here, we discuss current bioengineering approaches and biomaterial usage...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Cell Press
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/63289/ http://psasir.upm.edu.my/id/eprint/63289/1/Stem%20cell%20therapies%20for%20reversing%20vision%20loss.pdf |
| _version_ | 1848854755806281728 |
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| author | Higuchi, Akon Kumar, S. Suresh Benelli, Giovanni Alarfaj, Abdullah A. Munusamy, Murugan A. Umezawa, Akihiko Murugan, Kadarkarai |
| author_facet | Higuchi, Akon Kumar, S. Suresh Benelli, Giovanni Alarfaj, Abdullah A. Munusamy, Murugan A. Umezawa, Akihiko Murugan, Kadarkarai |
| author_sort | Higuchi, Akon |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Current clinical trials that evaluate human pluripotent stem cell (hPSC)-based therapies predominantly target treating macular degeneration of the eyes because the eye is an isolated tissue that is naturally weakly immunogenic. Here, we discuss current bioengineering approaches and biomaterial usage in combination with stem cell therapy for macular degeneration disease treatment. Retinal pigment epithelium (RPE) differentiated from hPSCs is typically used in most clinical trials for treating patients, whereas bone marrow mononuclear cells (BMNCs) or mesenchymal stem cells (MSCs) are intravitreally transplanted, undifferentiated, into patient eyes. We also discuss reported negative effects of stem cell therapy, such as patients becoming blind following transplantation of adipose-derived stem cells, which are increasingly used by 'stem-cell clinics'. |
| first_indexed | 2025-11-15T11:14:55Z |
| format | Article |
| id | upm-63289 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:14:55Z |
| publishDate | 2017 |
| publisher | Cell Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-632892018-09-26T01:50:19Z http://psasir.upm.edu.my/id/eprint/63289/ Stem cell therapies for reversing vision loss Higuchi, Akon Kumar, S. Suresh Benelli, Giovanni Alarfaj, Abdullah A. Munusamy, Murugan A. Umezawa, Akihiko Murugan, Kadarkarai Current clinical trials that evaluate human pluripotent stem cell (hPSC)-based therapies predominantly target treating macular degeneration of the eyes because the eye is an isolated tissue that is naturally weakly immunogenic. Here, we discuss current bioengineering approaches and biomaterial usage in combination with stem cell therapy for macular degeneration disease treatment. Retinal pigment epithelium (RPE) differentiated from hPSCs is typically used in most clinical trials for treating patients, whereas bone marrow mononuclear cells (BMNCs) or mesenchymal stem cells (MSCs) are intravitreally transplanted, undifferentiated, into patient eyes. We also discuss reported negative effects of stem cell therapy, such as patients becoming blind following transplantation of adipose-derived stem cells, which are increasingly used by 'stem-cell clinics'. Cell Press 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/63289/1/Stem%20cell%20therapies%20for%20reversing%20vision%20loss.pdf Higuchi, Akon and Kumar, S. Suresh and Benelli, Giovanni and Alarfaj, Abdullah A. and Munusamy, Murugan A. and Umezawa, Akihiko and Murugan, Kadarkarai (2017) Stem cell therapies for reversing vision loss. Trends in Biotechnology, 35 (11). 1102 - 1117. ISSN 0167-7799; ESSN: 1879-3096 |
| spellingShingle | Higuchi, Akon Kumar, S. Suresh Benelli, Giovanni Alarfaj, Abdullah A. Munusamy, Murugan A. Umezawa, Akihiko Murugan, Kadarkarai Stem cell therapies for reversing vision loss |
| title | Stem cell therapies for reversing vision loss |
| title_full | Stem cell therapies for reversing vision loss |
| title_fullStr | Stem cell therapies for reversing vision loss |
| title_full_unstemmed | Stem cell therapies for reversing vision loss |
| title_short | Stem cell therapies for reversing vision loss |
| title_sort | stem cell therapies for reversing vision loss |
| url | http://psasir.upm.edu.my/id/eprint/63289/ http://psasir.upm.edu.my/id/eprint/63289/1/Stem%20cell%20therapies%20for%20reversing%20vision%20loss.pdf |