Ultrastructural pathology of the upper respiratory tract of rabbits experimentally infected with Pasteurella multocida A:3
Twenty-four 8 to 9 week-old Pasteurella multocida-free rabbits were divided into three equal groups, the first group was pretreated with hydrocortisone and inoculated intranasally with pasteurella multocida serotype A:3. The second group was inoculated intranasally with P. multocida without hydroc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
1999 Harcourt Publishers Limited
1999
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| Online Access: | http://psasir.upm.edu.my/id/eprint/6254/ http://psasir.upm.edu.my/id/eprint/6254/1/Ultrastructural%20pathology%20of%20the%20upper%20respiratory%20tract%20of%20rabbits%20experimentally%20infected%20with%20Pasteurella%20multocida%20A.pdf |
| Summary: | Twenty-four 8 to 9 week-old Pasteurella multocida-free rabbits were divided into three equal groups, the first group was pretreated
with hydrocortisone and inoculated intranasally with pasteurella multocida serotype A:3. The second group was inoculated
intranasally with P. multocida without hydrocortisone treatment. The third group was inoculated with phosphate buffered saline
only and used as a control group. Pasteurella multocida was isolated from the nasal cavity of all infected rabbits in group 1 and 2
and from the trachea of seven rabbits in group 1 and five rabbits in group 2. This study was conducted to observe the ultrastructural
changes of the upper respiratory tract of hydrocortisone treated and non-treated rabbits infected with P. multocida serotype A:3. The
ultrastructural changes detected in infected rabbits were ciliary destruction and deciliation of the ciliated epithelial cells, cellular swelling, goblet cell hyperplasia and endothelial cell damage. Pasteurella multocida was observed attached to the degenerated cilia,microvilli and mucus. Pasteurella multocida infection was associated with inflammatory responses, which may have caused tissue damage. It is possible that hydrocortisone modulates the severity of infection as an immune suppressor and an inhibitor of goblet cell secretion. |
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