Primary sinonasal mucosal melanoma – a diagnostic and histological conundrum
Primary sinonasal mucosal melanomas (PSMM), a rare subtype of melanomas offers significant diagnostic challenge clinically and histologically especially when amelanotic, as they can show many histologic mimics that require immunohistochemical and molecular studies to confirm the diagnosis. We report...
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| Format: | Article |
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Ministry of Health, Brunei Darussalam
2017
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| Online Access: | http://psasir.upm.edu.my/id/eprint/62858/ |
| _version_ | 1848854678901620736 |
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| author | Bakrin, Ikmal Hisyam Liew, Kong Yew Mahayidin, Hasni Abu Hasan, Hasyma Doi, Mohamad |
| author_facet | Bakrin, Ikmal Hisyam Liew, Kong Yew Mahayidin, Hasni Abu Hasan, Hasyma Doi, Mohamad |
| author_sort | Bakrin, Ikmal Hisyam |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Primary sinonasal mucosal melanomas (PSMM), a rare subtype of melanomas offers significant diagnostic challenge clinically and histologically especially when amelanotic, as they can show many histologic mimics that require immunohistochemical and molecular studies to confirm the diagnosis. We report the case of a 50-year-old male presented with persistent left nasal blockage and epistaxis secondary to a fleshy and friable lobulated mass occupying the left nasal cavity and nasopharynx. The tumour was excised endoscopically and histology confirmed a malignant tumour consisting of small round blue cells with hyperchromatic nuclei, in solid sheets with areas of angiocentric pattern (H & E staining). The cells were positive for S100 protein and focally positive for HMB-45 and Melan A and a diagnosis of PSMM was made. However, he defaulted the subsequent radiotherapy and presented back a few months later with tumour recurrence locally and nodes metastasis. Despite undergoing radiotherapy, he died after two cycles due to an episode of acute coronary syndrome. |
| first_indexed | 2025-11-15T11:13:41Z |
| format | Article |
| id | upm-62858 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T11:13:41Z |
| publishDate | 2017 |
| publisher | Ministry of Health, Brunei Darussalam |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-628582022-11-23T00:00:33Z http://psasir.upm.edu.my/id/eprint/62858/ Primary sinonasal mucosal melanoma – a diagnostic and histological conundrum Bakrin, Ikmal Hisyam Liew, Kong Yew Mahayidin, Hasni Abu Hasan, Hasyma Doi, Mohamad Primary sinonasal mucosal melanomas (PSMM), a rare subtype of melanomas offers significant diagnostic challenge clinically and histologically especially when amelanotic, as they can show many histologic mimics that require immunohistochemical and molecular studies to confirm the diagnosis. We report the case of a 50-year-old male presented with persistent left nasal blockage and epistaxis secondary to a fleshy and friable lobulated mass occupying the left nasal cavity and nasopharynx. The tumour was excised endoscopically and histology confirmed a malignant tumour consisting of small round blue cells with hyperchromatic nuclei, in solid sheets with areas of angiocentric pattern (H & E staining). The cells were positive for S100 protein and focally positive for HMB-45 and Melan A and a diagnosis of PSMM was made. However, he defaulted the subsequent radiotherapy and presented back a few months later with tumour recurrence locally and nodes metastasis. Despite undergoing radiotherapy, he died after two cycles due to an episode of acute coronary syndrome. Ministry of Health, Brunei Darussalam 2017-01 Article PeerReviewed Bakrin, Ikmal Hisyam and Liew, Kong Yew and Mahayidin, Hasni and Abu Hasan, Hasyma and Doi, Mohamad (2017) Primary sinonasal mucosal melanoma – a diagnostic and histological conundrum. Brunei International Medical Journal, 13 (5). 173 - 177. ISSN 1560-5876; ESSN: 2079-3146 http://www.bimjonline.com/Past%20Issues/pastissues.htm |
| spellingShingle | Bakrin, Ikmal Hisyam Liew, Kong Yew Mahayidin, Hasni Abu Hasan, Hasyma Doi, Mohamad Primary sinonasal mucosal melanoma – a diagnostic and histological conundrum |
| title | Primary sinonasal mucosal melanoma – a diagnostic and histological conundrum |
| title_full | Primary sinonasal mucosal melanoma – a diagnostic and histological conundrum |
| title_fullStr | Primary sinonasal mucosal melanoma – a diagnostic and histological conundrum |
| title_full_unstemmed | Primary sinonasal mucosal melanoma – a diagnostic and histological conundrum |
| title_short | Primary sinonasal mucosal melanoma – a diagnostic and histological conundrum |
| title_sort | primary sinonasal mucosal melanoma – a diagnostic and histological conundrum |
| url | http://psasir.upm.edu.my/id/eprint/62858/ http://psasir.upm.edu.my/id/eprint/62858/ |