Single step encapsulation process of tamoxifen in biodegradable polymer using supercritical anti-solvent (SAS) process
Tamoxifen is an anti-estrogen drug which has shown tremendous excellent recovery rate in breast cancer treatment. However, after a long term of consumption, patients are prone to experience side effects of tamoxifen. These side effects however can be reduced in controlled drug delivery, using encaps...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/63226/ http://psasir.upm.edu.my/id/eprint/63226/1/Single%20step%20encapsulation%20process%20of%20tamoxifen%20in%20biodegradable%20polymer%20using%20.pdf |
| _version_ | 1848854740942716928 |
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| author | Alias, Dalila Yunus, Robiah Chong, Gun Hean Che Abdullah, Che Azurahanim |
| author_facet | Alias, Dalila Yunus, Robiah Chong, Gun Hean Che Abdullah, Che Azurahanim |
| author_sort | Alias, Dalila |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Tamoxifen is an anti-estrogen drug which has shown tremendous excellent recovery rate in breast cancer treatment. However, after a long term of consumption, patients are prone to experience side effects of tamoxifen. These side effects however can be reduced in controlled drug delivery, using encapsulation within biodegradable method. Supercritical anti-solvent (SAS) process was chosen to synthesize tamoxifen encapsulated in poly-l-lactic using supercritical carbon dioxide as the anti-solvent. Conventionally, this encapsulation was carried out using processes such as solvent evaporation, spray drying and high pressure homogenization process. In SAS process, only a single step precipitation process was required to produce encapsulated particles and particles can be directly used upon process completion. Techniques such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), and energy dispersive x-ray analysis (EDX) were used to characterize the powder from SAS process and compared with raw tamoxifen as a reference. It was noted crystallinity of tamoxifen changes from crystalline to amorphous due to rapid precipitation process, but thermal properties such as melting point of tamoxifen retains after SAS process. From EDX analysis, it was found that no trace of solvent existed in the final product, thus indicating solvent was completely removed from the final product of SAS process. |
| first_indexed | 2025-11-15T11:14:41Z |
| format | Article |
| id | upm-63226 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T11:14:41Z |
| publishDate | 2017 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-632262018-09-26T01:46:19Z http://psasir.upm.edu.my/id/eprint/63226/ Single step encapsulation process of tamoxifen in biodegradable polymer using supercritical anti-solvent (SAS) process Alias, Dalila Yunus, Robiah Chong, Gun Hean Che Abdullah, Che Azurahanim Tamoxifen is an anti-estrogen drug which has shown tremendous excellent recovery rate in breast cancer treatment. However, after a long term of consumption, patients are prone to experience side effects of tamoxifen. These side effects however can be reduced in controlled drug delivery, using encapsulation within biodegradable method. Supercritical anti-solvent (SAS) process was chosen to synthesize tamoxifen encapsulated in poly-l-lactic using supercritical carbon dioxide as the anti-solvent. Conventionally, this encapsulation was carried out using processes such as solvent evaporation, spray drying and high pressure homogenization process. In SAS process, only a single step precipitation process was required to produce encapsulated particles and particles can be directly used upon process completion. Techniques such as Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), and energy dispersive x-ray analysis (EDX) were used to characterize the powder from SAS process and compared with raw tamoxifen as a reference. It was noted crystallinity of tamoxifen changes from crystalline to amorphous due to rapid precipitation process, but thermal properties such as melting point of tamoxifen retains after SAS process. From EDX analysis, it was found that no trace of solvent existed in the final product, thus indicating solvent was completely removed from the final product of SAS process. Elsevier 2017 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/63226/1/Single%20step%20encapsulation%20process%20of%20tamoxifen%20in%20biodegradable%20polymer%20using%20.pdf Alias, Dalila and Yunus, Robiah and Chong, Gun Hean and Che Abdullah, Che Azurahanim (2017) Single step encapsulation process of tamoxifen in biodegradable polymer using supercritical anti-solvent (SAS) process. Powder Technology, 309. 89 - 94. ISSN 0032-5910; ESSN: 1873-328X 10.1016/j.powtec.2016.12.039 |
| spellingShingle | Alias, Dalila Yunus, Robiah Chong, Gun Hean Che Abdullah, Che Azurahanim Single step encapsulation process of tamoxifen in biodegradable polymer using supercritical anti-solvent (SAS) process |
| title | Single step encapsulation process of tamoxifen in biodegradable polymer using supercritical anti-solvent (SAS) process |
| title_full | Single step encapsulation process of tamoxifen in biodegradable polymer using supercritical anti-solvent (SAS) process |
| title_fullStr | Single step encapsulation process of tamoxifen in biodegradable polymer using supercritical anti-solvent (SAS) process |
| title_full_unstemmed | Single step encapsulation process of tamoxifen in biodegradable polymer using supercritical anti-solvent (SAS) process |
| title_short | Single step encapsulation process of tamoxifen in biodegradable polymer using supercritical anti-solvent (SAS) process |
| title_sort | single step encapsulation process of tamoxifen in biodegradable polymer using supercritical anti-solvent (sas) process |
| url | http://psasir.upm.edu.my/id/eprint/63226/ http://psasir.upm.edu.my/id/eprint/63226/ http://psasir.upm.edu.my/id/eprint/63226/1/Single%20step%20encapsulation%20process%20of%20tamoxifen%20in%20biodegradable%20polymer%20using%20.pdf |