Ultrastructural pathology of the upper respiratory tract of rabbits experimentally infected with Pasteurella multocida A:3
Twenty-four 8 to 9 week-old Pasteurella multocida-free rabbits were divided into three equal groups, the first group was pretreated with hydrocortisone and inoculated intranasally with pasteurella multocida serotype A:3. The second group was inoculated intranasally with P. multocida without hydroc...
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| Format: | Article |
| Language: | English English |
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1999 Harcourt Publishers Limited
1999
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| Online Access: | http://psasir.upm.edu.my/id/eprint/6254/ http://psasir.upm.edu.my/id/eprint/6254/1/Ultrastructural%20pathology%20of%20the%20upper%20respiratory%20tract%20of%20rabbits%20experimentally%20infected%20with%20Pasteurella%20multocida%20A.pdf |
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| author | M. H., Al-Haddawi Sabri, Jasni Saad , Mohd Zamri Mutalib, Abdul Rahim Abdul Rahman, Sheikh Omar |
| author_facet | M. H., Al-Haddawi Sabri, Jasni Saad , Mohd Zamri Mutalib, Abdul Rahim Abdul Rahman, Sheikh Omar |
| author_sort | M. H., Al-Haddawi |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Twenty-four 8 to 9 week-old Pasteurella multocida-free rabbits were divided into three equal groups, the first group was pretreated
with hydrocortisone and inoculated intranasally with pasteurella multocida serotype A:3. The second group was inoculated
intranasally with P. multocida without hydrocortisone treatment. The third group was inoculated with phosphate buffered saline
only and used as a control group. Pasteurella multocida was isolated from the nasal cavity of all infected rabbits in group 1 and 2
and from the trachea of seven rabbits in group 1 and five rabbits in group 2. This study was conducted to observe the ultrastructural
changes of the upper respiratory tract of hydrocortisone treated and non-treated rabbits infected with P. multocida serotype A:3. The
ultrastructural changes detected in infected rabbits were ciliary destruction and deciliation of the ciliated epithelial cells, cellular swelling, goblet cell hyperplasia and endothelial cell damage. Pasteurella multocida was observed attached to the degenerated cilia,microvilli and mucus. Pasteurella multocida infection was associated with inflammatory responses, which may have caused tissue damage. It is possible that hydrocortisone modulates the severity of infection as an immune suppressor and an inhibitor of goblet cell secretion. |
| first_indexed | 2025-11-15T07:25:35Z |
| format | Article |
| id | upm-6254 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T07:25:35Z |
| publishDate | 1999 |
| publisher | 1999 Harcourt Publishers Limited |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-62542015-10-26T04:14:05Z http://psasir.upm.edu.my/id/eprint/6254/ Ultrastructural pathology of the upper respiratory tract of rabbits experimentally infected with Pasteurella multocida A:3 M. H., Al-Haddawi Sabri, Jasni Saad , Mohd Zamri Mutalib, Abdul Rahim Abdul Rahman, Sheikh Omar Twenty-four 8 to 9 week-old Pasteurella multocida-free rabbits were divided into three equal groups, the first group was pretreated with hydrocortisone and inoculated intranasally with pasteurella multocida serotype A:3. The second group was inoculated intranasally with P. multocida without hydrocortisone treatment. The third group was inoculated with phosphate buffered saline only and used as a control group. Pasteurella multocida was isolated from the nasal cavity of all infected rabbits in group 1 and 2 and from the trachea of seven rabbits in group 1 and five rabbits in group 2. This study was conducted to observe the ultrastructural changes of the upper respiratory tract of hydrocortisone treated and non-treated rabbits infected with P. multocida serotype A:3. The ultrastructural changes detected in infected rabbits were ciliary destruction and deciliation of the ciliated epithelial cells, cellular swelling, goblet cell hyperplasia and endothelial cell damage. Pasteurella multocida was observed attached to the degenerated cilia,microvilli and mucus. Pasteurella multocida infection was associated with inflammatory responses, which may have caused tissue damage. It is possible that hydrocortisone modulates the severity of infection as an immune suppressor and an inhibitor of goblet cell secretion. 1999 Harcourt Publishers Limited 1999-10 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/6254/1/Ultrastructural%20pathology%20of%20the%20upper%20respiratory%20tract%20of%20rabbits%20experimentally%20infected%20with%20Pasteurella%20multocida%20A.pdf M. H., Al-Haddawi and Sabri, Jasni and Saad , Mohd Zamri and Mutalib, Abdul Rahim and Abdul Rahman, Sheikh Omar (1999) Ultrastructural pathology of the upper respiratory tract of rabbits experimentally infected with Pasteurella multocida A:3. Research in Veterinary Science, 67 (2). pp. 161-168. ISSN 0034-5288 http://dx.doi.org/10.1053/rvsc.1998.0299 English |
| spellingShingle | M. H., Al-Haddawi Sabri, Jasni Saad , Mohd Zamri Mutalib, Abdul Rahim Abdul Rahman, Sheikh Omar Ultrastructural pathology of the upper respiratory tract of rabbits experimentally infected with Pasteurella multocida A:3 |
| title | Ultrastructural pathology of the upper respiratory tract of
rabbits experimentally infected with Pasteurella multocida A:3 |
| title_full | Ultrastructural pathology of the upper respiratory tract of
rabbits experimentally infected with Pasteurella multocida A:3 |
| title_fullStr | Ultrastructural pathology of the upper respiratory tract of
rabbits experimentally infected with Pasteurella multocida A:3 |
| title_full_unstemmed | Ultrastructural pathology of the upper respiratory tract of
rabbits experimentally infected with Pasteurella multocida A:3 |
| title_short | Ultrastructural pathology of the upper respiratory tract of
rabbits experimentally infected with Pasteurella multocida A:3 |
| title_sort | ultrastructural pathology of the upper respiratory tract of
rabbits experimentally infected with pasteurella multocida a:3 |
| url | http://psasir.upm.edu.my/id/eprint/6254/ http://psasir.upm.edu.my/id/eprint/6254/ http://psasir.upm.edu.my/id/eprint/6254/1/Ultrastructural%20pathology%20of%20the%20upper%20respiratory%20tract%20of%20rabbits%20experimentally%20infected%20with%20Pasteurella%20multocida%20A.pdf |